CARD8 and CASP1

Number of citations of the paper that reports this interaction (PubMedID 11821383)
0

Data Source:
HPRD (in vivo, in vitro)

		CARD8	CASP1
Description		caspase recruitment domain family member 8	caspase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Canonical Inflammasome Complex NLRP3 Inflammasome Complex CARD8 Inflammasome Complex	Nucleolus Cytoplasm Cytosol Microtubule Plasma Membrane Membrane Protein-containing Complex Canonical Inflammasome Complex IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex Protease Inhibitor Complex
	Molecular Function	Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity NACHT Domain Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity CARD Domain Binding Cysteine-type Endopeptidase Activator Activity Molecular Condensate Scaffold Activity	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity Enzyme Binding Kinase Binding Cytokine Binding Identical Protein Binding CARD Domain Binding
	Biological Process	Activation Of Innate Immune Response Immune System Process Proteolysis Inflammatory Response Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Inflammatory Response Protein Homooligomerization Protein Maturation Defense Response To Virus Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Self Proteolysis Antiviral Innate Immune Response CARD8 Inflammasome Complex Assembly Pyroptotic Cell Death Negative Regulation Of NLRP3 Inflammasome Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Plasma Membrane Repair Pattern Recognition Receptor Signaling Pathway Proteolysis Apoptotic Process Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Protein Secretion Protein Autoprocessing Protein Catabolic Process Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Icosanoid Biosynthetic Process Ceramide Biosynthetic Process Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Maturation Defense Response To Virus Protein Poly-ADP-ribosylation Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Type II Interferon Cytokine Precursor Processing Signaling Receptor Ligand Precursor Processing AIM2 Inflammasome Complex Assembly Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		Formation of apoptosome Regulation of the apoptosome activity	NOD1/2 Signaling Pathway Interleukin-1 processing Pyroptosis TP53 Regulates Transcription of Caspase Activators and Caspases The NLRP3 inflammasome The AIM2 inflammasome The IPAF inflammasome Interleukin-37 signaling Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses
Drugs			Acetylsalicylic acid Minocycline Pralnacasan LAX-101 Emricasan VX-765 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE Z-Val-Ala-Asp fluoromethyl ketone 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
GWAS			Hip circumference adjusted for BMI ( 28552196)
Interacting Genes		9 interacting genes: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG MTDH NLRP2 NLRP3	46 interacting genes: AR ATN1 ATXN3 BCAP31 BCL2L1 BID CARD16 CARD17P CARD8 CASP10 CASP14 CASP8 CAST CDK11B CFTR EGFR FGF2 GSDMD HTT HUWE1 IL18 IL1A IL1B IL33 IL37 LMNA MAPT NEDD4 NFE2L2 NLRC4 NLRP1 NOD1 PAK1 PARP1 PLA2G4A PLA2G4B PRKN PSEN1 PSEN2 PYCARD RIPK2 RNF31 SERPINB9 TFAP2A TIRAP VAC14
Entrez ID		22900	834
HPRD ID		16425	00977
Ensembl ID		ENSG00000105483	ENSG00000137752
Uniprot IDs		Q9Y2G2	A8K249 A8K257 P29466
PDB IDs		4IKM 6K9F 6XKJ 7JKQ 7JN7	1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ 3D6F 3D6H 3D6M 3E4C 3NS7 5FNA 5MMV 5MTK 6BZ9 6F6R 6KN0 6PZP 6VIE 7KEU 8SV1 8WRA
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Cysteine-type Endopeptidase Activity CARD Domain Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Protease Inhibitor Complex Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Negative Regulation Of Interleukin-1 Production Regulation Of Programmed Cell Death Regulation Of DNA-binding Transcription Factor Activity Inflammatory Response Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Interleukin-1 Production Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Regulation Of Intracellular Signal Transduction Response To Lipopolysaccharide Response To External Biotic Stimulus Positive Regulation Of Interleukin-18 Production Regulation Of Canonical NF-kappaB Signal Transduction Response To Molecule Of Bacterial Origin Protein-containing Complex Caspase Binding Regulation Of Interleukin-18 Production Canonical Inflammasome Complex Interleukin-18-mediated Signaling Pathway Regulation Of Cytokine Production Apoptotic Process Cell Death Programmed Cell Death Cellular Response To Lipid Identical Protein Binding Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Protein Binding Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Intracellular Signal Transduction Cysteine-type Endopeptidase Inhibitor Activity Regulation Of Signal Transduction Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Pyroptotic Inflammatory Response Regulation Of Gene Expression Regulation Of Protein Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Osmotic Stress Defense Response	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Programmed Cell Death Cell Death Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Communication Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Regulation Of Interleukin-1 Beta Production Regulation Of Multicellular Organismal Process Regulation Of Defense Response Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Inflammatory Response Regulation Of Interleukin-1 Production Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Cytokine Production Regulation Of Immune Response Positive Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Interleukin-1 Beta Production Apoptotic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Defense Response Positive Regulation Of Interleukin-1 Production Defense Response To Bacterium Identical Protein Binding Negative Regulation Of Apoptotic Signaling Pathway Cytosol Protein-containing Complex Negative Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Innate Immune Response Response To Lipid Regulation Of Immune System Process Canonical Inflammasome Complex Intracellular Signal Transduction
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