RFX6 and CYFIP1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RFX6	CYFIP1
Gene Name		regulatory factor X, 6	cytoplasmic FMR1 interacting protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Ruffle MRNA Cap Binding Complex Focal Adhesion Lamellipodium SCAR Complex Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding	Protein Binding Protein Complex Binding Rac GTPase Binding Actin Filament Binding
	Biological Process	Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Endocrine Pancreas Development Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin Secretion Pancreatic Epsilon Cell Differentiation	Regulation Of Cell Shape Rac Protein Signal Transduction Lamellipodium Assembly Ruffle Organization Axon Extension Cognition Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 20676098)
Protein-Protein Interactions		25 interactors: AES ARNT2 CATSPER1 CCNK CYFIP1 DGCR6 DTX2 ESR2 FHL3 FRS3 KIF1A LMO3 NEDD9 PITX1 PLEKHN1 PRKAA1 PRKAA2 RFX2 RFX3 RIPK3 SNRPB SNRPC SS18L1 STK16 VPS37C	15 interactors: ACTA1 APBB1 EFHC2 EFTUD2 FMR1 FXR2 GAS7 GNB1 MEOX1 PPP1CC PRPF40A RAC1 RFX6 SCTR TCERG1
Entrez ID		222546	23191
HPRD ID		11490	05890
Ensembl ID		ENSG00000185002	ENSG00000068793
Uniprot IDs		Q8HWS3	Q7L576
PDB IDs			3P8C
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Energy Homeostasis Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Glycolytic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Fatty Acid Homeostasis Transcription From RNA Polymerase II Promoter Epithelial Cell Maturation Nitrogen Compound Metabolic Process Biosynthetic Process Histone-serine Phosphorylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Negative Regulation Of TOR Signaling Cholesterol Biosynthetic Process Positive Regulation Of Autophagy Spliceosomal SnRNP Assembly Histone Phosphorylation Multicellular Organismal Development Sterol Biosynthetic Process Anion Homeostasis Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Cellular Response To Extracellular Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of TOR Signaling Cellular Component Assembly Type B Pancreatic Cell Maturation Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Necroptotic Process Positive Regulation Of Cellular Metabolic Process Wnt Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Branchiomeric Skeletal Muscle Development Negative Regulation Of Glucose Import In Response To Insulin Stimulus	Response To Abiotic Stimulus Actin Filament Polymerization Pancreatic Epsilon Cell Differentiation Negative Regulation Of Thymidylate Synthase Biosynthetic Process Pancreatic D Cell Differentiation Actin Filament Organization Response To Light Stimulus System Development Actin Polymerization Or Depolymerization Negative Regulation Of Translation Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Skeletal Muscle Fiber Adaptation Protein Polymerization Engulfment Of Apoptotic Cell Response To Radiation Tissue Development Multicellular Organismal Development Mast Cell Chemotaxis Sclerotome Development Regulation Of Cell Morphogenesis Regulation Of Gene Expression Anatomical Structure Development Response To External Stimulus Energy Reserve Metabolic Process Cell Cycle Arrest Positive Regulation Of DNA Metabolic Process Cytoskeleton Organization Somite Specification
Tagcloud ?		779a agenesis allelic annular atresia awaiting bi biliary cholestatic clues diarrhea duodenal enteroendocrine exome exploratory gallbladder hypoplasia intolerance jaundice jejunal k260t lys260thr malrotation missense monogenic necessitated neonatal pointed splice	4e bdnf boncat cap depends eif4e eif4g encoded find fmrp gtp implicate latter mek mnk1 mnks neurotransmission neurotrophic obscure overlap partner phosphorylates plasticity repressor silac subset synthesis translational whose
Tagcloud (Difference) ?		779a agenesis allelic annular atresia awaiting bi biliary cholestatic clues diarrhea duodenal enteroendocrine exome exploratory gallbladder hypoplasia intolerance jaundice jejunal k260t lys260thr malrotation missense monogenic necessitated neonatal pointed splice	4e bdnf boncat cap depends eif4e eif4g encoded find fmrp gtp implicate latter mek mnk1 mnks neurotransmission neurotrophic obscure overlap partner phosphorylates plasticity repressor silac subset synthesis translational whose
Tagcloud (Intersection) ?