CARD8 and FHL2

Number of citations of the paper that reports this interaction (PMID 12067710)
10

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		CARD8	FHL2
Gene Name		caspase recruitment domain family, member 8	four and a half LIM domains 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm NLRP3 Inflammasome Complex	Nucleus Nucleoplasm Focal Adhesion Actin Cytoskeleton Z Disc M Band
	Molecular Function	Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process NACHT Domain Binding Protein Homodimerization Activity	Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding Androgen Receptor Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interleukin-1 Beta Secretion	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Transcription, DNA-templated Response To Hormone Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG NLRP2 NLRP3	92 interactors: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EIF6 EP300 ESR1 FAM129A FAM154A FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HIF1A ID3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MYBPC1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638
Entrez ID		22900	2274
HPRD ID		16425	04026
Ensembl ID		ENSG00000105483	ENSG00000115641
Uniprot IDs		E5RFV9 I6L9C6 Q9Y2G2	J3KNW4 Q14192 Q2XQU9 Q6I9R8
PDB IDs		4IKM	1X4K 1X4L 2D8Z
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Peptidase Activity Positive Regulation Of Interleukin-1 Production Regulation Of Cellular Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Metabolic Process Regulation Of Interleukin-1 Beta Production Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cytokine Production Zymogen Activation Apoptotic Process Programmed Cell Death Interleukin-1 Beta Production Cell Death Death Regulation Of Cytokine Secretion Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Protein Secretion Positive Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Other Organism Positive Regulation Of Catalytic Activity Protein Processing Response To Biotic Stimulus Innate Immune Response Regulation Of Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Embryo Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Transcription, DNA-templated Formation Of Primary Germ Layer Negative Regulation Of Cellular Metabolic Process Tissue Development Anatomical Structure Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gastrulation Regulation Of Signaling Anatomical Structure Development Response To Organic Substance Organ Morphogenesis Embryonic Morphogenesis
Tagcloud ?		ancient archaea autoproteolysis autoproteolytic deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nlrp1 nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5	acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly
Tagcloud (Difference) ?		ancient archaea autoproteolysis autoproteolytic deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nlrp1 nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5	acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly
Tagcloud (Intersection) ?