SKA1

Name	spindle and kinetochore associated complex subunit 1
Structure
Interactors	12 interactors: AURKB BLOC1S6 CCDC196 CCDC197 FAM9C NDC80 PSMC5 SKA2 SNAPIN SPC24 SSC5D SYCE1
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Centriolar Satellite Ciliary Basal Body Intercellular Bridge Mitotic Spindle SKA Complex Mitotic Spindle Microtubule
	Molecular Function	Protein Binding Microtubule Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Nuclear Division Spindle Assembly Involved In Female Meiosis Chromosome Segregation Mitotic Metaphase Chromosome Alignment Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Microtubule Polymerization Establishment Of Meiotic Spindle Orientation Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Establishment Of Localization In Cell Establishment Of Organelle Localization Nuclear Chromosome Segregation Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling
Pathways	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
GWAS	Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Large HDL particle concentration ( 29084231 ) Phospholipid levels in large HDL ( 29084231 ) Phospholipid levels in medium HDL ( 29084231 )
Entrez ID	220134
HPRD ID	12689
Ensembl ID	ENSG00000154839
Uniprot IDs	Q96BD8
PDB IDs	4AJ5 4C9Y 4CA0
GO Terms Enriched among Interactors ?	Attachment Of Spindle Microtubules To Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Outer Kinetochore Ndc80 Complex Chromosome, Centromeric Region Kinetochore Cell Division Regulation Of Mitotic Sister Chromatid Separation Microvesicle Regulation Of Chromosome Separation Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Spindle Assembly Involved In Female Meiosis Establishment Of Organelle Localization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Meiotic Spindle Assembly BLOC-1 Complex Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division Chromosome Positive Regulation Of Cell Cycle Checkpoint Anterograde Synaptic Vesicle Transport Regulation Of Chromosome Segregation Regulation Of Nuclear Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Cell Cycle Chromosome Segregation Meiotic Spindle Organization Synaptonemal Complex Microtubule-based Process Spindle Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Signaling Organelle Localization Negative Regulation Of Mitotic Metaphase/anaphase Transition Synaptic Vesicle Transport Mitotic Sister Chromatid Segregation Melanosome Organization Pigment Granule Organization Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Segregation Negative Regulation Of Mitotic Cell Cycle Spindle Microtubule Establishment Of Spindle Orientation Anterograde Axonal Transport Vesicle Transport Along Microtubule Negative Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Organization Nuclear Chromosome Segregation Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore