MAPRE3 and LAP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAPRE3	LAP3
Description		microtubule associated protein RP/EB family member 3	leucine aminopeptidase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Cytoskeleton Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Midbody Microtubule Plus-end Perinuclear Region Of Cytoplasm Spindle Midzone Neuron To Neuron Synapse Mitotic Spindle Astral Microtubule End Microtubule End	Nucleus Cytoplasm Mitochondrion Trans-Golgi Network Focal Adhesion Extracellular Exosome
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Microtubule Plus-end Binding Protein Serine/threonine Kinase Binding	Aminopeptidase Activity Carboxypeptidase Activity Protein Binding Peptidase Activity Metalloexopeptidase Activity Hydrolase Activity Manganese Ion Binding Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Intracellular Protein Localization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Protein Localization To Microtubule Positive Regulation Of DNA-templated Transcription Behavioral Response To Cocaine Spindle Assembly Cell Division Positive Regulation Of Dendritic Spine Morphogenesis	Proteolysis
Pathways
Drugs			Leucine Phosphonic Acid (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid Zofenoprilat
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate in non-diabetics ( 31451708) Left–right brain asymmetry ( 33723403) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		56 interacting genes: ANKRD1 APC2 AURKA AURKB C20orf202 CCSER1 CHRDL2 CLASP1 CRTAC1 DCTN2 DDIT4L DOK4 EIF4E2 FAM161B FOXD4L1 FOXD4L4 FXR2 GTF2F2 GTSE1 HROB IKZF1 JUN KIF19 KLHDC7B KNSTRN LAP3 LHX4 LMO2 MAPRE2 MARCHF7 MEOX2 MRPL12 PDE4DIP PICK1 POU4F1 PSMA1 PSMB1 PSRC1 RAB1A REL SDCBP SIAH1 SLAIN1 SPDYE2 SPDYE2B SPMIP10 SPMIP2 TLE5 TRAIP TRIM14 TXN2 YAF2 ZC2HC1A ZC2HC1C ZNF526 ZNF547	15 interacting genes: APP BANP CBX3 CBX5 FXR1 LIG4 LINC00632 MAPRE3 OGT PIH1D2 PIK3R3 TAB1 USF1 ZNF76 ZYX
Entrez ID		22924	51056
HPRD ID		16156	07516
Ensembl ID		ENSG00000084764	ENSG00000002549
Uniprot IDs		Q9UPY8	P28838
PDB IDs		1WYO 3CO1 3JAK 3JAL 3JAR 3TQ7 7SJ9
Enriched GO Terms of Interacting Partners?		Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Microtubule Cytoskeleton Organization Spindle Organization Regulation Of Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Microtubule Plus-end Microtubule Cytoskeleton Regulation Of Microtubule-based Process Positive Regulation Of Microtubule Polymerization Cytoskeleton Spindle Microtubule Cytoskeleton Organization Microtubule Microtubule Organizing Center Plasma Membrane Bounded Cell Projection Organization Microtubule Plus-end Binding Cytoplasmic Microtubule Organization Regulation Of Microtubule Polymerization Spindle Midzone Protein Binding Cell Projection Organization Chromosome Passenger Complex Positive Regulation Of Protein Polymerization Microtubule Binding Kinetochore Mitotic Spindle Organization Spindle Assembly Positive Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Depolymerization Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Epithelial Cell Migration Cilium Disassembly Protein Localization To Cytoskeleton Astral Microtubule Organization Beta-catenin Destruction Complex Regulation Of Signal Transduction By P53 Class Mediator Microtubule Cytoskeleton Organization Involved In Mitosis Negative Regulation Of Interferon-beta Production Positive Regulation Of Organelle Organization Regulation Of Organelle Organization Regulation Of Epithelial Cell Migration	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription By Glucose Negative Regulation Of Long-term Synaptic Potentiation Protein Serine/threonine Kinase Binding Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Multicellular Organismal Process Pericentric Heterochromatin Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Macromolecule Biosynthetic Process Establishment Of Integrated Proviral Latency Positive Regulation Of Neurogenesis Chromosome, Telomeric Region Cellular Response To Nutrient Ribonucleoprotein Complex Binding Nuclear Envelope Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Site Of DNA Damage Heterochromatin Regulation Of Glycolytic Process Regulation Of Neuronal Synaptic Plasticity Acetylcholine Receptor Activator Activity Positive Regulation Of Macromolecule Metabolic Process PTB Domain Binding Regulation Of ATP Metabolic Process Regulation Of Macromolecule Biosynthetic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Synapse Organization Negative Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Regulation Of Carbohydrate Catabolic Process Regulation Of Gene Expression Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import
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