F2RL1 and SDHD

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		F2RL1	SDHD
Description		F2R like trypsin receptor 1	succinate dehydrogenase complex subunit D
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GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Plasma Membrane Membrane Pseudopodium	Mitochondrion Mitochondrial Envelope Mitochondrial Inner Membrane Membrane Respiratory Chain Complex II (succinate Dehydrogenase)
	Molecular Function	Proteinase-activated Receptor Activity G-protein Alpha-subunit Binding Protease Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding Signaling Receptor Activity	Protein Binding Succinate Dehydrogenase (quinone) Activity Electron Transfer Activity Heme Binding Metal Ion Binding Ubiquinone Binding
	Biological Process	T Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Glomerular Filtration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Chemokine Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Rho Protein Signal Transduction Neutrophil Activation Vasodilation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Eosinophil Degranulation Positive Regulation Of GTPase Activity Innate Immune Response Cell-cell Junction Maintenance Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Positive Chemotaxis Defense Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phagocytosis, Engulfment Establishment Of Endothelial Barrier Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Leukocyte Proliferation Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Renin Secretion Into Blood Stream Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Tricarboxylic Acid Cycle Mitochondrial Electron Transport, Succinate To Ubiquinone Proton Motive Force-driven Mitochondrial ATP Synthesis Regulation Of Catecholamine Secretion Cellular Response To Hypoxia
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle
Drugs			Hexachlorophene 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1
Diseases			Carcinoid
GWAS		Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171)	Brain morphology (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		76 interacting genes: ABCC8 ABHD14A ADCY2 ARL6IP1 ATP2A2 ATP2B1 ATP2C1 BSG CANX CAPN1 CAPN2 CAPNS1 CBL CD63 CD81 CLPTM1 CNN3 COPS5 CRLS1 CTNNA1 CTSG DNMT3L ELANE ERGIC3 F2 GJB6 GJC2 GPRASP1 HERPUD1 HLA-E HMOX2 HSPA1B ICAM2 KDELR1 KLC1 LMNA MORN4 NAT14 NBPF15 OSTC P4HTM PHLDA1 PIGU PLG PPM1J PRNP PRRT2 PRTN3 PSMC3 PTDSS2 QSER1 R3HDM1 RGR RTN1 RTN4 SCN1B SDHD SLC12A5 SLC18B1 SLC1A4 SLC31A2 SLC32A1 SLC35A1 SLC39A13 SLC43A2 SLC75A1 ST14 SYNGR2 TMBIM1 TMED1 TMEM161A TMEM62 TMX2 WFS1 YIPF1 YIPF6	5 interacting genes: F2RL1 GPR35 MTNR1B RHBDD2 SLC13A1
Entrez ID		2150	6392
HPRD ID		02960	04069
Ensembl ID		ENSG00000164251	ENSG00000204370
Uniprot IDs		P55085	A0A0S2Z4H7 A0A0S2Z4J3 O14521
PDB IDs		5NDD 5NDZ 5NJ6	8GS8
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Cellular Homeostasis Intracellular Chemical Homeostasis Endoplasmic Reticulum Calpain Complex Endoplasmic Reticulum Tubular Network Formation Endoplasmic Reticulum Membrane Intracellular Monoatomic Cation Homeostasis Synaptic Vesicle Membrane Intracellular Monoatomic Ion Homeostasis Regulation Of Transport Inorganic Ion Homeostasis Endoplasmic Reticulum Tubular Network Membrane Organization Transmembrane Transport P-type Calcium Transporter Activity Calcium-dependent Cysteine-type Endopeptidase Activity Neutrophil-mediated Killing Of Bacterium Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Inorganic Ion Transmembrane Transport Biological Process Involved In Interaction With Symbiont Serine-type Peptidase Activity Intracellular Calcium Ion Homeostasis Inorganic Cation Transmembrane Transport Positive Regulation Of Transport Monoatomic Cation Transmembrane Transport Regulation Of Metal Ion Transport Cytoplasmic Vesicle Endoplasmic Reticulum Membrane Organization Regulation Of Postsynapse Assembly Monoatomic Ion Transmembrane Transport Chemical Homeostasis Dendrite Calcium Ion Homeostasis Serine-type Endopeptidase Activity Acidic Amino Acid Transport Endoplasmic Reticulum Tubular Network Organization Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Negative Regulation Of Apoptotic Signaling Pathway Neutrophil Mediated Immunity Regulation Of Monoatomic Ion Transport Golgi Apparatus Endoplasmic Reticulum Calcium Ion Homeostasis Neutrophil-mediated Killing Of Gram-negative Bacterium Negative Regulation Of Amyloid-beta Formation Monoatomic Cation Transport Positive Regulation Of Blood Coagulation Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Protein Localization	Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion G Protein-coupled Receptor Activity Negative Regulation Of Protein Secretion Negative Regulation Of Hormone Secretion Negative Regulation Of Transport Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Proteinase-activated Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Negative Regulation Of Secretion By Cell Positive Regulation Of Glomerular Filtration G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Transport Regulation Of Renin Secretion Into Blood Stream Regulation Of Tube Size Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Establishment Of Protein Localization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Regulation Of Insulin Secretion Negative Regulation Of Secretion Positive Regulation Of Killing Of Cells Of Another Organism Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Peptide Hormone Secretion Mature Conventional Dendritic Cell Differentiation Thrombin-activated Receptor Activity Regulation Of Neuronal Action Potential Negative Regulation Of Protein Localization Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Hormone Secretion Regulation Of Protein Secretion Vascular Process In Circulatory System C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Secondary Active Sulfate Transmembrane Transporter Activity Signal Recognition Particle Binding Regulation Of Glomerular Filtration Thrombin-activated Receptor Signaling Pathway
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