ADAR

Name	adenosine deaminase RNA specific
Structure
Interactors	10 interactors: CEBPA ERG HDLBP LINC00624 PTEN SMURF2 TGM2 UBE2I USP7 XPO1
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Nuclear Lumen Supraspliceosomal Complex
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity Adenosine Deaminase Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Osteoblast Differentiation Hematopoietic Progenitor Cell Differentiation Immune System Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Adenosine To Inosine Editing RNA Processing MRNA Processing Protein Import Into Nucleus Protein Export From Nucleus Apoptotic Process Response To Virus Base Conversion Or Substitution Editing Erythrocyte Differentiation Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing MiRNA Processing Response To Interferon-alpha Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Definitive Hemopoiesis Negative Regulation Of Type I Interferon-mediated Signaling Pathway Hematopoietic Stem Cell Homeostasis RISC Complex Assembly Hepatocyte Apoptotic Process Cellular Response To Virus Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Hepatocyte Apoptotic Process
Pathways	C6 deamination of adenosine Formation of editosomes by ADAR proteins Interferon alpha/beta signaling PKR-mediated signaling
Diseases	Dyschromatosis symmetrica hereditaria
GWAS	Apolipoprotein A1 levels ( 32203549 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Interleukin-6 levels ( 33517400 ) Lung cancer ( 28604730 ) Prostate cancer ( 23535732 ) Squamous cell lung carcinoma ( 28604730 )
Entrez ID	103
HPRD ID	07528
Ensembl ID	ENSG00000160710
Uniprot IDs	A0AAQ5BGH8 P55265
PDB IDs	1QBJ 1QGP 1XMK 2ACJ 2GXB 2L54 2MDR 3F21 3F22 3F23 3IRQ 3IRR 5ZU1 5ZUO 5ZUP 7C0I 7ZJ1 7ZLQ 8GBC 8GBD
GO Terms Enriched among Interactors ?	Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Membrane Assembly Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity SUMO Conjugating Enzyme Activity Regulation Of RNA Metabolic Process Nucleus Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Response To Vitamin B2 C/EBP Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Protein Deamination Cellular Response To Triglyceride Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Cellular Response To Serotonin RING-like Zinc Finger Domain Binding Symbiont-mediated Disruption Of Host Cell PML Body Sterol Metabolic Process Nucleoplasm Cholesterol Metabolic Process Negative Regulation Of Metabolic Process White Fat Cell Proliferation Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells SUMO Ligase Complex HLH Domain Binding Response To Triglyceride