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CARD8 and NLRP3
Number of citations of the paper that reports this interaction (PubMedID
15030775
)
0
Data Source:
HPRD
(in vivo)
CARD8
NLRP3
Description
caspase recruitment domain family member 8
NLR family pyrin domain containing 3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Canonical Inflammasome Complex
NLRP3 Inflammasome Complex
CARD8 Inflammasome Complex
Golgi Membrane
Extracellular Region
Nucleus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Golgi Apparatus
Microtubule Organizing Center
Cytosol
Cytoskeleton
Membrane
Interphase Microtubule Organizing Center
Canonical Inflammasome Complex
NLRP3 Inflammasome Complex
Molecular Function
Endopeptidase Activity
Protein Binding
Peptidase Activity
Hydrolase Activity
NACHT Domain Binding
Pattern Recognition Receptor Activity
Protein Homodimerization Activity
CARD Domain Binding
Cysteine-type Endopeptidase Activator Activity
Molecular Condensate Scaffold Activity
Nucleotide Binding
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Protein-macromolecule Adaptor Activity
Signaling Adaptor Activity
Identical Protein Binding
Peptidoglycan Binding
ADP Binding
Sequence-specific DNA Binding
Molecular Adaptor Activity
Phosphatidylinositol-4-phosphate Binding
DNA-binding Transcription Factor Binding
Molecular Sensor Activity
Cysteine-type Endopeptidase Activator Activity
Molecular Condensate Scaffold Activity
Phosphatidylinositol Phosphate Binding
Biological Process
Activation Of Innate Immune Response
Immune System Process
Proteolysis
Inflammatory Response
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Programmed Cell Death
Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-1 Beta Production
Regulation Of Apoptotic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of Inflammatory Response
Protein Homooligomerization
Protein Maturation
Defense Response To Virus
Pyroptotic Inflammatory Response
Intrinsic Apoptotic Signaling Pathway
Self Proteolysis
Antiviral Innate Immune Response
CARD8 Inflammasome Complex Assembly
Pyroptotic Cell Death
Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Pattern Recognition Receptor Signaling Pathway
Immune System Process
Negative Regulation Of Acute Inflammatory Response
Positive Regulation Of Type 2 Immune Response
Regulation Of DNA-templated Transcription
Apoptotic Process
Defense Response
Inflammatory Response
Signal Transduction
Osmosensory Signaling Pathway
Protein Secretion
Detection Of Biotic Stimulus
Response To Virus
Negative Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-18 Production
Positive Regulation Of Interleukin-4 Production
Interleukin-18-mediated Signaling Pathway
NLRP3 Inflammasome Complex Assembly
Innate Immune Response
Positive Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Inflammatory Response
Negative Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Homooligomerization
Protein Maturation
Pyroptotic Inflammatory Response
Interleukin-1-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Virus
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways
Formation of apoptosome
Regulation of the apoptosome activity
Metalloprotease DUBs
The NLRP3 inflammasome
The NLRP3 inflammasome
Purinergic signaling in leishmaniasis infection
Purinergic signaling in leishmaniasis infection
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Cytoprotection by HMOX1
Drugs
Diseases
Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS
Alanine aminotransferase levels (
33547301
)
Aspartate aminotransferase levels (
33547301
)
C-reactive protein levels (
21300955
30388399
)
Fibrinogen (
23969696
20031576
)
Fibrinogen levels (
28107422
26561523
)
Granulocyte count (
27863252
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Mean corpuscular hemoglobin (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of white cells (
27863252
32888494
)
Platelet count (
27863252
32888494
)
Plateletcrit (
32888494
)
Red cell distribution width (
32888494
)
Serum alkaline phosphatase levels (
33547301
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Waist circumference adjusted for body mass index (
25673412
)
White blood cell count (
27863252
32888494
)
Word reading (
23738518
)
Interacting Genes
9 interacting genes:
CARD16
CARD18
CASP1
CASP9
FHL2
IKBKG
MTDH
NLRP2
NLRP3
15 interacting genes:
ANAPC10
ATP1B3
CARD8
CD82
CSNK1A1
CUL1
FAF1
FBXL2
HERC5
IRGM
LAMTOR1
MARCHF7
MARK4
PGM1
PYCARD
Entrez ID
22900
114548
HPRD ID
16425
05915
Ensembl ID
ENSG00000105483
ENSG00000162711
Uniprot IDs
Q9Y2G2
A0A7I2PJH0
A0A7I2PMC6
A0A7I2PRX0
A0A7I2R3P8
Q96P20
PDB IDs
4IKM
6K9F
6XKJ
7JKQ
7JN7
2NAQ
3QF2
6NPY
7ALV
7PZC
7PZD
7VTP
7ZGU
8EJ4
8ERT
8ETR
8RI2
8SWF
8SWK
8SXN
8WSM
8ZEM
9DH3
9GU4
9MGY
9MIE
9MIG
Enriched GO Terms of Interacting Partners
?
Regulation Of Interleukin-1 Beta Production
Regulation Of Interleukin-1 Production
Cysteine-type Endopeptidase Activity
CARD Domain Binding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protease Inhibitor Complex
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Interleukin-1 Beta Production
Regulation Of Apoptotic Process
Negative Regulation Of Interleukin-1 Production
Regulation Of Programmed Cell Death
Regulation Of DNA-binding Transcription Factor Activity
Inflammatory Response
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Interleukin-1 Production
Osmosensory Signaling Pathway
NLRP3 Inflammasome Complex
Regulation Of Intracellular Signal Transduction
Response To Lipopolysaccharide
Response To External Biotic Stimulus
Positive Regulation Of Interleukin-18 Production
Regulation Of Canonical NF-kappaB Signal Transduction
Response To Molecule Of Bacterial Origin
Protein-containing Complex
Caspase Binding
Regulation Of Interleukin-18 Production
Canonical Inflammasome Complex
Interleukin-18-mediated Signaling Pathway
Regulation Of Cytokine Production
Apoptotic Process
Cell Death
Programmed Cell Death
Cellular Response To Lipid
Identical Protein Binding
Interleukin-1-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Negative Regulation Of Protein Binding
Cellular Response To Molecule Of Bacterial Origin
Positive Regulation Of Intracellular Signal Transduction
Cysteine-type Endopeptidase Inhibitor Activity
Regulation Of Signal Transduction
Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pyroptotic Inflammatory Response
Regulation Of Gene Expression
Regulation Of Protein Binding
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Osmotic Stress
Defense Response
Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Regulation Of NLRP3 Inflammasome Complex Assembly
Canonical Inflammasome Complex Assembly
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Autophagy
NLRP3 Inflammasome Complex Assembly
Regulation Of Protein-containing Complex Assembly
Autophagosome Assembly
Autophagosome Organization
Negative Regulation Of Intracellular Signal Transduction
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Negative Regulation Of Protein-containing Complex Assembly
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Protein Catabolic Process
Regulation Of Intracellular Signal Transduction
Vacuole Organization
Macromolecule Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Protein Monoubiquitination
Response To Virus
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Modification Process
TORC1 Signaling
Lysosome Organization
NLRP3 Inflammasome Complex
Regulation Of Defense Response To Virus
Proteolysis
Cysteine-type Endopeptidase Activator Activity
Proteasomal Protein Catabolic Process
Intracellular Signal Transduction
Post-translational Protein Modification
TOR Signaling
Canonical Inflammasome Complex
CARD Domain Binding
Catabolic Process
Regulation Of TORC1 Signaling
Negative Regulation Of Signal Transduction
Defense Response To Virus
Ubiquitin Binding
Negative Regulation Of Autophagy
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Ubiquitination
Regulation Of Protein Metabolic Process
Regulation Of Protein Serine/threonine Kinase Activity
Innate Immune Response
Protein Modification By Small Protein Conjugation
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Tagcloud (Difference)
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Tagcloud (Intersection)
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