CBX4 and ARID3C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CBX4	ARID3C
Description		chromobox 4	AT-rich interaction domain 3C
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex	Nucleus Cytoplasm Membrane Raft
	Molecular Function	Transcription Cis-regulatory Region Binding Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding Transferase Activity SUMO Transferase Activity Enzyme Binding SUMO Binding Phosphoprotein Binding SUMO Ligase Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription	Regulation Of Transcription By RNA Polymerase II Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284)
Interacting Genes		28 interacting genes: ARID3C CBS CHD3 CREBBP CTBP1 CTBP2 FHL1 H3-3A H3-4 H3C1 H3C14 KMT2A LNX2 MBD1 MED9 MX1 RB1 RING1 RNF2 SATB1 SKIL SPOP STIP1 SUV39H1 TRIM21 UBE2I ZBED1 ZEB2	3 interacting genes: C14orf119 CBX4 RNF4
Entrez ID		8535	138715
HPRD ID		04357	18550
Ensembl ID		ENSG00000141582	ENSG00000205143
Uniprot IDs		A0A0S2Z5B2 O00257	A6NKF2
PDB IDs		2K28 3I8Z 5EPL
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Nucleus Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II PML Body Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process RING-like Zinc Finger Domain Binding DNA Binding Chromosome Structural Constituent Of Chromatin Protein-DNA Complex Assembly Zinc Ion Binding Nucleosome Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Centromere Complex Assembly Nucleosome Transcription Coregulator Binding Identical Protein Binding Sex Chromatin Nucleosome Organization Positive Regulation Of RNA Metabolic Process Heterochromatin Formation Heterochromatin Transcription Coactivator Activity Unmethylated CpG Binding Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Chromatin	Regulation Of Kinetochore Assembly Regulation Of Centromere Complex Assembly SUMO Polymer Binding Negative Regulation Of Protein Localization To Chromatin Microtubule End Nuclear Body Regulation Of Protein Localization To Chromatin SUMO Binding SUMO Ligase Activity PRC1 Complex SUMO Transferase Activity Protein K6-linked Ubiquitination Post-translational Protein Modification Nucleosome Binding Protein K11-linked Ubiquitination Response To Arsenic-containing Substance Protein Modification By Small Protein Conjugation Regulation Of Spindle Assembly Phosphoprotein Binding PcG Protein Complex Single-stranded RNA Binding
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