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LHX4 and SH2D1A
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid, two hybrid)
LHX4
SH2D1A
Description
LIM homeobox 4
SH2 domain containing 1A
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Cytoplasm
Cytosol
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Zinc Ion Binding
Methyl-CpG Binding
Sequence-specific DNA Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Protein Binding
Protein-macromolecule Adaptor Activity
Biological Process
Placenta Development
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Motor Neuron Axon Guidance
Animal Organ Morphogenesis
Medial Motor Column Neuron Differentiation
Neuron Differentiation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Adaptive Immune Response
Immune System Process
Humoral Immune Response
Cellular Defense Response
Cell-cell Signaling
Natural Killer Cell Activation
Natural Killer Cell Mediated Cytotoxicity
Innate Immune Response
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Immune Response
Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways
Regulation of expression of SLITs and ROBOs
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Refractive error (
32231278
)
Interacting Genes
54 interacting genes:
ADAMTSL4
ARL2
AXIN1
BANP
BOD1L2
CDK3
CENPS-CORT
CHCHD2
CORO1B
DCAF10
DHRS1
DNAJB13
ERO1A
FDX2
GOLGA2
HNF1B
HOXC5
IFT172
IKZF1
INO80B
KLHL38
KRT38
KRT40
LDB2
LONRF1
MAPRE3
MRS2
MYOZ1
NFIC
NFIX
NRF1
ORC6
PARP11
POU1F1
QRICH1
SCAND1
SH2D1A
SNRNP25
SNRPA
SSX1
TCAP
TCF4
TP53BP2
TRAPPC6A
TRMT11
TSEN54
TSTD2
TXNDC5
UBQLN1
USP2
WASHC3
ZBTB2
ZNF354C
ZNF76
32 interacting genes:
AR
ARHGEF6
ARHGEF7
ATF3
CCDC74A
CD84
DOK1
EGFR
ERBB2
ERBB3
ERBB4
FYB1
FYN
GRB2
KIT
LCK
LETMD1
LHX3
LHX4
LY9
MAPK11
MAPK14
MET
NCK1
NGEF
OLIG1
PTK2
SLAMF1
SLAMF6
SLAMF7
TNK2
ZNHIT1
Entrez ID
89884
4068
HPRD ID
03686
02390
Ensembl ID
ENSG00000121454
ENSG00000183918
Uniprot IDs
A0A0S2Z5S4
Q969G2
O60880
PDB IDs
5HOD
1D1Z
1D4T
1D4W
1KA6
1KA7
1M27
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Lymphocyte Activation
Positive Regulation Of Metabolic Process
Cell Activation
Protein Kinase Activity
T Cell Activation
Cell Surface Receptor Signaling Pathway
Cellular Developmental Process
Leukocyte Activation
Kinase Activity
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Biosynthetic Process
Cell Differentiation
Regulation Of Immune System Process
ERBB Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Gene Expression
Regulation Of Programmed Cell Death
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Protein Phosphatase Binding
Regulation Of Multicellular Organismal Process
Intracellular Signaling Cassette
Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Ephrin Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
Signal Transduction
ERBB2 Signaling Pathway
Positive Regulation Of MAPK Cascade
Basal Plasma Membrane
Ephrin Receptor Binding
Regulation Of Metabolic Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Negative Regulation Of Programmed Cell Death
Immune System Process
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
Lamellipodium Assembly
Animal Organ Development
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Regulation Of Apoptotic Process
SH2 Domain Binding
Adaptive Immune Response
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Tagcloud (Intersection)
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