ADAR and LINC00624

Number of citations of the paper that reports this interaction (PubMedID 36252997)
50

Data Source:
BioGRID (unspecified method)

		ADAR	LINC00624
Description		adenosine deaminase RNA specific	long intergenic non-protein coding RNA 624
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Nuclear Lumen Supraspliceosomal Complex
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity Adenosine Deaminase Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Osteoblast Differentiation Hematopoietic Progenitor Cell Differentiation Immune System Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Adenosine To Inosine Editing RNA Processing MRNA Processing Protein Import Into Nucleus Protein Export From Nucleus Apoptotic Process Response To Virus Base Conversion Or Substitution Editing Erythrocyte Differentiation Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing MiRNA Processing Response To Interferon-alpha Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Definitive Hemopoiesis Negative Regulation Of Type I Interferon-mediated Signaling Pathway Hematopoietic Stem Cell Homeostasis RISC Complex Assembly Hepatocyte Apoptotic Process Cellular Response To Virus Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Hepatocyte Apoptotic Process
Pathways		C6 deamination of adenosine Formation of editosomes by ADAR proteins Interferon alpha/beta signaling PKR-mediated signaling
Drugs
Diseases		Dyschromatosis symmetrica hereditaria
GWAS		Apolipoprotein A1 levels ( 32203549) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Interleukin-6 levels ( 33517400) Lung cancer ( 28604730) Prostate cancer ( 23535732) Squamous cell lung carcinoma ( 28604730)	Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) End-stage kidney disease ( 31178898) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		10 interacting genes: CEBPA ERG HDLBP LINC00624 PTEN SMURF2 TGM2 UBE2I USP7 XPO1	38 interacting genes: ACTA1 ACTC1 ADAR ALB CCT2 CCT4 CPNE3 DDX42 DDX5 EIF2AK2 FUBP3 G6PD H2BC18 HDAC6 HNRNPL HNRNPM HNRNPU HRNR ILF3 MCCC1 MCCC2 NONO PARP1 PTBP1 PTBP2 PTBP3 SERBP1 SFPQ SND1 SRRT STAU1 STAU2 TRIM28 TUBA1B TUBA1C UBAP2L YBX3 ZNF354C
Entrez ID		103	100289211
HPRD ID		07528
Ensembl ID		ENSG00000160710	ENSG00000278811
Uniprot IDs		A0AAQ5BGH8 P55265
PDB IDs		1QBJ 1QGP 1XMK 2ACJ 2GXB 2L54 2MDR 3F21 3F22 3F23 3IRQ 3IRR 5ZU1 5ZUO 5ZUP 7C0I 7ZJ1 7ZLQ 8GBC 8GBD
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Membrane Assembly Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity SUMO Conjugating Enzyme Activity Regulation Of RNA Metabolic Process Nucleus Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Response To Vitamin B2 C/EBP Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Protein Deamination Cellular Response To Triglyceride Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Cellular Response To Serotonin RING-like Zinc Finger Domain Binding Symbiont-mediated Disruption Of Host Cell PML Body Sterol Metabolic Process Nucleoplasm Cholesterol Metabolic Process Negative Regulation Of Metabolic Process White Fat Cell Proliferation Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells SUMO Ligase Complex HLH Domain Binding Response To Triglyceride	RNA Binding RNA Localization Nucleic Acid Binding Double-stranded RNA Binding MRNA Processing MRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Viral Genome Replication Negative Regulation Of Metabolic Process Dendritic Transport Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression RNA Splicing Regulation Of Viral Life Cycle RNA Processing Cytoskeleton-dependent Intracellular Transport Alternative MRNA Splicing, Via Spliceosome Regulation Of Viral Process RNA Metabolic Process Cell Body Nucleus Axo-dendritic Transport Paraspeckles Regulation Of Macromolecule Biosynthetic Process Intracellular MRNA Localization Extracellular Exosome Regulation Of RNA Splicing Methylcrotonoyl-CoA Carboxylase Complex Methylcrotonoyl-CoA Carboxylase Activity Regulation Of Telomere Maintenance Via Telomere Lengthening Pre-mRNA Binding Cytoplasm Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Dendritic Transport Of Messenger Ribonucleoprotein Complex Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Response To Chemical Stress Negative Regulation Of RNA Splicing Negative Regulation Of RNA Metabolic Process Regulatory NcRNA-mediated Gene Silencing Transport Along Microtubule Binding Of Sperm To Zona Pellucida Mesenchyme Migration ScaRNA Localization To Cajal Body
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