CBX4 and MBD1

Number of citations of the paper that reports this interaction (PMID 17428788)
10

Data Source:
BioGRID (pull down, affinity chromatography technology)

		CBX4	MBD1
Gene Name		chromobox homolog 4	methyl-CpG binding domain protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck PcG Protein Complex PRC1 Complex	Heterochromatin Nucleus Cytoplasm Nuclear Matrix Nuclear Speck
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding Ligase Activity Enzyme Binding SUMO Binding Methylated Histone Binding Transcription Regulatory Region DNA Binding Phosphoprotein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Chromatin Modification Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated	Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated
Pathways		Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS			Chronic lymphocytic leukemia ( 20062064)
Protein-Protein Interactions		18 interactors: CBS CSNK2B CTBP1 CTBP2 FHL1 HIST3H3 KMT2A LNX2 MBD1 MED9 RB1 RING1 RNF2 SATB1 SKIL SUV39H1 UBE2I ZEB2	24 interactors: APP ATF7IP ATF7IP2 ATXN1L CBX4 CBX5 CHAF1A ECT2 HDAC3 HIPK3 HTT OASL PIAS1 PIAS2 RNF2 SETDB1 SMAD1 SMAD3 SMAD5 SMAD7 SMAD9 SUV39H1 TENM1 ZNF512B
Entrez ID		8535	4152
HPRD ID		04357	01133
Ensembl ID		ENSG00000141582	ENSG00000141644
Uniprot IDs		O00257	A8K654 B4DI41 B4DUR3 K7ELI2 K7EQZ4 K7ESN0 Q9UIS9
PDB IDs		2K28 3I8Z	1D9N 1IG4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Chromatin Modification Histone Modification RNA Metabolic Process Chromosome Organization Cellular Nitrogen Compound Metabolic Process Chromatin Organization Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Viral Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Histone H2A Monoubiquitination Anterior/posterior Pattern Specification Histone H2A Ubiquitination Cellular Metabolic Process Regulation Of Metabolic Process White Fat Cell Differentiation Developmental Process Histone Methylation Histone Monoubiquitination Negative Regulation Of Cell Proliferation Viral Genome Replication Organelle Organization Peptidyl-lysine Trimethylation Protein Methylation Histone Ubiquitination Cell Cycle Cell Differentiation Pattern Specification Process	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Gene Expression Mesonephros Development Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Kidney Epithelium Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus BMP Signaling Pathway Regulation Of Cell Differentiation Response To Growth Factor Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Protein Sumoylation Cellular Protein Modification Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Chromatin Organization Peptidyl-lysine Modification
Tagcloud ?		3p accordingly bodies brachyury cbx7 chemicals ectodermal embryoid endodermal fgf5 foxa2 ideal markers meanwhile mebs mesodermal nanog nestin oct4 pcg perfluorooctane pfos pluripotency polycomb poses sma sox17 sox2 sulfonate	adipose arousal brown entered euthermic expensive ground hdac4 hdacs hibernating hibernation hp1 ictidomys imparted interbout lined lys23 packing repressors reversal rewarms rose shivering squirrels thermogenesis thirteen torpor tridecemlineatus winter
Tagcloud (Difference) ?		3p accordingly bodies brachyury cbx7 chemicals ectodermal embryoid endodermal fgf5 foxa2 ideal markers meanwhile mebs mesodermal nanog nestin oct4 pcg perfluorooctane pfos pluripotency polycomb poses sma sox17 sox2 sulfonate	adipose arousal brown entered euthermic expensive ground hdac4 hdacs hibernating hibernation hp1 ictidomys imparted interbout lined lys23 packing repressors reversal rewarms rose shivering squirrels thermogenesis thirteen torpor tridecemlineatus winter
Tagcloud (Intersection) ?