CARD8

Description		caspase recruitment domain family member 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Canonical Inflammasome Complex NLRP3 Inflammasome Complex CARD8 Inflammasome Complex
	Molecular Function	Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity NACHT Domain Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity CARD Domain Binding Cysteine-type Endopeptidase Activator Activity Molecular Condensate Scaffold Activity
	Biological Process	Activation Of Innate Immune Response Immune System Process Proteolysis Inflammatory Response Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Inflammatory Response Protein Homooligomerization Protein Maturation Defense Response To Virus Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Self Proteolysis Antiviral Innate Immune Response CARD8 Inflammasome Complex Assembly Pyroptotic Cell Death Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		Formation of apoptosome Regulation of the apoptosome activity
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG MTDH NLRP2 NLRP3
Entrez ID		22900
HPRD ID		16425
Ensembl ID		ENSG00000105483
Uniprot IDs		Q9Y2G2
PDB IDs		4IKM 6K9F 6XKJ 7JKQ 7JN7
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Cysteine-type Endopeptidase Activity CARD Domain Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Protease Inhibitor Complex Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Negative Regulation Of Interleukin-1 Production Regulation Of Programmed Cell Death Regulation Of DNA-binding Transcription Factor Activity Inflammatory Response Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Interleukin-1 Production Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Regulation Of Intracellular Signal Transduction Response To Lipopolysaccharide Response To External Biotic Stimulus Positive Regulation Of Interleukin-18 Production Regulation Of Canonical NF-kappaB Signal Transduction Response To Molecule Of Bacterial Origin Protein-containing Complex Caspase Binding Regulation Of Interleukin-18 Production Canonical Inflammasome Complex Interleukin-18-mediated Signaling Pathway Regulation Of Cytokine Production Apoptotic Process Cell Death Programmed Cell Death Cellular Response To Lipid Identical Protein Binding Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Protein Binding Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Intracellular Signal Transduction Cysteine-type Endopeptidase Inhibitor Activity Regulation Of Signal Transduction Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Pyroptotic Inflammatory Response Regulation Of Gene Expression Regulation Of Protein Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Osmotic Stress Defense Response
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