KLK2 and SERPINC1

Number of citations of the paper that reports this interaction (PMID 9428387)
8

Data Source:
HPRD (in vitro)

		KLK2	SERPINC1
Gene Name		kallikrein-related peptidase 2	serpin peptidase inhibitor, clade C (antithrombin), member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding
	Biological Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization	Response To Nutrient Blood Coagulation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Inflammatory Response Regulation Of Blood Coagulation, Intrinsic Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Common Pathway Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs			Ardeparin Fondaparinux sodium Heparin Enoxaparin Alpha-D-Mannose N-Formylmethionine Sulodexide Dalteparin Tinzaparin Nadroparin
Diseases
GWAS		PCA3 expression level ( 23555189) Prostate-specific antigen levels ( 23359319)
Protein-Protein Interactions		14 interactors: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2	5 interactors: F2 KLK2 KLK6 PLG SDC2
Entrez ID		3817	462
HPRD ID		01006	00122
Ensembl ID		ENSG00000167751	ENSG00000117601
Uniprot IDs		B4DU77 P20151	P01008
PDB IDs			1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH 3EVJ 3KCG 4EB1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Wound Healing Regulation Of Catalytic Activity Response To Wounding Platelet Activation Negative Regulation Of Plasminogen Activation Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Blood Coagulation Exocytosis Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Wound Healing Reproductive Process Transcription Initiation From RNA Polymerase II Promoter Fibrinolysis Positive Regulation Of Blood Coagulation Secretion By Cell Acute-phase Response Positive Regulation Of Coagulation Response To Stress DNA-templated Transcription, Initiation Positive Regulation Of Wound Healing Regulation Of Metabolic Process Secretion Mating Negative Regulation Of Blood Coagulation Cell Activation Regulation Of Inflammatory Response Negative Regulation Of Coagulation Negative Regulation Of Integrin Biosynthetic Process Regulation Of Blood Coagulation, Intrinsic Pathway	Negative Regulation Of Fibrinolysis Wound Healing Regulation Of Fibrinolysis Response To Wounding Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Tissue Regeneration Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Proteolysis Extracellular Matrix Disassembly Regulation Of Blood Coagulation Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Neurogenesis Regulation Of Wound Healing Regulation Of Cell Development Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Mononuclear Cell Migration Platelet Activation Protein Metabolic Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Leukocyte Migration Locomotion Developmental Growth Cell Differentiation Response To Stress Protein Autoprocessing Movement Of Cell Or Subcellular Component Regulation Of Neuron Projection Development Generation Of Neurons Regulation Of Cell Differentiation Peptidyl-glutamic Acid Carboxylation Blood Coagulation Neurogenesis Hemostasis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Platelet Activation Regulation Of Cell Morphogenesis Catabolic Process Regulation Of Cell Projection Organization Amyloid Precursor Protein Metabolic Process Growth
Tagcloud ?		422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides pik3cg prostate proteases pseudogene repeats share silico talk	antithrombin autosomal buccal budapest cct clade codon cover deep deficiency exons giving heterozygous inherited malay malaysia malaysian mucosal ncbi peptidase swabs thr thrombin thromboembolism thrombosis vte woman
Tagcloud (Difference) ?		422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides pik3cg prostate proteases pseudogene repeats share silico talk	antithrombin autosomal buccal budapest cct clade codon cover deep deficiency exons giving heterozygous inherited malay malaysia malaysian mucosal ncbi peptidase swabs thr thrombin thromboembolism thrombosis vte woman
Tagcloud (Intersection) ?