KLK2 and SERPINA3

Number of citations of the paper that reports this interaction (PMID 9428387)
8

Data Source:
HPRD (in vitro, in vivo)

		KLK2	SERPINA3
Gene Name		kallikrein-related peptidase 2	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Intracellular Nucleus Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization	Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs
Diseases
GWAS		PCA3 expression level ( 23555189) Prostate-specific antigen levels ( 23359319)	Body mass index ( 23669352)
Protein-Protein Interactions		14 interactors: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2	25 interactors: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1
Entrez ID		3817	12
HPRD ID		01006	00120
Ensembl ID		ENSG00000167751	ENSG00000196136
Uniprot IDs		B4DU77 P20151	G3V5I3 P01011
PDB IDs			1AS4 1QMN 2ACH 3CAA 3DLW 4CAA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Wound Healing Regulation Of Catalytic Activity Response To Wounding Platelet Activation Negative Regulation Of Plasminogen Activation Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Blood Coagulation Exocytosis Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Wound Healing Reproductive Process Transcription Initiation From RNA Polymerase II Promoter Fibrinolysis Positive Regulation Of Blood Coagulation Secretion By Cell Acute-phase Response Positive Regulation Of Coagulation Response To Stress DNA-templated Transcription, Initiation Positive Regulation Of Wound Healing Regulation Of Metabolic Process Secretion Mating Negative Regulation Of Blood Coagulation Cell Activation Regulation Of Inflammatory Response Negative Regulation Of Coagulation Negative Regulation Of Integrin Biosynthetic Process Regulation Of Blood Coagulation, Intrinsic Pathway	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Proteolysis Protein Metabolic Process Killing By Host Of Symbiont Cells Defense Response Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Inflammatory Response Metabolic Process Regulation Of Protein Metabolic Process Neutrophil Mediated Immunity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Stress Killing Of Cells Of Other Organism Wound Healing Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Central Nervous System Development Interaction With Symbiont Leukocyte Mediated Cytotoxicity Peptide Hormone Processing Response To Wounding Negative Regulation Of Cytokine Biosynthetic Process Response To Fungus Blood Coagulation Inflammatory Response Hemostasis Defense Response To Bacterium Negative Regulation Of Interleukin-12 Biosynthetic Process Interleukin-1 Beta Biosynthetic Process Neuromuscular Junction Development Response To Bacterium Regulation Of Angiogenesis Protein Processing Negative Regulation Of Growth Collagen Catabolic Process Facial Nucleus Development Leading Strand Elongation Factor XII Activation Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Platelet Degranulation Regulation Of Body Fluid Levels Regulation Of Translation Acute Inflammatory Response
Tagcloud ?		422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides pik3cg prostate proteases pseudogene repeats share silico talk	add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported
Tagcloud (Difference) ?		422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides pik3cg prostate pseudogene repeats share silico talk	add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment question remodeling resultsthe submitted supported
Tagcloud (Intersection) ?		proteases