SKA1 and FAM9C

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SKA1	FAM9C
Description		spindle and kinetochore associated complex subunit 1	family with sequence similarity 9 member C
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Centriolar Satellite Ciliary Basal Body Intercellular Bridge Mitotic Spindle SKA Complex Mitotic Spindle Microtubule	Synaptonemal Complex Nucleus
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Nuclear Division Spindle Assembly Involved In Female Meiosis Chromosome Segregation Mitotic Metaphase Chromosome Alignment Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Microtubule Polymerization Establishment Of Meiotic Spindle Orientation Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Establishment Of Localization In Cell Establishment Of Organelle Localization Nuclear Chromosome Segregation Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling	Spermatid Development Meiotic Cell Cycle
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Itch intensity from mosquito bite adjusted by bite size ( 28199695) Large HDL particle concentration ( 29084231) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231)	Asthma ( 30929738) Asthma (childhood onset) ( 30929738)
Interacting Genes		12 interacting genes: AURKB BLOC1S6 CCDC196 CCDC197 FAM9C NDC80 PSMC5 SKA2 SNAPIN SPC24 SSC5D SYCE1	8 interacting genes: ABI2 BORCS6 CFTR SKA1 SNAPC5 TEX12 TPM3 TRIML2
Entrez ID		220134	171484
HPRD ID		12689	06507
Ensembl ID		ENSG00000154839	ENSG00000187268
Uniprot IDs		Q96BD8	Q8IZT9
PDB IDs		4AJ5 4C9Y 4CA0
Enriched GO Terms of Interacting Partners?		Attachment Of Spindle Microtubules To Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Outer Kinetochore Ndc80 Complex Chromosome, Centromeric Region Kinetochore Cell Division Regulation Of Mitotic Sister Chromatid Separation Microvesicle Regulation Of Chromosome Separation Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Spindle Assembly Involved In Female Meiosis Establishment Of Organelle Localization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Meiotic Spindle Assembly BLOC-1 Complex Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division Chromosome Positive Regulation Of Cell Cycle Checkpoint Anterograde Synaptic Vesicle Transport Regulation Of Chromosome Segregation Regulation Of Nuclear Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Cell Cycle Chromosome Segregation Meiotic Spindle Organization Synaptonemal Complex Microtubule-based Process Spindle Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Signaling Organelle Localization Negative Regulation Of Mitotic Metaphase/anaphase Transition Synaptic Vesicle Transport Mitotic Sister Chromatid Segregation Melanosome Organization Pigment Granule Organization Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Segregation Negative Regulation Of Mitotic Cell Cycle Spindle Microtubule Establishment Of Spindle Orientation Anterograde Axonal Transport Vesicle Transport Along Microtubule Negative Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Organization Nuclear Chromosome Segregation Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore	Bicarbonate Transmembrane Transporter Activity Organelle Localization Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Membrane Hyperpolarization Actin Filament Muscle Thin Filament Tropomyosin Positive Regulation Of Supramolecular Fiber Organization Actin-based Cell Projection Lens Fiber Cell Morphogenesis Zonula Adherens Assembly Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Transcription Initiation At RNA Polymerase III Promoter SnRNA Transcription By RNA Polymerase III Regulation Of Lysosome Size BORC Complex Meiotic DNA Repair Synthesis Central Element Establishment Of Meiotic Spindle Orientation Establishment Of Meiotic Spindle Localization SKA Complex Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling
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