KLK2 and SEMG2

Number of citations of the paper that reports this interaction (PMID 10411640)
7

Data Source:
HPRD (in vitro, in vivo)

		KLK2	SEMG2
Gene Name		kallikrein-related peptidase 2	semenogelin II
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome	Extracellular Space Nucleus Secretory Granule Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity	Structural Molecule Activity
	Biological Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization	Sexual Reproduction
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs
Diseases
GWAS		PCA3 expression level ( 23555189) Prostate-specific antigen levels ( 23359319)
Protein-Protein Interactions		14 interactors: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2	7 interactors: KLK2 KLK3 PRKAR2A PRKCA SEMG1 SERPINA5 TGM1
Entrez ID		3817	6407
HPRD ID		01006	01642
Ensembl ID		ENSG00000167751	ENSG00000124157
Uniprot IDs		B4DU77 P20151	Q02383
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Wound Healing Regulation Of Catalytic Activity Response To Wounding Platelet Activation Negative Regulation Of Plasminogen Activation Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Blood Coagulation Exocytosis Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Wound Healing Reproductive Process Transcription Initiation From RNA Polymerase II Promoter Fibrinolysis Positive Regulation Of Blood Coagulation Secretion By Cell Acute-phase Response Positive Regulation Of Coagulation Response To Stress DNA-templated Transcription, Initiation Positive Regulation Of Wound Healing Regulation Of Metabolic Process Secretion Mating Negative Regulation Of Blood Coagulation Cell Activation Regulation Of Inflammatory Response Negative Regulation Of Coagulation Negative Regulation Of Integrin Biosynthetic Process Regulation Of Blood Coagulation, Intrinsic Pathway	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Dense Core Granule Biogenesis Extracellular Matrix Disassembly Positive Regulation Of Inflammatory Response Regulation Of Blood Coagulation Factor XII Activation Cell Envelope Organization Histone H3-T6 Phosphorylation Regulation Of Wound Healing Negative Regulation Of Protein Serine/threonine Kinase Activity Energy Reserve Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Fibrinolysis Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Negative Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of Peptide Hormone Secretion Regulation Of Angiogenesis Neurotrophin Signaling Pathway Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Plasminogen Activation Regulation Of Hormone Secretion Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Inflammatory Response Plasma Kallikrein-kinin Cascade Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Glucose Import
Tagcloud ?		422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides pik3cg prostate proteases pseudogene repeats share silico talk
Tagcloud (Difference) ?		422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides pik3cg prostate proteases pseudogene repeats share silico talk
Tagcloud (Intersection) ?