RFX6 and FHL3

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RFX6	FHL3
Gene Name		regulatory factor X, 6	four and a half LIM domains 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Stress Fiber Nucleus Focal Adhesion Z Disc
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding	Actin Binding Zinc Ion Binding
	Biological Process	Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Endocrine Pancreas Development Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin Secretion Pancreatic Epsilon Cell Differentiation	Muscle Organ Development Actin Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 20676098)
Protein-Protein Interactions		25 interactors: AES ARNT2 CATSPER1 CCNK CYFIP1 DGCR6 DTX2 ESR2 FHL3 FRS3 KIF1A LMO3 NEDD9 PITX1 PLEKHN1 PRKAA1 PRKAA2 RFX2 RFX3 RIPK3 SNRPB SNRPC SS18L1 STK16 VPS37C	88 interactors: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP C14orf105 C9orf116 CDC25B CDC42EP1 CNNM3 CORO1A CSF1 CTBP2 DCDC2B E2F8 EFCAB12 EPHA10 EPM2AIP1 FAM154A FAM71C FAM90A1 FBXL18 FHL2 FHL5 FOSL2 GATA2 GCM2 HIPK1 HYAL2 ITGA7 KIRREL2 KLF3 KLF8 KRTAP12-1 KRTAP12-2 KTI12 LASP1 LMO2 LNX1 MAPK1 MED15 MPZL1 MRPL27 MYBPC1 MYBPHL MZF1 NPRL3 P4HA2 PAK7 PATL1 PHC2 PHF21A PLEKHF2 PPIG PTPN6 QRICH1 RAD21 RBM42 RFX3 RFX6 RHEBL1 RNMTL1 SAP30BP SLAIN1 SLC25A46 SLC44A3 SMAD2 SMAD3 SMAD4 SNRPG SREBF2 SRF TMX3 TRAF3IP2 TRIM27 TRIP6 TRO TTLL10 TYK2 TYMSOS UBE2I UBE2Q1 WNK1 YPEL3 ZNF417 ZNF512B ZNRD1
Entrez ID		222546	2275
HPRD ID		11490	09101
Ensembl ID		ENSG00000185002	ENSG00000183386
Uniprot IDs		Q8HWS3	Q13643 Q96C98
PDB IDs			1WYH 2CUQ 2EHE
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Energy Homeostasis Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Glycolytic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Fatty Acid Homeostasis Transcription From RNA Polymerase II Promoter Epithelial Cell Maturation Nitrogen Compound Metabolic Process Biosynthetic Process Histone-serine Phosphorylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Negative Regulation Of TOR Signaling Cholesterol Biosynthetic Process Positive Regulation Of Autophagy Spliceosomal SnRNP Assembly Histone Phosphorylation Multicellular Organismal Development Sterol Biosynthetic Process Anion Homeostasis Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Cellular Response To Extracellular Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of TOR Signaling Cellular Component Assembly Type B Pancreatic Cell Maturation Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Necroptotic Process Positive Regulation Of Cellular Metabolic Process Wnt Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Branchiomeric Skeletal Muscle Development Negative Regulation Of Glucose Import In Response To Insulin Stimulus	RNA Metabolic Process Transcription, DNA-templated Gene Expression RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process SMAD Protein Complex Assembly Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cellular Process Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Proliferation Negative Regulation Of RNA Biosynthetic Process Tissue Development Positive Regulation Of Cellular Metabolic Process Cell Death Death Multicellular Organismal Homeostasis Positive Regulation Of Epithelial To Mesenchymal Transition Endoderm Development Negative Regulation Of Cell Growth Embryonic Organ Development Positive Regulation Of Metabolic Process Primary MiRNA Processing Organ Development Apoptotic Process
Tagcloud ?		779a agenesis allelic annular atresia awaiting bi biliary cholestatic clues diarrhea duodenal enteroendocrine exome exploratory gallbladder hypoplasia intolerance jaundice jejunal k260t lys260thr malrotation missense monogenic necessitated neonatal pointed splice	accompanied adhesion anchorage antiproliferative arrest b1 cip1 downregulated g1 g2 half implicated interfering knockdown lim marked marker member mobility p21 progression regulator sirna suppressed thereby transduction unclear waf1
Tagcloud (Difference) ?		779a agenesis allelic annular atresia awaiting bi biliary cholestatic clues diarrhea duodenal enteroendocrine exome exploratory gallbladder hypoplasia intolerance jaundice jejunal k260t lys260thr malrotation missense monogenic necessitated neonatal pointed splice	accompanied adhesion anchorage antiproliferative arrest b1 cip1 downregulated g1 g2 half implicated interfering knockdown lim marked marker member mobility p21 progression regulator sirna suppressed thereby transduction unclear waf1
Tagcloud (Intersection) ?