SKA1 and NDC80

Number of citations: 46 (PubMedID 22371557)
Data Source: BioGRID (two hybrid, imaging technique)

		SKA1	NDC80
Name		spindle and kinetochore associated complex subunit 1	NDC80 kinetochore complex component
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Centriolar Satellite Ciliary Basal Body Intercellular Bridge Mitotic Spindle SKA Complex Mitotic Spindle Microtubule	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Membrane Nuclear Speck Ndc80 Complex
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding Microtubule Binding Cyclin Binding Identical Protein Binding Kinetochore Adaptor Activity
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Nuclear Division Spindle Assembly Involved In Female Meiosis Chromosome Segregation Mitotic Metaphase Chromosome Alignment Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Microtubule Polymerization Establishment Of Meiotic Spindle Orientation Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Establishment Of Localization In Cell Establishment Of Organelle Localization Nuclear Chromosome Segregation Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Division Spindle Organization Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling G2/MI Transition Of Meiotic Cell Cycle Attachment Of Spindle Microtubules To Kinetochore Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Stability Chromosome Organization Centrosome Duplication Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Nuclear Chromosome Segregation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
GWAS		Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Large HDL particle concentration ( 29084231 ) Phospholipid levels in large HDL ( 29084231 ) Phospholipid levels in medium HDL ( 29084231 )	Metabolite levels ( 23823483 ) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309 )
Interacting Genes		12 interacting genes: AURKB BLOC1S6 CCDC196 CCDC197 FAM9C NDC80 PSMC5 SKA2 SNAPIN SPC24 SSC5D SYCE1	57 interacting genes: AMOTL2 ATF4 ATP5PO ATP6V1D AURKA AURKB BLOC1S6 CAGE1 CALCOCO1 CCDC136 CCHCR1 CCNH CCNK CEP63 CIP2A CKAP5 EXOC8 GOLGA2 HAUS1 HGS IFT20 INPP1 KIFC3 KLC3 KLHL12 KRT27 KRT6B KRT75 LNX1 MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PPP1R13B PSMC2 RB1 SFR1 SKA1 SKA3 SMC1A SPC25 STX11 TFIP11 THOC7 TOM1L1 TXLNA USHBP1 VPS52 WASHC1 WASHC3 ZNF655 ZWINT
Entrez ID		220134	10403
HPRD ID		12689	06277
Ensembl ID		ENSG00000154839	ENSG00000080986
Uniprot IDs		Q96BD8	A8K031 O14777
PDB IDs		4AJ5 4C9Y 4CA0	2IGP 2VE7 3IZ0 8G0P
GO Terms Enriched among Interactors		Attachment Of Spindle Microtubules To Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Outer Kinetochore Ndc80 Complex Chromosome, Centromeric Region Kinetochore Cell Division Regulation Of Mitotic Sister Chromatid Separation Microvesicle Regulation Of Chromosome Separation Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Spindle Assembly Involved In Female Meiosis Establishment Of Organelle Localization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Meiotic Spindle Assembly BLOC-1 Complex Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division Chromosome Positive Regulation Of Cell Cycle Checkpoint Anterograde Synaptic Vesicle Transport Regulation Of Chromosome Segregation Regulation Of Nuclear Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Cell Cycle Chromosome Segregation Meiotic Spindle Organization Synaptonemal Complex Microtubule-based Process Spindle Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Signaling Organelle Localization Negative Regulation Of Mitotic Metaphase/anaphase Transition Synaptic Vesicle Transport Mitotic Sister Chromatid Segregation Melanosome Organization Pigment Granule Organization Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Segregation Negative Regulation Of Mitotic Cell Cycle Spindle Microtubule Establishment Of Spindle Orientation Anterograde Axonal Transport Vesicle Transport Along Microtubule Negative Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Organization Nuclear Chromosome Segregation Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore	Kinetochore Cell Division Chromosome, Centromeric Region Organelle Organization Regulation Of Mitotic Nuclear Division Regulation Of Nuclear Division Spindle Organization Attachment Of Spindle Microtubules To Kinetochore Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Mitotic Sister Chromatid Separation Chromosome Segregation Centrosome Regulation Of Chromosome Separation Negative Regulation Of Cell Cycle Process Nuclear Chromosome Segregation Microtubule-based Process Negative Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Mitotic Sister Chromatid Segregation Attachment Of Mitotic Spindle Microtubules To Kinetochore Outer Kinetochore Sister Chromatid Segregation Regulation Of Sister Chromatid Segregation Spindle Pole Cytoskeleton Organization Regulation Of Chromosome Segregation Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cytosol Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Nuclear Division Chromosome Spindle Regulation Of Chromosome Organization Positive Regulation Of Mitotic Sister Chromatid Separation Organelle Assembly Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Binding Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Cell Cycle Process Microtubule Chromosome Organization Membraneless Organelle Assembly Cytoskeleton Negative Regulation Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cell Cycle