KLK2 and SERPINB6

Number of citations of the paper that reports this interaction (PMID 10463585)
3

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		KLK2	SERPINB6
Gene Name		kallikrein-related peptidase 2	serpin peptidase inhibitor, clade B (ovalbumin), member 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Cytosol Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity	Protease Binding Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization	Negative Regulation Of Endopeptidase Activity
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Dissolution of Fibrin Clot
Drugs
Diseases
GWAS		PCA3 expression level ( 23555189) Prostate-specific antigen levels ( 23359319)
Protein-Protein Interactions		14 interactors: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2	6 interactors: F10 F2 KLK2 PLAU PLG PROC
Entrez ID		3817	5269
HPRD ID		01006	01413
Ensembl ID		ENSG00000167751	ENSG00000124570
Uniprot IDs		B4DU77 P20151	P35237
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Wound Healing Regulation Of Catalytic Activity Response To Wounding Platelet Activation Negative Regulation Of Plasminogen Activation Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Blood Coagulation Exocytosis Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Wound Healing Reproductive Process Transcription Initiation From RNA Polymerase II Promoter Fibrinolysis Positive Regulation Of Blood Coagulation Secretion By Cell Acute-phase Response Positive Regulation Of Coagulation Response To Stress DNA-templated Transcription, Initiation Positive Regulation Of Wound Healing Regulation Of Metabolic Process Secretion Mating Negative Regulation Of Blood Coagulation Cell Activation Regulation Of Inflammatory Response Negative Regulation Of Coagulation Negative Regulation Of Integrin Biosynthetic Process Regulation Of Blood Coagulation, Intrinsic Pathway	Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Peptidyl-glutamic Acid Carboxylation Regulation Of Blood Coagulation Blood Coagulation Hemostasis Regulation Of Wound Healing Fibrinolysis Regulation Of Body Fluid Levels Wound Healing Proteolysis Response To Wounding Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Post-translational Protein Modification Leukocyte Migration Cell Migration Positive Regulation Of Blood Coagulation Cell Motility Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Locomotion Protein Metabolic Process Movement Of Cell Or Subcellular Component Extracellular Matrix Disassembly Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To Stress Regulation Of Smooth Muscle Cell-matrix Adhesion Mononuclear Cell Migration Protein Activation Cascade Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Platelet Activation Regulation Of Cell-substrate Adhesion Peptidyl-amino Acid Modification Blood Coagulation, Extrinsic Pathway Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Astrocyte Differentiation Regulation Of Cell Proliferation Negative Regulation Of Platelet Activation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Trophoblast Giant Cell Differentiation Labyrinthine Layer Blood Vessel Development Muscle Cell Cellular Homeostasis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process
Tagcloud ?		422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides pik3cg prostate proteases pseudogene repeats share silico talk	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 tymp wars
Tagcloud (Difference) ?		422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides pik3cg prostate proteases pseudogene repeats share silico talk	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 tymp wars
Tagcloud (Intersection) ?