RFX6 and CCNK

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RFX6	CCNK
Gene Name		regulatory factor X, 6	cyclin K
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Cyclin K-CDK12 Complex Cyclin K-CDK13 Complex Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Protein Kinase Binding
	Biological Process	Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Endocrine Pancreas Development Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin Secretion Pancreatic Epsilon Cell Differentiation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity In Utero Embryonic Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Phosphorylation Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Cell Division Negative Regulation Of Cell Cycle Arrest
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 20676098)
Protein-Protein Interactions		25 interactors: AES ARNT2 CATSPER1 CCNK CYFIP1 DGCR6 DTX2 ESR2 FHL3 FRS3 KIF1A LMO3 NEDD9 PITX1 PLEKHN1 PRKAA1 PRKAA2 RFX2 RFX3 RIPK3 SNRPB SNRPC SS18L1 STK16 VPS37C	26 interactors: AES ATXN1 BHLHE40 CCDC85B CDK18 CDK2 CDK9 CEP76 DVL3 EFEMP2 FKBP6 HMG20A KCNRG KRTAP4-12 LZTS2 NDC80 NECAB2 PIN1 POLR2A RBPMS RFX6 RHOXF2 STX11 TSC22D4 UBC USHBP1
Entrez ID		222546	8812
HPRD ID		11490	10352
Ensembl ID		ENSG00000185002
Uniprot IDs		Q8HWS3	O75909
PDB IDs			2I53
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Energy Homeostasis Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Glycolytic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Fatty Acid Homeostasis Transcription From RNA Polymerase II Promoter Epithelial Cell Maturation Nitrogen Compound Metabolic Process Biosynthetic Process Histone-serine Phosphorylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Negative Regulation Of TOR Signaling Cholesterol Biosynthetic Process Positive Regulation Of Autophagy Spliceosomal SnRNP Assembly Histone Phosphorylation Multicellular Organismal Development Sterol Biosynthetic Process Anion Homeostasis Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Cellular Response To Extracellular Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of TOR Signaling Cellular Component Assembly Type B Pancreatic Cell Maturation Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Necroptotic Process Positive Regulation Of Cellular Metabolic Process Wnt Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Branchiomeric Skeletal Muscle Development Negative Regulation Of Glucose Import In Response To Insulin Stimulus	Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Heterocycle Metabolic Process Regulation Of Cell Cycle Arrest Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Metabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Cell Cycle Cellular Nitrogen Compound Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Process Positive Regulation Of Gene Expression Negative Regulation Of Signal Transduction PiRNA Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Mitotic Cell Cycle Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Type I Interferon Production Positive Regulation Of Viral Transcription Regulation Of Protein Ubiquitination
Tagcloud ?		779a agenesis allelic annular atresia awaiting bi biliary cholestatic clues diarrhea duodenal enteroendocrine exome exploratory gallbladder hypoplasia intolerance jaundice jejunal k260t lys260thr malrotation missense monogenic necessitated neonatal pointed splice	affects associate bulk cdk12 cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb
Tagcloud (Difference) ?		779a agenesis allelic annular atresia awaiting bi biliary cholestatic clues diarrhea duodenal enteroendocrine exome exploratory gallbladder hypoplasia intolerance jaundice jejunal k260t lys260thr malrotation missense monogenic necessitated neonatal pointed splice	affects associate bulk cdk12 cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb
Tagcloud (Intersection) ?