SKA1 and SPC24

Number of citations of the paper that reports this interaction (PMID 22371557)
17

Data Source:
BioGRID (two hybrid)

		SKA1	SPC24
Gene Name		spindle and kinetochore associated complex subunit 1	SPC24, NDC80 kinetochore complex component
Image
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Outer Kinetochore Cytosol Spindle Microtubule Microtubule Cytoskeleton	Condensed Chromosome Kinetochore Nucleus Nucleolus Cytosol Ndc80 Complex
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Regulation Of Microtubule Polymerization Or Depolymerization Cell Division	Mitotic Cell Cycle Mitotic Nuclear Division Cell Division
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			HDL cholesterol ( 23505323)
Protein-Protein Interactions		7 interactors: AURKB BLOC1S6 LINC00521 NDC80 SKA2 SPC24 SYCE1	5 interactors: APP PSEN2 SKA1 SKA2 SKA3
Entrez ID		220134	147841
HPRD ID		12689	15464
Ensembl ID		ENSG00000154839
Uniprot IDs		Q96BD8	B4DZZ7 Q8NBT2
PDB IDs		4AJ5	2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Cell Division Chromosome Segregation Mitotic Nuclear Division Cell Cycle Process Attachment Of Spindle Microtubules To Kinetochore Cell Cycle Organelle Organization Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Spindle Organization Microtubule Anchoring Regulation Of Microtubule Polymerization Or Depolymerization Spindle Organization Regulation Of Microtubule Cytoskeleton Organization Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Microtubule-based Process Regulation Of Microtubule-based Process Histone H3-S28 Phosphorylation Spindle Stabilization Attachment Of Mitotic Spindle Microtubules To Kinetochore Abscission Secretion Of Lysosomal Enzymes Chromosome Organization Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Mitotic Spindle Elongation Endosome To Melanosome Transport Pigment Granule Maturation Synaptic Vesicle Docking Protein Localization To Kinetochore Negative Regulation Of Cytokinesis Cellular Pigment Accumulation Spindle Midzone Assembly Establishment Of Organelle Localization Protein Localization To Chromosome, Centromeric Region Negative Regulation Of B Cell Apoptotic Process Positive Regulation Of Pigment Cell Differentiation Positive Regulation Of Developmental Pigmentation Histone-serine Phosphorylation Organelle Localization Regulation Of B Cell Apoptotic Process Anterograde Synaptic Vesicle Transport Microtubule Cytoskeleton Organization Mitotic Spindle Assembly Melanosome Organization Pigment Granule Organization Synaptonemal Complex Assembly Regulation Of Developmental Pigmentation	Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Chromosome Segregation Regulation Of Epidermal Growth Factor-activated Receptor Activity Endoplasmic Reticulum Calcium Ion Homeostasis Mitotic Nuclear Division Cell Division Regulation Of Protein Tyrosine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of ERBB Signaling Pathway Regulation Of Cellular Component Organization Mitotic Cell Cycle Process Regulation Of Receptor Activity Mitotic Cell Cycle Notch Signaling Pathway Regulation Of Protein Binding Synaptic Growth At Neuromuscular Junction Regulation Of Organelle Organization Collateral Sprouting In Absence Of Injury Regulation Of Peptidyl-tyrosine Phosphorylation Cell Cycle Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Learning Or Memory Axon Choice Point Recognition Cognition Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cell Cycle Neuron Remodeling Amyloid Precursor Protein Catabolic Process Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Forebrain Development Cellular Ion Homeostasis Single-organism Behavior Membrane Protein Intracellular Domain Proteolysis Metal Ion Homeostasis Cellular Copper Ion Homeostasis Membrane Protein Ectodomain Proteolysis Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cellular Ketone Metabolic Process
Tagcloud ?		2gammanul amo1 aspm aurkb birc5 bortezomib ccnb1 cd138 cdc2 cdc25c cenpe clonogenic downregulates epc1 hist jjn3 kifs kms myeloma possessing psma5 rpmi shi sp sps top2a ube2d3 ube3c vx
Tagcloud (Difference) ?		2gammanul amo1 aspm aurkb birc5 bortezomib ccnb1 cd138 cdc2 cdc25c cenpe clonogenic downregulates epc1 hist jjn3 kifs kms myeloma possessing psma5 rpmi shi sp sps top2a ube2d3 ube3c vx
Tagcloud (Intersection) ?