SKA1 and NDC80

Number of citations of the paper that reports this interaction (PMID 17093495)
44

Data Source:
BioGRID (two hybrid, imaging technique)

		SKA1	NDC80
Gene Name		spindle and kinetochore associated complex subunit 1	NDC80 kinetochore complex component
Image
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Outer Kinetochore Cytosol Spindle Microtubule Microtubule Cytoskeleton	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleus Cytosol Membrane Ndc80 Complex
	Molecular Function	Protein Binding Microtubule Binding	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Regulation Of Microtubule Polymerization Or Depolymerization Cell Division	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: AURKB BLOC1S6 LINC00521 NDC80 SKA2 SPC24 SYCE1	45 interactors: AMOTL2 ATF4 ATP5O AURKA AURKB BLOC1S6 CALCOCO1 CCDC101 CCDC53 CCHCR1 CCNH CCNK CENPH HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MED4 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PSMC2 RB1 RUFY4 SFR1 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 ZWINT
Entrez ID		220134	10403
HPRD ID		12689	06277
Ensembl ID		ENSG00000154839	ENSG00000080986
Uniprot IDs		Q96BD8	A8K031 O14777
PDB IDs		4AJ5	2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Cell Division Chromosome Segregation Mitotic Nuclear Division Cell Cycle Process Attachment Of Spindle Microtubules To Kinetochore Cell Cycle Organelle Organization Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Spindle Organization Microtubule Anchoring Regulation Of Microtubule Polymerization Or Depolymerization Spindle Organization Regulation Of Microtubule Cytoskeleton Organization Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Microtubule-based Process Regulation Of Microtubule-based Process Histone H3-S28 Phosphorylation Spindle Stabilization Attachment Of Mitotic Spindle Microtubules To Kinetochore Abscission Secretion Of Lysosomal Enzymes Chromosome Organization Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Mitotic Spindle Elongation Endosome To Melanosome Transport Pigment Granule Maturation Synaptic Vesicle Docking Protein Localization To Kinetochore Negative Regulation Of Cytokinesis Cellular Pigment Accumulation Spindle Midzone Assembly Establishment Of Organelle Localization Protein Localization To Chromosome, Centromeric Region Negative Regulation Of B Cell Apoptotic Process Positive Regulation Of Pigment Cell Differentiation Positive Regulation Of Developmental Pigmentation Histone-serine Phosphorylation Organelle Localization Regulation Of B Cell Apoptotic Process Anterograde Synaptic Vesicle Transport Microtubule Cytoskeleton Organization Mitotic Spindle Assembly Melanosome Organization Pigment Granule Organization Synaptonemal Complex Assembly Regulation Of Developmental Pigmentation	Mitotic Nuclear Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Division Cell Cycle Chromosome Segregation Cell Cycle Process Negative Regulation Of Cell Cycle Centrosome Separation Organelle Organization Regulation Of Cell Cycle Microtubule-based Process Regulation Of Cell Cycle Process Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Cellular Localization Mitotic Centrosome Separation Microtubule Cytoskeleton Organization Regulation Of Mitotic Nuclear Division Centrosome Localization Spindle Organization Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Mitotic Sister Chromatid Segregation Regulation Of Chromosome Segregation Mitotic Cell Cycle Checkpoint Sister Chromatid Segregation Centrosome Organization Organelle Localization Establishment Of Localization In Cell Microtubule Organizing Center Organization Centrosome Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Intracellular Transport Chromosome Organization Negative Regulation Of Cell Division Spindle Assembly Organelle Assembly Spindle Stabilization Cytoskeleton Organization Protein Localization To Chromosome Establishment Of Organelle Localization Regulation Of Organelle Organization Establishment Of Vesicle Localization Protein Localization To Organelle
Tagcloud ?		2gammanul amo1 aspm aurkb birc5 bortezomib ccnb1 cd138 cdc2 cdc25c cenpe clonogenic downregulates epc1 hist jjn3 kifs kms myeloma possessing psma5 rpmi shi sp sps top2a ube2d3 ube3c vx	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Difference) ?		2gammanul amo1 aspm aurkb birc5 bortezomib ccnb1 cd138 cdc2 cdc25c cenpe clonogenic downregulates epc1 hist jjn3 kifs kms myeloma possessing psma5 rpmi shi sp sps top2a ube2d3 ube3c vx	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Intersection) ?