F2RL1 and ST14

Number of citations of the paper that reports this interaction (PMID 10831593)
75

Data Source:
HPRD (in vitro)

		F2RL1	ST14
Gene Name		coagulation factor II (thrombin) receptor-like 1	suppression of tumorigenicity 14 (colon carcinoma)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Pseudopodium	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Alpha-subunit Binding Receptor Activity G-protein Coupled Receptor Activity Receptor Binding Protein Binding Thrombin Receptor Activity G-protein Beta-subunit Binding	Serine-type Endopeptidase Activity Serine-type Peptidase Activity
	Biological Process	T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Glomerular Filtration Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Rho Protein Signal Transduction Chemokine (C-C Motif) Ligand 2 Secretion Neutrophil Activation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Eosinophil Degranulation Innate Immune Response Positive Regulation Of Vasodilation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Interleukin-1 Beta Secretion Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Positive Chemotaxis Defense Response To Virus Positive Regulation Of Phagocytosis, Engulfment Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Thrombin Receptor Signaling Pathway Leukocyte Proliferation Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Interleukin-10 Secretion Interferon-gamma Secretion Chemokine Secretion Negative Regulation Of Chemokine Secretion Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion	Proteolysis Keratinocyte Differentiation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Urokinase Benzamidine
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CAPN1 CAPN2 CBL COPS5 CTSG ELANE F2 GPRASP1 PLG PRTN3 ST14	7 interactors: CDCP1 F2RL1 HGF PDGFC PLAU RGS16 SPINT1
Entrez ID		2150	6768
HPRD ID		02960	06005
Ensembl ID		ENSG00000164251	ENSG00000149418
Uniprot IDs		P55085	Q9Y5Y6
PDB IDs			1EAW 1EAX 2FMV 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO
Enriched GO Terms of Interacting Partners?		Proteolysis Extracellular Matrix Disassembly Protein Metabolic Process Killing By Host Of Symbiont Cells Negative Regulation Of Fibrinolysis Receptor Catabolic Process Regulation Of Fibrinolysis Extracellular Matrix Organization Extracellular Structure Organization Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Catabolic Process Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Fibrinolysis Positive Regulation Of Blood Coagulation Interaction With Symbiont Leukocyte Mediated Cytotoxicity Leukocyte Migration Positive Regulation Of Coagulation Response To Fungus Positive Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Negative Regulation Of Coagulation Positive Regulation Of Cell Proliferation Collagen Catabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Wound Healing Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Acute Inflammatory Response Receptor Metabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Multicellular Organismal Metabolic Process Blood Coagulation Hemostasis Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus G-protein Coupled Receptor Catabolic Process Regulation Of Blood Coagulation Mononuclear Cell Migration Regulation Of Wound Healing Immune System Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Exosomal Secretion Positive Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Response To Stress	Blood Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Hemostasis Regulation Of Phosphatidylinositol 3-kinase Signaling Interleukin-10 Secretion Negative Regulation Of Chemokine Secretion Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Regulation Of Cell Motility Regulation Of Wound Healing Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Chemokine Secretion Chemokine (C-C Motif) Ligand 2 Secretion Positive Regulation Of Eosinophil Degranulation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Cell Migration Positive Regulation Of Phosphorylation Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Renin Secretion Into Blood Stream Myoblast Proliferation Interleukin-1 Beta Secretion Cell Motility Regulation Of Peptidyl-tyrosine Phosphorylation Interleukin-10 Production Regulation Of Catalytic Activity Positive Regulation Of Glomerular Filtration Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Cytokine Secretion Involved In Immune Response Mature Conventional Dendritic Cell Differentiation Interleukin-1 Secretion Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Interleukin-6 Secretion Negative Regulation Of Signal Transduction Negative Regulation Of Endopeptidase Activity Interferon-gamma Secretion Negative Regulation Of Peptidase Activity Activation Of Protein Kinase Activity Positive Regulation Of Cell Projection Organization Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling
Tagcloud ?		adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rhog rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2	acetylation box coding compartment downregulates emt enables epcam epithelial esrp1 expected h358 h3k27 h3k9 h4 hdac hgf immunocytochemistry immunoprecipitation mesenchymal metastasis migratory note protease rab25 serine splicing stroma zeb1
Tagcloud (Difference) ?		adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rhog rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2	acetylation box coding compartment downregulates emt enables epcam epithelial esrp1 expected h358 h3k27 h3k9 h4 hdac hgf immunocytochemistry immunoprecipitation mesenchymal metastasis migratory note protease rab25 serine splicing stroma zeb1
Tagcloud (Intersection) ?