RFX6 and DGCR6

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		RFX6	DGCR6
Gene Name		regulatory factor X, 6	DiGeorge syndrome critical region gene 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Proteinaceous Extracellular Matrix Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding	Molecular_function
	Biological Process	Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Endocrine Pancreas Development Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin Secretion Pancreatic Epsilon Cell Differentiation	Cell Adhesion Organ Morphogenesis
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 20676098)
Protein-Protein Interactions		25 interactors: AES ARNT2 CATSPER1 CCNK CYFIP1 DGCR6 DTX2 ESR2 FHL3 FRS3 KIF1A LMO3 NEDD9 PITX1 PLEKHN1 PRKAA1 PRKAA2 RFX2 RFX3 RIPK3 SNRPB SNRPC SS18L1 STK16 VPS37C	61 interactors: ADAMTSL4 AES AGTRAP APP ARNT2 C1orf94 C3orf62 CBLL1 CCDC33 CCDC36 CCDC67 CTAGE5 CTBP1 DLGAP2 DLX2 DNPEP DOCK8 EFEMP2 EFHC2 ENKD1 FBF1 GOLGA2 GSE1 HGS HOMEZ IKZF3 KIAA1377 KLHL12 LZTS2 MBIP MEIS2 MEOX2 MID2 MIPOL1 NAB2 NECAB2 NOTCH2NL NQO2 NUP54 NUP62 PDLIM7 PRDM14 RABGEF1 REL RFX6 RIMBP3 SPERT SPRY2 SS18L1 TCF12 TCF4 TFIP11 TRAF1 TRAF2 TRIM27 TUBGCP4 VCP ZBED1 ZC4H2 ZNF398 ZNF446
Entrez ID		222546	8214
HPRD ID		11490	03177
Ensembl ID		ENSG00000185002	ENSG00000183628
Uniprot IDs		Q8HWS3	Q14129
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Energy Homeostasis Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Glycolytic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Fatty Acid Homeostasis Transcription From RNA Polymerase II Promoter Epithelial Cell Maturation Nitrogen Compound Metabolic Process Biosynthetic Process Histone-serine Phosphorylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Negative Regulation Of TOR Signaling Cholesterol Biosynthetic Process Positive Regulation Of Autophagy Spliceosomal SnRNP Assembly Histone Phosphorylation Multicellular Organismal Development Sterol Biosynthetic Process Anion Homeostasis Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Cellular Response To Extracellular Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of TOR Signaling Cellular Component Assembly Type B Pancreatic Cell Maturation Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Necroptotic Process Positive Regulation Of Cellular Metabolic Process Wnt Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Branchiomeric Skeletal Muscle Development Negative Regulation Of Glucose Import In Response To Insulin Stimulus	RNA Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Binding Regulation Of ERBB Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Death Developmental Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of ERBB Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Modification By Small Protein Conjugation Nitrogen Compound Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway
Tagcloud ?		779a agenesis allelic annular atresia awaiting bi biliary cholestatic clues diarrhea duodenal enteroendocrine exome exploratory gallbladder hypoplasia intolerance jaundice jejunal k260t lys260thr malrotation missense monogenic necessitated neonatal pointed splice	1rn antidopaminergic daao darpp dgcr2 drd2 drd3 dtnbp1 evolves facets forcefully g72 gabra1 gabra6 gabrp gria1 grin1 grm3 merge mglu2 networking prodh rgs4 slc1a2 slc1a6 underpinned unifying vulnerablility zdhhc8
Tagcloud (Difference) ?		779a agenesis allelic annular atresia awaiting bi biliary cholestatic clues diarrhea duodenal enteroendocrine exome exploratory gallbladder hypoplasia intolerance jaundice jejunal k260t lys260thr malrotation missense monogenic necessitated neonatal pointed splice	1rn antidopaminergic daao darpp dgcr2 drd2 drd3 dtnbp1 evolves facets forcefully g72 gabra1 gabra6 gabrp gria1 grin1 grm3 merge mglu2 networking prodh rgs4 slc1a2 slc1a6 underpinned unifying vulnerablility zdhhc8
Tagcloud (Intersection) ?