ADAR and HDLBP

Number of citations of the paper that reports this interaction (PMID 15723802)
27

Data Source:
HPRD (in vitro)

		ADAR	HDLBP
Gene Name		adenosine deaminase, RNA-specific	high density lipoprotein binding protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Supraspliceosomal Complex	Nucleus Cytoplasm Plasma Membrane High-density Lipoprotein Particle
	Molecular Function	DNA Binding Double-stranded RNA Adenosine Deaminase Activity Protein Binding Poly(A) RNA Binding Metal Ion Binding	Protein Binding Lipid Binding Poly(A) RNA Binding
	Biological Process	Osteoblast Differentiation In Utero Embryonic Development Hematopoietic Progenitor Cell Differentiation Somatic Diversification Of Immune Receptors Via Somatic Mutation Adenosine To Inosine Editing MRNA Processing Protein Import Into Nucleus Protein Export From Nucleus Response To Virus Gene Expression Base Conversion Or Substitution Editing MRNA Modification Cytokine-mediated Signaling Pathway Erythrocyte Differentiation Pre-miRNA Processing MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Response To Interferon-alpha Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Definitive Hemopoiesis Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Hematopoietic Stem Cell Homeostasis Negative Regulation Of RNA Interference	Lipid Transport Cholesterol Metabolic Process
Pathways		Formation of editosomes by ADAR proteins Interferon Signaling Cytokine Signaling in Immune system mRNA Editing: A to I Conversion C6 deamination of adenosine Interferon alpha/beta signaling mRNA Editing
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Prostate cancer ( 23535732)
Protein-Protein Interactions		5 interactors: ERG HDLBP TGM2 UBE2I XPO1	7 interactors: ADAR CSNK2A1 DHX9 FAM46A SMAD4 SOS1 XPOT
Entrez ID		103	3069
HPRD ID		07528	00813
Ensembl ID		ENSG00000160710	ENSG00000115677
Uniprot IDs		P55265	Q00341
PDB IDs		1QBJ 1QGP 1XMK 2ACJ 2GXB 2L54 3F21 3F22 3F23 3IRQ 3IRR	1VIG 1VIH 2CTE 2CTF 2CTJ 2CTK 2CTL 2CTM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Potassium Ion Export Positive Regulation Of SUMO Transferase Activity Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Regulation Of Heart Rate By Hormone Ribosomal Small Subunit Export From Nucleus Peptidyl-amino Acid Modification Peptidyl-lysine Modification Salivary Gland Cavitation Ribosomal Large Subunit Export From Nucleus Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Ribosomal Subunit Export From Nucleus Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Heart Rate By Chemical Signal Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Peptidyl-histidine Phosphorylation Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Negative Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Mitochondrial Calcium Ion Homeostasis Phosphorelay Signal Transduction System Positive Regulation Of Potassium Ion Transmembrane Transport Metal Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter Ventricular Cardiac Muscle Cell Action Potential Response To Drug Regulation Of Membrane Repolarization Negative Regulation Of Potassium Ion Transport Regulation Of Heart Rate By Cardiac Conduction Viral Process Ion Homeostasis Regulation Of Protein Export From Nucleus Protein Sumoylation Intracellular Transport Of Virus Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Branching Involved In Salivary Gland Morphogenesis Apoptotic Cell Clearance Protein Export From Nucleus Endoplasmic Reticulum Calcium Ion Homeostasis Membrane Depolarization During Action Potential Regulation Of Centrosome Duplication Cardiac Muscle Cell Action Potential Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Centrosome Cycle	Axon Guidance Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Protein Catabolic Process Chemotaxis Nuclear Export Regulation Of Cell Death Negative Regulation Of RNA Interference TRNA Export From Nucleus Nephrogenic Mesenchyme Morphogenesis Neuron Projection Morphogenesis Osteoblast Differentiation Adenosine To Inosine Editing Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Cell Morphogenesis Involved In Differentiation Cell Differentiation Response To External Stimulus Innate Immune Response Neuron Projection Development Cell Projection Morphogenesis CRD-mediated MRNA Stabilization Cell Part Morphogenesis Negative Regulation Of Protein Metabolic Process Endocardial Cell Differentiation Hematopoietic Stem Cell Homeostasis Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Base Conversion Or Substitution Editing Neuron Development Negative Regulation Of Cell Death Negative Regulation Of Type I Interferon-mediated Signaling Pathway Formation Of Anatomical Boundary Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Endothelial Cell Activation Nucleocytoplasmic Transport Nuclear Transport Cell Morphogenesis MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Regulation Of Transforming Growth Factor Beta2 Production Ossification Positive Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Valve Formation Sebaceous Gland Development Neuron Differentiation Rhythmic Process Cell Projection Organization Somite Rostral/caudal Axis Specification Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Tagcloud ?		adar2 adars adenosines azan azanebularine biophysical deaminase deaminases deaminate deaminated deeper deoxy dsrbd dsrbds duplex edited editing emsa footprinting hadar2 hydrolytically mechanistically misregulation modular nt nucleoside positioning ribonuclease v1	accurately adam12 cancers candidate centb1 centg1 dip2c exome gli1 grin2d hedgehog ikbkb infrequent involvement kb kpna5 mutation nfkb1 notch notch1 otof pik3ca point prevalence recurring sequencing somatic strengthen substantial
Tagcloud (Difference) ?		adar2 adars adenosines azan azanebularine biophysical deaminase deaminases deaminate deaminated deeper deoxy dsrbd dsrbds duplex edited editing emsa footprinting hadar2 hydrolytically mechanistically misregulation modular nt nucleoside positioning ribonuclease v1	accurately adam12 cancers candidate centb1 centg1 dip2c exome gli1 grin2d hedgehog ikbkb infrequent involvement kb kpna5 mutation nfkb1 notch notch1 otof pik3ca point prevalence recurring sequencing somatic strengthen substantial
Tagcloud (Intersection) ?