LHX4 and FDX2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		LHX4	FDX2
Description		LIM homeobox 4	ferredoxin 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus	Mitochondrion Mitochondrial Matrix Iron-sulfur Cluster Assembly Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Electron Transfer Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Ubiquinone Biosynthetic Process Iron-sulfur Cluster Assembly Electron Transport Chain [2Fe-2S] Cluster Assembly [4Fe-4S] Cluster Assembly P450-containing Electron Transport Chain
Pathways		Regulation of expression of SLITs and ROBOs	Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes AICSR
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Refractive error ( 32231278)
Interacting Genes		54 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HNF1B HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NFIC NFIX NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 ZBTB2 ZNF354C ZNF76	3 interacting genes: APP LHX4 MEOX2
Entrez ID		89884	112812
HPRD ID		03686	14465
Ensembl ID		ENSG00000121454	ENSG00000267673
Uniprot IDs		A0A0S2Z5S4 Q969G2	Q6P4F2
PDB IDs		5HOD	2Y5C 8RMC 8RMD 8RMF 8RMG
Enriched GO Terms of Interacting Partners?			Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Microtubule-based Transport Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Cell Projection Organization Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Somite Specification Medial Motor Column Neuron Differentiation Outer Dynein Arm Docking Complex Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Axon Choice Point Recognition Determination Of Heart Left/right Asymmetry Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Ciliary Rootlet Anatomical Structure Morphogenesis Developmental Growth Collateral Sprouting Positive Regulation Of RNA Biosynthetic Process Heparan Sulfate Proteoglycan Binding
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