XAGE2 and FOXP4

Number of citations: 20 (PubMedID 21516116)
Data Source: BioGRID (two hybrid)

		XAGE2	FOXP4
Name		X antigen family member 2	forkhead box P4
Structure		No pdb structure
GO Annotations	Cellular Component	None	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	None	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
GWAS		No GWAS studies recorded	Chronotype ( 30696823 ) EGFR mutation-positive lung adenocarcinoma ( 27501781 ) Fasting insulin ( 34059833 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Metabolite levels ( 23823483 ) Non-small cell lung cancer ( 31326317 ) Prostate cancer ( 20676098 31562322 )
Interacting Genes		7 interacting genes: EHMT2 EPS8 FOXP4 GMCL1 GMCL2 POT1 TERF2IP	10 interacting genes: FOXP1 FOXP2 NR2F1 NR2F2 SATB1 SATB2 SOX5 XAGE2 YY1 ZMYM2
Entrez ID		9502	116113
HPRD ID		02332	10600
Ensembl ID		ENSG00000155622	ENSG00000137166
Uniprot IDs		Q96GT9	B7ZBM3 Q8IVH2
PDB IDs		Not available	6XAT
GO Terms Enriched among Interactors		Nuclear Telomere Cap Complex Shelterin Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase Germ Cell Development RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Chromosome Organization Histone H3K56 Methyltransferase Activity Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Chromosome Organization DNA Biosynthetic Process Regulation Of Organelle Organization Regulation Of DNA Metabolic Process Positive Regulation Of Telomeric Loop Disassembly Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Negative Regulation Of DNA Recombination At Telomere Phenotypic Switching 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomere Organization Nuclear Matrix Negative Regulation Of DNA Metabolic Process Adult Behavior Regulation Of Double-strand Break Repair Telomeric D-loop Binding Telomere Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Peptidyl-lysine Dimethylation Chromosome Single-stranded Telomeric DNA Binding Chromosome, Telomeric Region Histone H3K27 Methyltransferase Activity Actin Polymerization-dependent Cell Motility Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere Histone H3K9me2 Methyltransferase Activity DEAD/H-box RNA Helicase Binding NMDA Selective Glutamate Receptor Complex Behavioral Response To Ethanol	DNA-binding Transcription Factor Activity Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Negative Regulation Of Metabolic Process Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Nuclear Matrix Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Cardiac Muscle Tissue Growth Negative Regulation Of Organ Growth Nuclear Lumen Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Macromolecule Metabolic Process Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Striated Muscle Cell Differentiation Cellular Developmental Process Zinc Ion Binding Nuclear Receptor Activity Regulation Of Metabolic Process Radial Pattern Formation Putamen Development Caudate Nucleus Development Animal Organ Development Skeletal Muscle Tissue Development Regulation Of Heart Growth Negative Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Hypertrophy Forebrain Development Cell Differentiation Nucleus Cis-regulatory Region Sequence-specific DNA Binding