CARD8 and CASP9

Number of citations of the paper that reports this interaction (PubMedID 11408476)
0

Data Source:
HPRD (in vivo, in vitro)

		CARD8	CASP9
Description		caspase recruitment domain family member 8	caspase 9
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Canonical Inflammasome Complex NLRP3 Inflammasome Complex CARD8 Inflammasome Complex	Nucleus Cytoplasm Mitochondrion Cytosol Caspase Complex Protein-containing Complex Apoptosome
	Molecular Function	Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity NACHT Domain Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity CARD Domain Binding Cysteine-type Endopeptidase Activator Activity Molecular Condensate Scaffold Activity	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Protein Kinase Binding Identical Protein Binding
	Biological Process	Activation Of Innate Immune Response Immune System Process Proteolysis Inflammatory Response Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Inflammatory Response Protein Homooligomerization Protein Maturation Defense Response To Virus Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Self Proteolysis Antiviral Innate Immune Response CARD8 Inflammasome Complex Assembly Pyroptotic Cell Death Negative Regulation Of NLRP3 Inflammasome Complex Assembly	Response To Hypoxia Kidney Development Response To Ischemia Proteolysis Apoptotic Process DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Protein Processing Platelet Formation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Cellular Response To UV Signal Transduction In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Neuron Apoptotic Process Protein Maturation Cellular Response To Dexamethasone Stimulus Response To Indole-3-methanol Leukocyte Apoptotic Process Response To Anesthetic Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Epithelial Cell Apoptotic Process
Pathways		Formation of apoptosome Regulation of the apoptosome activity	Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes NOD1/2 Signaling Pathway AKT phosphorylates targets in the cytosol Caspase activation via Dependence Receptors in the absence of ligand Constitutive Signaling by AKT1 E17K in Cancer Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs			Pamidronic acid
Diseases
GWAS			Alcoholic chronic pancreatitis ( 28754779) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Orofacial cleft x maternal periconceptional multivitamin use interaction (1df) ( 33937227) Orofacial cleft x maternal periconceptional multivitamin use interaction (2df) ( 33937227) Serum metabolite levels ( 33031748) Urate levels ( 31578528) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		9 interacting genes: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG MTDH NLRP2 NLRP3	47 interacting genes: ABL1 AKT1 APAF1 ARNT BCL10 BCL2L1 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 CAPN2 CARD8 CASP10 CASP12 CASP3 CASP7 CASP8 CYCS DCC DIABLO DSP GMEB1 GZMB HECTD3 HIP1 HSD17B4 HSPD1 ILK JUN LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MSTO1 MZB1 NAIP NLRP1 NOD1 PRKCZ RB1 RNF2 SRF VIM XIAP
Entrez ID		22900	842
HPRD ID		16425	03756
Ensembl ID		ENSG00000105483	ENSG00000132906
Uniprot IDs		Q9Y2G2	F8VVS7 P55211
PDB IDs		4IKM 6K9F 6XKJ 7JKQ 7JN7	1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS 4RHW 5JUY 5WVC 5WVE
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Cysteine-type Endopeptidase Activity CARD Domain Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Protease Inhibitor Complex Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Negative Regulation Of Interleukin-1 Production Regulation Of Programmed Cell Death Regulation Of DNA-binding Transcription Factor Activity Inflammatory Response Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Interleukin-1 Production Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Regulation Of Intracellular Signal Transduction Response To Lipopolysaccharide Response To External Biotic Stimulus Positive Regulation Of Interleukin-18 Production Regulation Of Canonical NF-kappaB Signal Transduction Response To Molecule Of Bacterial Origin Protein-containing Complex Caspase Binding Regulation Of Interleukin-18 Production Canonical Inflammasome Complex Interleukin-18-mediated Signaling Pathway Regulation Of Cytokine Production Apoptotic Process Cell Death Programmed Cell Death Cellular Response To Lipid Identical Protein Binding Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Protein Binding Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Intracellular Signal Transduction Cysteine-type Endopeptidase Inhibitor Activity Regulation Of Signal Transduction Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Pyroptotic Inflammatory Response Regulation Of Gene Expression Regulation Of Protein Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Osmotic Stress Defense Response	Programmed Cell Death Cell Death Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Execution Phase Of Apoptosis Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Cytoplasm Regulation Of Defense Response Regulation Of Inflammatory Response Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Defense Response Neuron Apoptotic Process Pyroptotic Inflammatory Response Bergmann Glial Cell Differentiation Regulation Of Golgi Inheritance Negative Regulation Of Apoptotic Process Cytosol Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Cysteine-type Endopeptidase Inhibitor Activity Glial Cell Development Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Regulation Of Protein Modification Process Schwann Cell Development Regulation Of Neuron Apoptotic Process Trachea Formation Response To Lipid Regulation Of Innate Immune Response Regulation Of Metabolic Process Face Development Positive Regulation Of Biosynthetic Process Thymus Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?