RFX6 and SNRPB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		RFX6	SNRPB
Description		regulatory factor X6	small nuclear ribonucleoprotein polypeptides B and B1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP U7 SnRNP U2-type Spliceosomal Complex U1 SnRNP U2 SnRNP U4 SnRNP U12-type Spliceosomal Complex Telomerase Holoenzyme Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex Methylosome SMN-Sm Protein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Histone Pre-mRNA 3'end Processing Complex Ribonucleoprotein Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	RNA Binding Protein Binding Telomerase RNA Binding SnRNP Binding Histone Pre-mRNA DCP Binding U1 SnRNP Binding U2 SnRNP Binding
	Biological Process	Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Pancreatic Epsilon Cell Differentiation	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing Protein Methylation RNA Splicing 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly
Pathways		Regulation of gene expression in beta cells	SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Chronic obstructive pulmonary disease ( 30804561) Creatine kinase levels ( 29403010) Diastolic blood pressure ( 27841878) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fasting glucose ( 34059833) Height ( 31562340) Inflammatory bowel disease ( 27569725) Lung cancer ( 28604730) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Prostate cancer ( 31562322 20676098 26443449) Serum total protein levels ( 29403010) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		41 interacting genes: AGXT ARNT2 CATSPER1 CCNK CSTF2 CYFIP1 DGCR6 DMRT3 DTX2 DUSP21 ESR2 FHL3 FRS3 HGS KCTD9 KIF1A LGALS4 LMO3 MEMO1 NEDD9 PATZ1 PITX1 PLEKHN1 PRKAA1 PRKAA2 RFX2 RFX3 RIPK3 SAXO4 SNRPB SNRPC SS18L1 STK16 TEKT3 TEKT4 TENT5B TLE5 USP2 VPS37C ZMYND19 ZNF688	91 interacting genes: AKAP9 ASCC2 BAG4 BANP C10orf55 CALCOCO2 CD2BP2 CDKN2A CEP55 CLNS1A COA7 COG6 COIL CREM CTDP1 CYSRT1 DAB1 DDX20 DHX9 DMRTB1 ERG28 EXOSC8 FAM168B FHL3 FNBP4 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GIGYF1 GIGYF2 GOLGA2 HNRNPH1 HOXA1 IL7R INCA1 KRT31 KRT34 KRT40 KRTAP19-1 KRTAP19-6 KRTAP6-1 KRTAP6-2 KRTAP6-3 L3MBTL3 LSM11 LSM8 MAGI2 MBD3L1 OIP5 OOEP PFDN5 PLEKHB2 PNMA1 PRMT5 PRMT7 PRR20A PRR20B PRR20C PRR20D PRR20E PRR22 PSMA3 RBM12 RBPMS RFX6 SERTAD3 SKIC2 SMN1 SMN2 SMNDC1 SNRPD1 SNRPD3 SNUPN SP3 SPAG8 SS18L1 STRAP STXBP2 STXBP3 TFIP11 TOP3B TRAF4 TRIM23 UBQLN2 UBXN11 USP54 WBP4 WDR77 WWP2 ZNF143
Entrez ID		222546	6628
HPRD ID		11490	01655
Ensembl ID		ENSG00000185002	ENSG00000125835
Uniprot IDs		Q8HWS3	P14678 Q66K91
PDB IDs			1D3B 3CW1 3JCR 3PGW 4PJO 4WZJ 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6V4X 6Y53 6Y5Q 7A5P 7ABG 7ABI 7B0Y 7DVQ 7EVO 7QTT 7VPX 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QZS 8R08 8R09 8R0A 8R0B 8R7N 8RC0 8RM5 8RO2 8Y6O 8Y7E 9FMD 9GBW 9GC0 9GCL
Enriched GO Terms of Interacting Partners?		Cilium-dependent Cell Motility Axonemal A Tubule Inner Sheath Cilium Movement Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Sperm Motility Flagellated Sperm Motility Sperm Flagellum Cilium Movement Involved In Cell Motility Microtubule-based Movement Protein Localization To Lipid Droplet Protein Binding Nucleus Cilium Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Protein Localization To Vacuole Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Motile Cilium Positive Regulation Of RNA Metabolic Process Phosphatidylethanolamine Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Nucleotide-activated Protein Kinase Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Localization To Lysosome Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cilium Organization Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Fatty Acid Homeostasis Hepatocyte Apoptotic Process U2-type Prespliceosome Positive Regulation Of Biosynthetic Process Organelle Disassembly Cellular Response To Prostaglandin E Stimulus U1 SnRNP Regulation Of Gene Expression Phosphatidylcholine Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Organelle Assembly Positive Regulation Of Glycolytic Process Regulation Of DNA-templated Transcription	Spliceosomal SnRNP Assembly SMN-Sm Protein Complex SMN Complex Protein-RNA Complex Assembly Gemini Of Cajal Bodies RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome Methylosome Nuclear Body RNA Metabolic Process RNA Binding Nucleus Protein-containing Complex Assembly Protein Binding Protein-containing Complex Organization Nucleic Acid Metabolic Process Cajal Body Nucleoplasm Intermediate Filament PICln-Sm Protein Complex DNA-templated Transcription Termination Precatalytic Spliceosome Spliceosomal Complex Assembly Spliceosomal Complex Cytosol Ribonucleoprotein Complex Binding U4/U6 X U5 Tri-snRNP Complex Small Nuclear Ribonucleoprotein Complex U7 SnRNA Binding Tertiary Granule Protein-arginine Omega-N Symmetric Methyltransferase Activity Nucleobase-containing Compound Metabolic Process Identical Protein Binding U2-type Precatalytic Spliceosome U5 SnRNP Presynaptic Dense Core Vesicle Exocytosis Commitment Complex Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation Spliceosomal Tri-snRNP Complex Neuronal Dense Core Vesicle Exocytosis Methyl-CpG Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing 3'-5' RNA Helicase Activity U7 SnRNP
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