SKA1 and AURKB

Number of citations of the paper that reports this interaction (PMID 22371557)
17

Data Source:
BioGRID (enzymatic study)

		SKA1	AURKB
Gene Name		spindle and kinetochore associated complex subunit 1	aurora kinase B
Image
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Outer Kinetochore Cytosol Spindle Microtubule Microtubule Cytoskeleton	Condensed Chromosome, Centromeric Region Condensed Nuclear Chromosome, Centromeric Region Nucleus Spindle Cytosol Spindle Microtubule Chromocenter Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone
	Molecular Function	Protein Binding Microtubule Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Regulation Of Microtubule Polymerization Or Depolymerization Cell Division	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of B Cell Apoptotic Process Protein Phosphorylation Aging Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore Abscission Histone Modification Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Spindle Checkpoint Negative Regulation Of Protein Binding Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Spindle Stabilization Histone H3-S28 Phosphorylation Protein Autophosphorylation Mitotic Spindle Midzone Assembly Regulation Of Chromosome Segregation
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of mitotic cell cycle Mitotic Anaphase Mitotic Metaphase and Anaphase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: AURKB BLOC1S6 LINC00521 NDC80 SKA2 SPC24 SYCE1	48 interactors: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CENPA CIB1 CYLD DCUN1D1 DES EVI5 FBXL2 FLOT1 GFAP GNB2L1 GSG2 HIST1H3A HIST2H3C HIST3H3 INCENP KIF20A KLHL13 KLHL21 KLHL9 LATS1 LATS2 MAPRE1 MAPRE2 MAPRE3 NCAPH NDC80 NSUN2 NUF2 PPP2R4 PSMA3 RACGAP1 RASA1 RASSF1 SEPT1 SKA1 SKA3 SUMO1 SUMO2 TACC1 TBL3 TGFBR1
Entrez ID		220134	9212
HPRD ID		12689	05397
Ensembl ID		ENSG00000154839	ENSG00000178999
Uniprot IDs		Q96BD8	Q96GD4
PDB IDs		4AJ5	4AF3
Enriched GO Terms of Interacting Partners?		Cell Division Chromosome Segregation Mitotic Nuclear Division Cell Cycle Process Attachment Of Spindle Microtubules To Kinetochore Cell Cycle Organelle Organization Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Spindle Organization Microtubule Anchoring Regulation Of Microtubule Polymerization Or Depolymerization Spindle Organization Regulation Of Microtubule Cytoskeleton Organization Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Microtubule-based Process Regulation Of Microtubule-based Process Histone H3-S28 Phosphorylation Spindle Stabilization Attachment Of Mitotic Spindle Microtubules To Kinetochore Abscission Secretion Of Lysosomal Enzymes Chromosome Organization Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Mitotic Spindle Elongation Endosome To Melanosome Transport Pigment Granule Maturation Synaptic Vesicle Docking Protein Localization To Kinetochore Negative Regulation Of Cytokinesis Cellular Pigment Accumulation Spindle Midzone Assembly Establishment Of Organelle Localization Protein Localization To Chromosome, Centromeric Region Negative Regulation Of B Cell Apoptotic Process Positive Regulation Of Pigment Cell Differentiation Positive Regulation Of Developmental Pigmentation Histone-serine Phosphorylation Organelle Localization Regulation Of B Cell Apoptotic Process Anterograde Synaptic Vesicle Transport Microtubule Cytoskeleton Organization Mitotic Spindle Assembly Melanosome Organization Pigment Granule Organization Synaptonemal Complex Assembly Regulation Of Developmental Pigmentation	Cell Cycle Cell Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Process Mitotic Nuclear Division Organelle Organization Chromosome Segregation Cytokinesis Regulation Of Cell Cycle Regulation Of Microtubule-based Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Sister Chromatid Segregation Mitotic Spindle Organization Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Complex Assembly Positive Regulation Of Microtubule Plus-end Binding Regulation Of Cytoskeleton Organization Cellular Localization Protein Complex Localization Regulation Of Organelle Organization Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Cellular Process Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Regulation Of Protein Localization Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Process Cytoskeleton Organization Positive Regulation Of Protein Modification Process Regulation Of Protein Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of Catalytic Activity Spindle Organization Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		2gammanul amo1 aspm aurkb birc5 bortezomib ccnb1 cd138 cdc2 cdc25c cenpe clonogenic downregulates epc1 hist jjn3 kifs kms myeloma possessing psma5 rpmi shi sp sps top2a ube2d3 ube3c vx	allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Difference) ?		2gammanul amo1 aspm bortezomib ccnb1 cd138 cdc2 cdc25c cenpe clonogenic downregulates epc1 hist jjn3 kifs kms myeloma possessing psma5 rpmi shi sp sps top2a ube2d3 ube3c vx	allele cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Intersection) ?		aurkb birc5