LHX4 and CORO1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LHX4	CORO1B
Description		LIM homeobox 4	coronin 1B
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Stress Fiber Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Lamellipodium Cell Leading Edge Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Actin Binding Protein Binding Identical Protein Binding Cadherin Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Actin Filament Organization Cell Migration Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Endothelial Cell Chemotaxis Cellular Response To Platelet-derived Growth Factor Stimulus Wound Healing Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Organization Negative Regulation Of Smooth Muscle Cell Chemotaxis Actin Filament Branching Protein Localization To Cell Leading Edge Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Regulation of expression of SLITs and ROBOs
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Refractive error ( 32231278)	HDL cholesterol levels ( 32203549) Non-response to citalopram or escitalopram and depression ( 27622933) Refractive error ( 32231278)
Interacting Genes		54 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HNF1B HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NFIC NFIX NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 ZBTB2 ZNF354C ZNF76	9 interacting genes: ARPC2 FXR1 KPNA2 LHX4 POLR1C PRKCA SSH1 TERF1 TRIM15
Entrez ID		89884	57175
HPRD ID		03686	16743
Ensembl ID		ENSG00000121454	ENSG00000172725
Uniprot IDs		A0A0S2Z5S4 Q969G2	Q9BR76
PDB IDs		5HOD
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Positive Regulation Of Macromolecule Metabolic Process Regulation Of Viral Life Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Viral Penetration Into Host Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Cellular Component Organization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Protein Kinase C Signaling Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Protein-containing Complex Assembly Positive Regulation Of Shelterin Complex Assembly Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Actin Filament Polymerization Muscle Cell Projection Membrane Cell Leading Edge Regulation Of AMPA Glutamate Receptor Clustering Positive Regulation Of AMPA Glutamate Receptor Clustering Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Intracellular Transport Of Viral Material Mesodermal Cell Fate Determination Medial Motor Column Neuron Differentiation Nucleus Regulation Of Viral Process Positive Regulation Of Gene Expression Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Angiotensin-activated Signaling Pathway RNA Strand Annealing Activity Nuclear Pore Localization Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization To Telomere Fibrillar Center Shelterin Complex Negative Regulation Of Viral Life Cycle Desmosome Assembly
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