CBX4 and KMT2A

Number of citations of the paper that reports this interaction (PubMedID 12829790)
43

Data Source:
BioGRID (pull down, pull down)

		CBX4	KMT2A
Description		chromobox 4	lysine methyltransferase 2A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex MLL1/2 Complex MLL1 Complex
	Molecular Function	Transcription Cis-regulatory Region Binding Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding Transferase Activity SUMO Transferase Activity Enzyme Binding SUMO Binding Phosphoprotein Binding SUMO Ligase Activity	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone H3K4 Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Unmethylated CpG Binding Metal Ion Binding Protein-cysteine Methyltransferase Activity Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription	Immune System Process Chromatin Organization Regulation Of DNA-templated Transcription Apoptotic Process Visual Learning Response To Light Stimulus Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Methylation Circadian Regulation Of Gene Expression Embryonic Hemopoiesis Exploration Behavior Response To Potassium Ion Protein Modification Process Epigenetic Regulation Of Gene Expression T-helper 2 Cell Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Regulation Of Short-term Neuronal Synaptic Plasticity Rhythmic Process Spleen Development Homeostasis Of Number Of Cells Within A Tissue Cognition Membrane Depolarization Definitive Hemopoiesis Protein-containing Complex Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Formation of WDR5-containing histone-modifying complexes Regulation of PD-L1(CD274) transcription Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		28 interacting genes: ARID3C CBS CHD3 CREBBP CTBP1 CTBP2 FHL1 H3-3A H3-4 H3C1 H3C14 KMT2A LNX2 MBD1 MED9 MX1 RB1 RING1 RNF2 SATB1 SKIL SPOP STIP1 SUV39H1 TRIM21 UBE2I ZBED1 ZEB2	33 interacting genes: ASH2L AVP BMI1 CBX4 CREBBP CTNNB1 FASLG H2AC4 H2BC3 H3-3A H3C1 H3C14 HCFC1 HCFC2 INS KAT8 MEN1 MTM1 OXT PAF1 PLXNB1 PPIE PPP1R15A PSIP1 RBBP5 RBM39 RNF2 SBF1 SET SVIL TAF9 TASP1 WDR5
Entrez ID		8535	4297
HPRD ID		04357	01162
Ensembl ID		ENSG00000141582	ENSG00000118058
Uniprot IDs		A0A0S2Z5B2 O00257	A0AA34QVI8 E9PR05 Q03164
PDB IDs		2K28 3I8Z 5EPL	2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2MSR 2MTN 2W5Y 2W5Z 3EG6 3EMH 3LQH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6 4NW3 5F5E 5F6L 5SVH 6EMQ 6KIU 6KIV 6KIX 6KIZ 6PWV 6PWW 6U9K 6U9M 6U9N 6U9R 6W5I 6W5M 6W5N 7MBM 7MBN 7RZD 7RZJ 7S79 7S7D 7S8A 7S8E 7S8F 7U5V 7W67 7W6A 7W6I 7W6J 7ZEY 7ZEZ
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Nucleus Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II PML Body Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process RING-like Zinc Finger Domain Binding DNA Binding Chromosome Structural Constituent Of Chromatin Protein-DNA Complex Assembly Zinc Ion Binding Nucleosome Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Centromere Complex Assembly Nucleosome Transcription Coregulator Binding Identical Protein Binding Sex Chromatin Nucleosome Organization Positive Regulation Of RNA Metabolic Process Heterochromatin Formation Heterochromatin Transcription Coactivator Activity Unmethylated CpG Binding Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Chromatin	MLL1 Complex Chromatin Remodeling MLL1/2 Complex Chromatin Organization Histone Methyltransferase Complex Set1C/COMPASS Complex Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Histone Acetyltransferase Complex NSL Complex Structural Constituent Of Chromatin Negative Regulation Of DNA-templated Transcription Nucleoplasm MLL3/4 Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Neurohypophyseal Hormone Activity DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Transcription Coactivator Activity Nucleosome Assembly Protein-DNA Complex Assembly PRC1 Complex Nucleosome Euchromatin RING-like Zinc Finger Domain Binding Nucleosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Heterodimerization Activity Maternal Aggressive Behavior Positive Regulation Of Macromolecule Biosynthetic Process PcG Protein Complex Positive Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Histone Acetyltransferase Activity Positive Regulation Of Metabolic Process Cell Development Regulation Of Cell Cycle
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