KLK2 and SERPINE1

Number of citations of the paper that reports this interaction (PubMedID 10209959)
0

Data Source:
HPRD (in vivo)

		KLK2	SERPINE1
Description		kallikrein related peptidase 2	serpin family E member 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Serine Protease Inhibitor Complex Peptidase Inhibitor Complex
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Peptidase Inhibitor Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Proteolysis Zymogen Activation	Angiogenesis Response To Bacterium Negative Regulation Of Plasminogen Activation Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Migration Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Fibrinolysis Positive Regulation Of Angiogenesis Negative Regulation Of Proteolysis Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Inflammatory Response Positive Regulation Of Coagulation Defense Response To Gram-negative Bacterium Negative Regulation Of Fibrinolysis Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Replicative Senescence Dentinogenesis Positive Regulation Of Odontoblast Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Integrin-mediated Signaling Pathway
Pathways		Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Platelet degranulation BMAL1:CLOCK,NPAS2 activates circadian expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription ECM proteoglycans Dissolution of Fibrin Clot Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Drugs			Alteplase Urokinase Reteplase Anistreplase Tenecteplase Drotrecogin alfa Troglitazone Colforsin Fibrinolysin Copper Bucladesine
Diseases			Inherited thrombophilia
GWAS		Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322 34012061) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)	Blood protein levels ( 30072576) Nonunion in individuals with fractures ( 30680360) Plasma plasminogen activator levels ( 24578379) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Interacting Genes		14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2	25 interacting genes: ACTN4 ELANE F2 HSD17B11 IGFBP5 KLK2 KRT18 LMNA LRP1 LRP1B LRP2 MMP3 ORM1 PITX1 PLAT PLAU PLG SGTA SGTB TLX3 TMEM237 UBQLN1 UBQLN2 UBQLN4 VTN
Entrez ID		3817	5054
HPRD ID		01006	01418
Ensembl ID		ENSG00000167751	ENSG00000106366
Uniprot IDs		A0A024R4J4 B4DU77 P20151	B7ZAB0 P05121
PDB IDs		4NFE 4NFF	1A7C 1B3K 1C5G 1DB2 1DVM 1DVN 1LJ5 1OC0 3CVM 3EOX 3PB1 3Q02 3Q03 3R4L 3UT3 4AQH 4G8O 4G8R 4IC0 5BRR 5ZLZ 6GWN 6GWP 6GWQ 6I8S 6ZRV 7AQF 7AQG 9PAI
Enriched GO Terms of Interacting Partners?		Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Protease Binding Extracellular Space Extracellular Exosome Extracellular Region Platelet Alpha Granule Lumen Extracellular Matrix Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Blood Microparticle Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Serine Protease Inhibitor Complex Endopeptidase Inhibitor Activity Negative Regulation Of Plasminogen Activation Regulation Of Proteolysis Signaling Receptor Binding Positive Regulation Of Endopeptidase Activity Antibacterial Humoral Response Regulation Of Blood Coagulation Regulation Of Hemostasis Positive Regulation Of Peptidase Activity Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Flagellated Sperm Motility Regulation Of Endopeptidase Activity Coagulation Platelet Alpha Granule Fibrinolysis Sperm Capacitation Defense Response To Bacterium Negative Regulation Of Protein Processing Positive Regulation Of Monocyte Chemotaxis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Maturation Molecular Function Activator Activity Regulation Of Wound Healing Positive Regulation Of Blood Coagulation Positive Regulation Of Chemotaxis Positive Regulation Of Coagulation Cell Maturation Regulation Of G Protein-coupled Receptor Signaling Pathway Antimicrobial Humoral Response Heparin Binding Regulation Of Monocyte Chemotaxis Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Bacterium Epithelial Cell Morphogenesis Positive Regulation Of Supramolecular Fiber Organization	Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Serine-type Endopeptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Fibrinolysis Serine-type Peptidase Activity Positive Regulation Of Wound Healing Regulation Of Proteolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Proteolysis Regulation Of Protein Metabolic Process Low-density Lipoprotein Particle Receptor Activity Regulation Of Wound Healing Negative Regulation Of Proteolysis TRC Complex Positive Regulation Of ERAD Pathway Peptidase Activity Extracellular Space Regulation Of Smooth Muscle Cell Migration Regulation Of Response To Wounding Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of ERAD Pathway Regulation Of Cell Migration Endopeptidase Activity Regulation Of Cell Motility Trans-synaptic Signaling By BDNF Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Locomotion Blood Coagulation Coagulation Neutrophil-mediated Killing Of Gram-negative Bacterium Hemostasis Positive Regulation Of Lysosomal Protein Catabolic Process Serine Protease Inhibitor Complex Biological Process Involved In Interaction With Symbiont Zymogen Activation Polyubiquitin Modification-dependent Protein Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Response To Endoplasmic Reticulum Stress Extracellular Matrix Blood Microparticle Negative Regulation Of Multicellular Organismal Process
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