CBX4 and ZEB2

Number of citations: 0 (PubMedID 16061479)
Data Source: BioGRID (pull down, affinity chromatography technology, enzymatic study)

		CBX4	ZEB2
Name		chromobox 4	zinc finger E-box binding homeobox 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Plasma Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding Transferase Activity SUMO Transferase Activity Enzyme Binding SUMO Binding Phosphoprotein Binding SUMO Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Phosphatase Regulator Activity Metal Ion Binding R-SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Somitogenesis Neural Tube Closure Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Negative Regulation Of Fibroblast Migration Corpus Callosum Morphogenesis Hippocampus Development Cell Proliferation In Forebrain Corticospinal Tract Morphogenesis Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Myofibroblast Differentiation Stress Fiber Assembly Endothelial Cell Migration Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Melanin Biosynthetic Process Developmental Pigmentation Astrocyte Activation Embryonic Morphogenesis Collateral Sprouting Positive Regulation Of Axonogenesis Mammillary Axonal Complex Development Pyroptotic Inflammatory Response Fibroblast Activation Positive Regulation Of Canonical Wnt Signaling Pathway Response To Oxygen-glucose Deprivation Melanocyte Migration Positive Regulation Of Lens Fiber Cell Differentiation Regulation Of Melanosome Organization Positive Regulation Of Myofibroblast Contraction Regulation Of Myofibroblast Cell Apoptotic Process Regulation Of Blood-brain Barrier Permeability
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription Negative Regulation of CDH1 Gene Transcription Positive Regulation of CDH1 Gene Transcription Formation of the anterior neural plate Formation of the posterior neural plate
Diseases		None	Mowat-Wilson syndrome
GWAS		Brain morphology (MOSTest) ( 32665545 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699 ) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284 )	Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Age-related nuclear cataracts ( 33311586 ) Childhood absence epilepsy ( 30531953 ) Chin dimples ( 27182965 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Corneal astigmatism ( 30306274 ) Coronary artery disease ( 29212778 32469254 26343387 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Diastolic blood pressure ( 30224653 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) General risk tolerance (MTAG) ( 30643258 ) Generalized epilepsy ( 22949513 ) Hand grip strength ( 29691431 ) High myopia ( 31816047 ) Immature fraction of reticulocytes ( 32888494 ) Mean corpuscular hemoglobin ( 29403010 32888494 ) Mean corpuscular hemoglobin concentration ( 29403010 ) Mean corpuscular volume ( 29403010 ) Medication use (diuretics) ( 31015401 ) Myocardial infarction ( 33532862 26343387 ) Obesity-related traits ( 23251661 ) Photic sneeze reflex ( 30899065 27182965 ) Red blood cell count ( 29403010 ) Refractive error ( 32231278 ) Renal cell carcinoma ( 25826619 23184150 ) Retinal detachment or retinal break ( 31816047 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Schizophrenia ( 29483656 23974872 ) Smoking status (ever vs never smokers) ( 30643258 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Triglyceride levels ( 32203549 )
Novel Interactors		None recorded	2 novel interactors: COL16A1 QTMAN
Interacting Genes		28 interacting genes: ARID3C CBS CHD3 CREBBP CTBP1 CTBP2 FHL1 H3-3A H3-4 H3C1 H3C14 KMT2A LNX2 MBD1 MED9 MX1 RB1 RING1 RNF2 SATB1 SKIL SPOP STIP1 SUV39H1 TRIM21 UBE2I ZBED1 ZEB2	16 interacting genes: APP CBX4 COPS6 CTBP1 CTBP2 DDB1 DGKG FBXO45 MTA1 SMAD1 SMAD2 SMAD3 SMAD5 SMAD9 UBE2I USP16
Entrez ID		8535	9839
HPRD ID		04357	05780
Ensembl ID		ENSG00000141582	ENSG00000169554
Uniprot IDs		A0A0S2Z5B2 O00257	O60315
PDB IDs		2K28 3I8Z 5EPL	2DA7
GO Terms Enriched among Interactors		Chromatin Remodeling Nucleus Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II PML Body Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process RING-like Zinc Finger Domain Binding DNA Binding Chromosome Structural Constituent Of Chromatin Protein-DNA Complex Assembly Zinc Ion Binding Nucleosome Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Centromere Complex Assembly Nucleosome Transcription Coregulator Binding Identical Protein Binding Sex Chromatin Nucleosome Organization Positive Regulation Of RNA Metabolic Process Heterochromatin Formation Heterochromatin Transcription Coactivator Activity Unmethylated CpG Binding Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Chromatin	SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway DEAD/H-box RNA Helicase Binding Ureteric Bud Development Mesonephric Epithelium Development Mesonephric Tubule Development Co-SMAD Binding Primary MiRNA Processing Embryonic Pattern Specification Response To Growth Factor Regulation Of Transcription By RNA Polymerase II Kidney Epithelium Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Homomeric SMAD Protein Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Fate Commitment Paraxial Mesoderm Morphogenesis Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex MiRNA Processing Chromatin Binding Regulation Of DNA-templated Transcription Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Biosynthetic Process Osteoblast Differentiation Regulation Of Macromolecule Metabolic Process Anti-Mullerian Hormone Receptor Signaling Pathway Mesoderm Morphogenesis Transcription Coregulator Binding Regulation Of Gene Expression Nucleoplasm Positive Regulation Of Biosynthetic Process Pericardium Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Binding Regulation Of RNA Metabolic Process