F2RL1 and CTSG

Number of citations of the paper that reports this interaction (PMID 10978167)
15

Data Source:
HPRD (in vitro)

		F2RL1	CTSG
Gene Name		coagulation factor II (thrombin) receptor-like 1	cathepsin G
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Pseudopodium	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Surface Secretory Granule Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	G-protein Alpha-subunit Binding Receptor Activity G-protein Coupled Receptor Activity Receptor Binding Protein Binding Thrombin Receptor Activity G-protein Beta-subunit Binding	Serine-type Endopeptidase Activity Heparin Binding Peptidase Activity
	Biological Process	T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Glomerular Filtration Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Rho Protein Signal Transduction Chemokine (C-C Motif) Ligand 2 Secretion Neutrophil Activation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Eosinophil Degranulation Innate Immune Response Positive Regulation Of Vasodilation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Interleukin-1 Beta Secretion Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Positive Chemotaxis Defense Response To Virus Positive Regulation Of Phagocytosis, Engulfment Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Thrombin Receptor Signaling Pathway Leukocyte Proliferation Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Interleukin-10 Secretion Interferon-gamma Secretion Chemokine Secretion Negative Regulation Of Chemokine Secretion Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion	Angiotensin Maturation Proteolysis Immune Response Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Response To Lipopolysaccharide Negative Regulation Of Growth Of Symbiont In Host Cellular Protein Metabolic Process Positive Regulation Of Immune Response Defense Response To Fungus Neutrophil Mediated Killing Of Gram-positive Bacterium
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Peptide hormone metabolism Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Degradation of the extracellular matrix
Drugs			Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CAPN1 CAPN2 CBL COPS5 CTSG ELANE F2 GPRASP1 PLG PRTN3 ST14	28 interactors: AGT C3 CAMP CASP7 CXCL12 CXCR4 ERBB2IP F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NL PARP1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1
Entrez ID		2150	1511
HPRD ID		02960	00289
Ensembl ID		ENSG00000164251	ENSG00000100448
Uniprot IDs		P55085	P08311
PDB IDs			1AU8 1CGH 1KYN 1T32
Enriched GO Terms of Interacting Partners?		Proteolysis Extracellular Matrix Disassembly Protein Metabolic Process Killing By Host Of Symbiont Cells Negative Regulation Of Fibrinolysis Receptor Catabolic Process Regulation Of Fibrinolysis Extracellular Matrix Organization Extracellular Structure Organization Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Catabolic Process Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Fibrinolysis Positive Regulation Of Blood Coagulation Interaction With Symbiont Leukocyte Mediated Cytotoxicity Leukocyte Migration Positive Regulation Of Coagulation Response To Fungus Positive Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Negative Regulation Of Coagulation Positive Regulation Of Cell Proliferation Collagen Catabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Wound Healing Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Acute Inflammatory Response Receptor Metabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Multicellular Organismal Metabolic Process Blood Coagulation Hemostasis Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus G-protein Coupled Receptor Catabolic Process Regulation Of Blood Coagulation Mononuclear Cell Migration Regulation Of Wound Healing Immune System Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Exosomal Secretion Positive Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Response To Stress	Cell Activation Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Inflammatory Response Blood Coagulation Hemostasis Wound Healing Response To Wounding Negative Regulation Of Endopeptidase Activity Response To Stress Negative Regulation Of Peptidase Activity Regulation Of Body Fluid Levels Platelet Activation Regulation Of Proteolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Thrombin Receptor Signaling Pathway Regulation Of Protein Processing Response To Stimulus Regulation Of Cellular Protein Metabolic Process Defense Response Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Migration Platelet Degranulation Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Transport Regulation Of Catalytic Activity Regulation Of Blood Coagulation Negative Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Regulation Of Wound Healing Regulation Of Chemotaxis Response To Cytokine Response To Other Organism Positive Regulation Of Leukocyte Chemotaxis Blood Circulation Response To Biotic Stimulus Secretion By Cell Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Secretion Positive Regulation Of Cell Migration Cellular Chemical Homeostasis Positive Regulation Of Cell Motility
Tagcloud ?		adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rhog rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2	aaa aaas aneurysms ang angiotensin aortas aortic cacl2 catg cathepsin converting elastin elastinolytic gelatin immunofluorescent indices indirectly ldlr lesion littermate metalloproteinases mm2 participates periaortic producing protease smcs untested zymogram
Tagcloud (Difference) ?		adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rhog rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2	aaa aaas aneurysms ang angiotensin aortas aortic cacl2 catg cathepsin converting elastin elastinolytic gelatin immunofluorescent indices indirectly ldlr lesion littermate metalloproteinases mm2 participates periaortic producing protease smcs untested zymogram
Tagcloud (Intersection) ?