RFX6 and FRS3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		RFX6	FRS3
Description		regulatory factor X6	fibroblast growth factor receptor substrate 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Pancreatic Epsilon Cell Differentiation	Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		Regulation of gene expression in beta cells	FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3 RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Chronic obstructive pulmonary disease ( 30804561) Creatine kinase levels ( 29403010) Diastolic blood pressure ( 27841878) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fasting glucose ( 34059833) Height ( 31562340) Inflammatory bowel disease ( 27569725) Lung cancer ( 28604730) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Prostate cancer ( 31562322 20676098 26443449) Serum total protein levels ( 29403010) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)	Menarche (age at onset) ( 25231870)
Interacting Genes		41 interacting genes: AGXT ARNT2 CATSPER1 CCNK CSTF2 CYFIP1 DGCR6 DMRT3 DTX2 DUSP21 ESR2 FHL3 FRS3 HGS KCTD9 KIF1A LGALS4 LMO3 MEMO1 NEDD9 PATZ1 PITX1 PLEKHN1 PRKAA1 PRKAA2 RFX2 RFX3 RIPK3 SAXO4 SNRPB SNRPC SS18L1 STK16 TEKT3 TEKT4 TENT5B TLE5 USP2 VPS37C ZMYND19 ZNF688	112 interacting genes: ACTMAP ADAMTSL4 ANAPC11 ANKRD55 ATP23 BLZF1 BMPR2 C22orf39 CATSPER1 CBY2 CCDC33 CCN3 CDPF1 CFAP68 COL8A1 COPS3 CREB5 CYSRT1 DCDC2B DDX5 DMRT3 DPEP2NB ECM1 ESM1 FGFR1 GATA1 GPRIN2 GRB14 GRB2 HOXA1 HOXD12 ID2 ID3 IKZF3 INCA1 ISY1-RAB43 KARS1 KATNBL1 KCNJ5-AS1 KIAA0408 KPRP KRT31 KRT33B KRT34 KRT35 KRT76 KRTAP1-1 KRTAP10-8 KRTAP11-1 KRTAP3-1 KRTAP3-2 KRTAP6-2 LINGO1 LRRC18 MAPK1 MATK MBD3L1 MIIP NADSYN1 NBPF19 NOTCH2NLA NTRK1 NTRK2 NUMB PCSK5 PDLIM7 PIH1D2 PLB1 PLLP PLSCR1 POF1B PRDM6 PRKCI PTPN11 RFX6 RIMBP3C RND1 SAXO4 SCNM1 SH2B1 SHANK3 SLAIN1 SLC67A1-AS SOCS6 SPATA12 SPRY2 STH STK16 TCF4 TCP10L TGM7 TLE5 TNS1 TRAF4 TRIP6 TSC1 TSGA10IP TSPAN4 UNKL VASP VGLL3 WDR83 WWOX YPEL3 ZMIZ2 ZNF124 ZNF417 ZNF438 ZNF446 ZNF552 ZNF69 ZSCAN30
Entrez ID		222546	10817
HPRD ID		11490	06373
Ensembl ID		ENSG00000185002	ENSG00000137218
Uniprot IDs		Q8HWS3	A0A140VJJ7 O43559
PDB IDs			2KUP 2KUQ 2YS5 2YT2
Enriched GO Terms of Interacting Partners?		Cilium-dependent Cell Motility Axonemal A Tubule Inner Sheath Cilium Movement Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Sperm Motility Flagellated Sperm Motility Sperm Flagellum Cilium Movement Involved In Cell Motility Microtubule-based Movement Protein Localization To Lipid Droplet Protein Binding Nucleus Cilium Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Protein Localization To Vacuole Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Motile Cilium Positive Regulation Of RNA Metabolic Process Phosphatidylethanolamine Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Nucleotide-activated Protein Kinase Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Localization To Lysosome Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cilium Organization Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Fatty Acid Homeostasis Hepatocyte Apoptotic Process U2-type Prespliceosome Positive Regulation Of Biosynthetic Process Organelle Disassembly Cellular Response To Prostaglandin E Stimulus U1 SnRNP Regulation Of Gene Expression Phosphatidylcholine Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Organelle Assembly Positive Regulation Of Glycolytic Process Regulation Of DNA-templated Transcription	Keratin Filament Intermediate Filament Protein Binding Outer Ear Morphogenesis Structural Constituent Of Skin Epidermis Regulation Of Transcription By RNA Polymerase II Regulation Of Ossification Cellular Developmental Process Anatomical Structure Morphogenesis Structural Molecule Activity Intermediate Filament Organization Developmental Process Anatomical Structure Formation Involved In Morphogenesis Response To Growth Factor Neurotrophin Receptor Activity Neurotrophin Binding Negative Regulation Of Chondrocyte Proliferation Myelination Intermediate Filament Cytoskeleton Organization Supramolecular Fiber Organization Intermediate Filament-based Process Cell Differentiation Axon Ensheathment Cellular Response To Growth Factor Stimulus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?