F2RL1 and COPS5

Number of citations of the paper that reports this interaction (PMID 16410250)
10

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		F2RL1	COPS5
Gene Name		coagulation factor II (thrombin) receptor-like 1	COP9 signalosome subunit 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Pseudopodium	Nucleus Nucleoplasm Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	G-protein Alpha-subunit Binding Receptor Activity G-protein Coupled Receptor Activity Receptor Binding Protein Binding Thrombin Receptor Activity G-protein Beta-subunit Binding	Transcription Coactivator Activity Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding
	Biological Process	T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Glomerular Filtration Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Rho Protein Signal Transduction Chemokine (C-C Motif) Ligand 2 Secretion Neutrophil Activation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Eosinophil Degranulation Innate Immune Response Positive Regulation Of Vasodilation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Interleukin-1 Beta Secretion Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Positive Chemotaxis Defense Response To Virus Positive Regulation Of Phagocytosis, Engulfment Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Thrombin Receptor Signaling Pathway Leukocyte Proliferation Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Interleukin-10 Secretion Interferon-gamma Secretion Chemokine Secretion Negative Regulation Of Chemokine Secretion Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion	Protein Deneddylation Transcription From RNA Polymerase II Promoter Translation Translational Initiation Proteolysis Cullin Deneddylation Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Regulation Of Cell Cycle Exosomal Secretion
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CAPN1 CAPN2 CBL COPS5 CTSG ELANE F2 GPRASP1 PLG PRTN3 ST14	90 interactors: APCS ARFGAP1 ATRN BCL2L14 BCL3 C12orf10 C6orf203 CACNA1C CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4A CUL5 DDB1 DDO ERN1 ESR1 F2RL1 GFER GFI1B GPS1 HAND2 HIF1A HNF4A HNF4G HTR6 HUS1 ITGB2 JUN JUND LOC284014 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 NR5A2 OPRM1 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG
Entrez ID		2150	10987
HPRD ID		02960	06888
Ensembl ID		ENSG00000164251	ENSG00000121022
Uniprot IDs		P55085	Q92905
PDB IDs			4F7O
Enriched GO Terms of Interacting Partners?		Proteolysis Extracellular Matrix Disassembly Protein Metabolic Process Killing By Host Of Symbiont Cells Negative Regulation Of Fibrinolysis Receptor Catabolic Process Regulation Of Fibrinolysis Extracellular Matrix Organization Extracellular Structure Organization Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Catabolic Process Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Fibrinolysis Positive Regulation Of Blood Coagulation Interaction With Symbiont Leukocyte Mediated Cytotoxicity Leukocyte Migration Positive Regulation Of Coagulation Response To Fungus Positive Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Negative Regulation Of Coagulation Positive Regulation Of Cell Proliferation Collagen Catabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Wound Healing Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Acute Inflammatory Response Receptor Metabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Multicellular Organismal Metabolic Process Blood Coagulation Hemostasis Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus G-protein Coupled Receptor Catabolic Process Regulation Of Blood Coagulation Mononuclear Cell Migration Regulation Of Wound Healing Immune System Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Exosomal Secretion Positive Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Response To Stress	Positive Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Stimulus Response To Stimulus Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Gene Expression Signaling Cullin Deneddylation Positive Regulation Of Cellular Biosynthetic Process Death Anatomical Structure Development Cellular Response To Organic Substance Response To Abiotic Stimulus Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Cellular Process Response To Lipid Developmental Process Cell Death Multicellular Organismal Development Protein Deneddylation Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Response To Organic Cyclic Compound Apoptotic Process Programmed Cell Death System Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To Radiation Organ Development Defense Response Cell Proliferation Regulation Of Phosphorus Metabolic Process
Tagcloud ?		adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rhog rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2	abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite
Tagcloud (Difference) ?		adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rhog rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2	abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite
Tagcloud (Intersection) ?