ADAR and XPO1

Number of citations of the paper that reports this interaction (PMID 11604520)
35

Data Source:
BioGRID (unspecified method)
HPRD (in vitro, in vivo)

		ADAR	XPO1
Gene Name		adenosine deaminase, RNA-specific	exportin 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Supraspliceosomal Complex	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Ribonucleoprotein Complex Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Double-stranded RNA Adenosine Deaminase Activity Protein Binding Poly(A) RNA Binding Metal Ion Binding	RNA Binding Transporter Activity Nucleocytoplasmic Transporter Activity Protein Binding Ran GTPase Binding Protein Transporter Activity Protein Domain Specific Binding
	Biological Process	Osteoblast Differentiation In Utero Embryonic Development Hematopoietic Progenitor Cell Differentiation Somatic Diversification Of Immune Receptors Via Somatic Mutation Adenosine To Inosine Editing MRNA Processing Protein Import Into Nucleus Protein Export From Nucleus Response To Virus Gene Expression Base Conversion Or Substitution Editing MRNA Modification Cytokine-mediated Signaling Pathway Erythrocyte Differentiation Pre-miRNA Processing MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Response To Interferon-alpha Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Definitive Hemopoiesis Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Hematopoietic Stem Cell Homeostasis Negative Regulation Of RNA Interference	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Protein Export From Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Centrosome Duplication Viral Process Viral Life Cycle Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization To Nucleus Regulation Of Protein Catabolic Process Response To Drug Regulation Of Protein Export From Nucleus MRNA Transport Intracellular Transport Of Virus
Pathways		Formation of editosomes by ADAR proteins Interferon Signaling Cytokine Signaling in Immune system mRNA Editing: A to I Conversion C6 deamination of adenosine Interferon alpha/beta signaling mRNA Editing	Loss of Function of TGFBR2 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt TGF-beta receptor signaling activates SMADs Influenza Life Cycle Export of Viral Ribonucleoproteins from Nucleus RNF mutants show enhanced WNT signaling and proliferation Regulation of mRNA stability by proteins that bind AU-rich elements TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Host Interactions of HIV factors Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Influenza Infection Late Phase of HIV Life Cycle Resolution of Sister Chromatid Cohesion Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Mitotic Prometaphase Separation of Sister Chromatids HIV Infection Rev-mediated nuclear export of HIV RNA G2/M Transition Mitotic Anaphase TGFBR1 LBD Mutants in Cancer HuR stabilizes mRNA deactivation of the beta-catenin transactivating complex M Phase HIV Life Cycle Rev-mediated nuclear export of HIV RNA Cyclin A/B1 associated events during G2/M transition XAV939 inhibits tankyrase, stabilizing AXIN NEP/NS2 Interacts with the Cellular Export Machinery Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Interactions of Rev with host cellular proteins Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Signaling by WNT in cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		5 interactors: ERG HDLBP TGM2 UBE2I XPO1	72 interactors: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 CCND1 CDC25A CDCA4 CDKN1B CHEK1 CHORDC1 CIITA CRK DDX3X DR1 E2F4 E2F5 EIF5A ERF FBXO7 FOXO4 HDAC3 HNF4A HSPA9 IRF5 KIF17 MAPK6 NF2 NMD3 NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 ORC1 PHAX PHB PKIA PXN RAN RANBP1 RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SNUPN SOX2 STAT1 STRADA TERF2IP TERT TOP2A TOP2B TP73
Entrez ID		103	7514
HPRD ID		07528	03975
Ensembl ID		ENSG00000160710	ENSG00000082898
Uniprot IDs		P55265	B3KWD0 O14980
PDB IDs		1QBJ 1QGP 1XMK 2ACJ 2GXB 2L54 3F21 3F22 3F23 3IRQ 3IRR	1W9C 2L1L 3GB8 4BSM 4BSN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Potassium Ion Export Positive Regulation Of SUMO Transferase Activity Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Regulation Of Heart Rate By Hormone Ribosomal Small Subunit Export From Nucleus Peptidyl-amino Acid Modification Peptidyl-lysine Modification Salivary Gland Cavitation Ribosomal Large Subunit Export From Nucleus Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Ribosomal Subunit Export From Nucleus Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Heart Rate By Chemical Signal Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Peptidyl-histidine Phosphorylation Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Negative Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Mitochondrial Calcium Ion Homeostasis Phosphorelay Signal Transduction System Positive Regulation Of Potassium Ion Transmembrane Transport Metal Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter Ventricular Cardiac Muscle Cell Action Potential Response To Drug Regulation Of Membrane Repolarization Negative Regulation Of Potassium Ion Transport Regulation Of Heart Rate By Cardiac Conduction Viral Process Ion Homeostasis Regulation Of Protein Export From Nucleus Protein Sumoylation Intracellular Transport Of Virus Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Branching Involved In Salivary Gland Morphogenesis Apoptotic Cell Clearance Protein Export From Nucleus Endoplasmic Reticulum Calcium Ion Homeostasis Membrane Depolarization During Action Potential Regulation Of Centrosome Duplication Cardiac Muscle Cell Action Potential Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Centrosome Cycle	Cell Cycle Cell Cycle Process Nucleocytoplasmic Transport Mitotic Cell Cycle Nuclear Transport Mitotic Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Organelle Organization Cytoplasmic Transport Nuclear Export Positive Regulation Of Gene Expression Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Gene Expression Negative Regulation Of Kinase Activity Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Export From Nucleus Intracellular Transport Response To Organic Substance Negative Regulation Of Phosphorylation RNA Transport RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Localization Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Protein Kinase Activity Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity RNA Metabolic Process Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Process Regulation Of Kinase Activity Regulation Of Cell Cycle Process Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Proliferation Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity
Tagcloud ?		adar2 adars adenosines azan azanebularine biophysical deaminase deaminases deaminate deaminated deeper deoxy dsrbd dsrbds duplex edited editing emsa footprinting hadar2 hydrolytically mechanistically misregulation modular nt nucleoside positioning ribonuclease v1	accounting atm bioinformatics birc3 concordance confirmation conservative cutoff discordant eventually haloplex hiseq ighv ighv3 klhl6 lymphocytic myd88 next notch1 pot1 precision recurrently repeating reproducible sanger sequencing sf3b1 stand unmutated
Tagcloud (Difference) ?		adar2 adars adenosines azan azanebularine biophysical deaminase deaminases deaminate deaminated deeper deoxy dsrbd dsrbds duplex edited editing emsa footprinting hadar2 hydrolytically mechanistically misregulation modular nt nucleoside positioning ribonuclease v1	accounting atm bioinformatics birc3 concordance confirmation conservative cutoff discordant eventually haloplex hiseq ighv ighv3 klhl6 lymphocytic myd88 next notch1 pot1 precision recurrently repeating reproducible sanger sequencing sf3b1 stand unmutated
Tagcloud (Intersection) ?