SKA1 and CCDC196

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SKA1	CCDC196
Name		spindle and kinetochore associated complex subunit 1	coiled-coil domain containing 196
Structure			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Centriolar Satellite Ciliary Basal Body Intercellular Bridge Mitotic Spindle SKA Complex Mitotic Spindle Microtubule	None
	Molecular Function	Protein Binding Microtubule Binding	None
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Nuclear Division Spindle Assembly Involved In Female Meiosis Chromosome Segregation Mitotic Metaphase Chromosome Alignment Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Microtubule Polymerization Establishment Of Meiotic Spindle Orientation Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Establishment Of Localization In Cell Establishment Of Organelle Localization Nuclear Chromosome Segregation Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling	None
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	None
GWAS		Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Large HDL particle concentration ( 29084231 ) Phospholipid levels in large HDL ( 29084231 ) Phospholipid levels in medium HDL ( 29084231 )	Cirrhosis (alcohol related) ( 32853455 )
Interacting Genes		12 interacting genes: AURKB BLOC1S6 CCDC196 CCDC197 FAM9C NDC80 PSMC5 SKA2 SNAPIN SPC24 SSC5D SYCE1	32 interacting genes: AMOTL2 ANKRD11 BORCS5 DTNB EIF3F HGS IFT74 KRT20 KRT28 KRT31 KRT34 KRT35 KRT37 KRT39 MEIS2 MEOX2 NXF1 PIK3R3 PKNOX2 RAB3IP SKA1 SNAPC5 STX11 SYCE1L SYCE2 TFIP11 TXLNA TXLNB UBL5 USHBP1 WASF1 ZGPAT
Entrez ID		220134	440184
HPRD ID		12689	14708
Ensembl ID		ENSG00000154839	ENSG00000196553
Uniprot IDs		Q96BD8	A0A1B0GTZ2 A0A1B0GV15 A0A286YEX8
PDB IDs		4AJ5 4C9Y 4CA0	Not available
GO Terms Enriched among Interactors		Attachment Of Spindle Microtubules To Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Outer Kinetochore Ndc80 Complex Chromosome, Centromeric Region Kinetochore Cell Division Regulation Of Mitotic Sister Chromatid Separation Microvesicle Regulation Of Chromosome Separation Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Spindle Assembly Involved In Female Meiosis Establishment Of Organelle Localization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Meiotic Spindle Assembly BLOC-1 Complex Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division Chromosome Positive Regulation Of Cell Cycle Checkpoint Anterograde Synaptic Vesicle Transport Regulation Of Chromosome Segregation Regulation Of Nuclear Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Cell Cycle Chromosome Segregation Meiotic Spindle Organization Synaptonemal Complex Microtubule-based Process Spindle Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Signaling Organelle Localization Negative Regulation Of Mitotic Metaphase/anaphase Transition Synaptic Vesicle Transport Mitotic Sister Chromatid Segregation Melanosome Organization Pigment Granule Organization Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Segregation Negative Regulation Of Mitotic Cell Cycle Spindle Microtubule Establishment Of Spindle Orientation Anterograde Axonal Transport Vesicle Transport Along Microtubule Negative Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Organization Nuclear Chromosome Segregation Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore	Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Organelle Organization Morphogenesis Of An Epithelium Supramolecular Fiber Organization Epithelial Cell Differentiation Tissue Morphogenesis Cytoskeleton Organization Anatomical Structure Morphogenesis Cytoskeleton Synaptonemal Complex Assembly Synaptonemal Complex Organization