TTR and CFTR

Number of citations of the paper that reports this interaction (PubMedID 35156780)
96

Data Source:
BioGRID (protein complementation assay)

		TTR	CFTR
Description		transthyretin	CF transmembrane conductance regulator
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Protein-containing Complex Azurophil Granule Lumen Extracellular Exosome	Nucleus Cytoplasm Lysosomal Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Golgi-associated Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Protein-containing Complex Chloride Channel Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Hormone Activity Protein Binding Hormone Binding Identical Protein Binding Protein-containing Complex Binding Molecular Sequestering Activity	Nucleotide Binding Chloride Channel Activity Intracellularly ATP-gated Chloride Channel Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Isomerase Activity ATP Hydrolysis Activity Chloride Channel Regulator Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Protein-folding Chaperone Binding 14-3-3 Protein Binding Sec61 Translocon Complex Binding ABC-type Transporter Activity
	Biological Process	Retinoid Metabolic Process Negative Regulation Of Glomerular Filtration Purine Nucleobase Metabolic Process Phototransduction, Visible Light	Cholesterol Biosynthetic Process Monoatomic Ion Transport Chloride Transport Water Transport Vesicle Docking Involved In Exocytosis Bicarbonate Transport Cholesterol Transport Monoatomic Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress Transepithelial Water Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Exocytosis Sperm Capacitation Multicellular Organismal-level Water Homeostasis Intracellular PH Elevation Establishment Of Localization In Cell Transmembrane Transport Membrane Hyperpolarization Regulation Of Biological Quality Positive Regulation Of Enamel Mineralization Cellular Response To CAMP Amelogenesis Inorganic Ion Transmembrane Transport Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity Cellular Response To Forskolin
Pathways		The canonical retinoid cycle in rods (twilight vision) Non-integrin membrane-ECM interactions Neutrophil degranulation Retinoid metabolism and transport Amyloid fiber formation Defective visual phototransduction due to STRA6 loss of function	ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOQ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy Developmental Lineage of Pancreatic Ductal Cells
Drugs		Zinc Copper Tafamidis Zinc acetate Zinc chloride Zinc sulfate, unspecified form Revusiran	ATP Bumetanide Glyburide Ibuprofen Genistein Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor
Diseases		Familial carpal tunnel syndrome Familial amyloidosis	Hereditary pancreatitis; Hereditary chronic pancreatitis Cystic fibrosis (CF) Congenital bilateral absence of vas deferens
GWAS		Retinol levels ( 21878437)	Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Glaucoma ( 30054594) Gout ( 22179738) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Type 1 diabetes ( 34012112) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		50 interacting genes: A2M ACTB AGER APOA1 ATF4 ATF5 BAG6 CDR2 CEP126 CFTR CHD3 CLU CPNE6 CTNND2 DDR1 EEF1A1 ELP1 ERG28 FEZ1 GET3 GET4 HNRNPH3 HSP90AA1 HSPG2 INPP5K LRP2 MARK3 MT3 NDUFA5 NECAB2 NGFR OTUB1 PHYHIP PIK3R1 PRKCI QARS1 RAI1 RBP4 RNF115 SDF4 SETDB1 SP110 ST13 ST3GAL3 SUMO3 TAF1C TAF5L TUBA1A VIM ZBED1	466 interacting genes: A4GALT AARSD1 ABCC11 ABRAXAS1 ACCS ACOT8 ACRV1 ADAMTS1 ADAT1 ADCYAP1 ADRB3 AFMID AGBL4 AGO3 AHCYL1 AK8 AKR7A3 ALDOC ALKBH7 ANKRD49 ANKS3 ANTXR2 AP5B1 APOC2 AQP4-AS1 ARFGAP3 ARHGAP8 ARHGEF9 ARMC9 ASIC4 ASPDH ATOSB BACH1 BCAS1 BDH2 BEND5 BHLHA15 BICDL2 C19orf38 C1orf162 C7 C8orf33 C9orf43 CAB39L CABCOCO1 CALHM5 CALM2 CAMKK1 CAMKV CANX CAP1 CAPZB CASP1 CASQ2 CBR4 CCDC110 CCDC146 CCDC167 CCDC197 CCDC66 CCDC9 CCNYL6 CD22 CD68 CEP55 CFHR5 CGB2 CGB3 CGB5 CGB8 CGREF1 CHCHD10 CHMP2B CHRFAM7A CHRM4 CHRNA7 CHST14 CHST5 CIMIP5 CLCN3 CLCNKB CLEC10A CLEC12A CLEC7A CLIC1 COASY COL21A1 COL23A1 COL9A1 COPG1 COX18 CRABP1 CRACR2B CREB3L1 CSHL1 CSNK1G2-AS1 CUL1 CUTC CWC22 CYB561D1 CYP4F12 DACH2 DARS2 DAZ3 DAZ4 DDRGK1 DDX19A DDX20 DEF8 DEFB119 DEGS1 DERL1 DHX30 DLX6 DNAJA1 DNAJB14 DNAJC1 DNAJC5 DOCK10 DPF3 DPP7 DPPA3 DQX1 DRG1 DSTN DUSP7 EDF1 EEIG1 EFCAB11 EGLN3 EIF4E3 EMG1 ENPP5 EPHX1 EPO ERCC6L EREG ERICH5 ERMAP ETFA EVL EZR FAAP100 FABP2 FAM153CP FAM222A FAM9C FANCB FASTKD2 FBXO11 FCGR3A FCHO1 FGD5 FGL2 FHL2 FKBP6 FKBP6P2 FKBP7 FMOD FNIP1 FNTA GABRG2 GADD45B GAREM1 GCKR GCLM GDAP2 GFOD3P GGA1 GIMAP4 GINM1 GINS3 GNAS GNAZ GNB2 GOPC GPX1 GSDME GSTO1 GSTT2 GSTT2B GTF2F1 H2BC7 HACL1 HAND2-AS1 HAUS4 HDDC3 HEYL HHIPL2 HINT2 HK1 HMMR HNMT HOMER3 HSD17B2 HSP90AA1 HSPA14 HSPD1 HTATIP2 HTR5A IGKC IGKV1-5 IGKV2-24 IGLV4-3 IKZF2 IL12RB1 IL13 IL36A INHBA INIP INTU IQUB ISOC1 ITM2C JADE1 KATNAL1 KIF12 KLHDC7B KLHL18 KLK14 KPNA5 KRT13 KRT31 KRTAP26-1 LCMT1 LGALS14 LGALS2 LGALS9 LIAS LINC03042 LLCFC1 LMBR1L LMX1B LPCAT4 LRFN4 LRRC37B LRRC57 LSP1 LUM LURAP1L MAGEB2 MAGEC3 MAN1A1 MAP3K19 MARCHF2 MC3R MCCC2 MCPH1 MED11 MEIOB MELTF METTL14 METTL2A MGAT5B MGP MIER2 MORN3 MOS MPI MREG MRPS27 MSH4 MTFR2 MTMR14 MTRES1 MYADM MYEOV MYLK2 MYOG NAA10 NCCRP1 NEU4 NFAM1 NFIL3 NHERF1 NHERF2 NHERF4 NHLH2 NHS NIT2 NOD1 NOP53 NRIP3 NUDT1 OLFM4 OPTN OR5M8 OR7E91P OSTM1 OTC OTUD6A P2RY6 PBDC1 PBX3 PBX4 PCP4L1 PDHA1 PDIA3 PDS5B PDZK1 PGAP2 PIK3R5 PISD PLEKHB2 PNMA1 PNP POGLUT3 POLE POLR1F POU5F1 PPP1R21 PPP2R1B PRAF2 PRDM1 PRDM4 PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 PROKR1 PRSS45P PSMD4 PTCD1 PTTG1 PVRIG PWP2 PYROXD1 RASL10B RBM14 RDH12 RDH13 RFFL RFWD3 RGS13 RND3 RNF139 RNF5 RPS6KB2 RRS1 SAMD3 SAMD4B SAXO4 SCAMP1 SCN2B SDHA SDR9C7 SEC22C SEMA3E SERAC1 SERPINA3 SERPINA4 SERPINB10 SERPIND1 SERPING1 SH3BP4 SHC1 SLC10A1 SLC10A6 SLC14A1 SLC25A51P4 SLC26A11 SLC33A1 SLC35B4 SLC38A7 SLC44A5 SLC4A7 SLC4A8 SLC66A1LP SLC7A10 SLC9A6 SLC9B1 SMARCD1 SMIM21 SMYD1 SMYD3 SNAP23 SNRPN SORBS3 SOX15 SPATA6L SPEF1 SPSB3 SRP68 ST6GALNAC1 STAP2 STAU1 STIMATE STK26 STRADA STUB1 STX1A SYNE4 SYT12 TAFA3 TAFAZZIN TASL TBP TCTN3 TFEB TFF2 TFG TFR2 TGFB1 TGS1 THAP11 TIMD4 TK1 TLCD4 TLR3 TMEM237 TMEM277P TMEM40 TMPRSS6 TNFSF10 TONSL TOR1B TRAFD1 TRIM16 TRIM16L TRIM27 TRIM32 TRIM5 TRMT1 TSC22D1 TTR TXNRD2 UBE2I ULK3 UNC119 UNC45B UNC93B1 USP10 USP26 USP28 VAMP4 VAPA VAPB VASN VAV1 VDAC2 VEGFA VEPH1 VPS28 VPS4A VPS4B VTI1B WDR5B WWP2 XAGE3 XKR8 YTHDF1 ZBED2 ZC2HC1B ZDHHC15 ZFP57 ZFYVE26 ZGRF1 ZNF112 ZNF213 ZNF22 ZNF462 ZNF69 ZNF770 ZUP1
Entrez ID		7276	1080
HPRD ID		01447	03883
Ensembl ID		ENSG00000118271	ENSG00000001626
Uniprot IDs		E9KL36 P02766	P13569
PDB IDs		1BM7 1BMZ 1BZ8 1BZD 1BZE 1DVQ 1DVS 1DVT 1DVU 1DVX 1DVY 1DVZ 1E3F 1E4H 1E5A 1ETA 1ETB 1F41 1F86 1FH2 1FHN 1G1O 1GKO 1ICT 1III 1IIK 1IJN 1QAB 1QWH 1RLB 1SOK 1SOQ 1THA 1THC 1TLM 1TSH 1TT6 1TTA 1TTB 1TTC 1TTR 1TYR 1TZ8 1U21 1X7S 1X7T 1Y1D 1Z7J 1ZCR 1ZD6 2B14 2B15 2B16 2B77 2B9A 2F7I 2F8I 2FBR 2FLM 2G3X 2G3Z 2G4E 2G4G 2G5U 2G9K 2GAB 2H4E 2M5N 2NBO 2NBP 2NOY 2PAB 2QEL 2QGB 2QGC 2QGD 2QGE 2ROX 2ROY 2TRH 2TRY 2WQA 3A4D 3A4E 3A4F 3B56 3BSZ 3BT0 3CBR 3CFM 3CFN 3CFQ 3CFT 3CN0 3CN1 3CN2 3CN3 3CN4 3CXF 3D2T 3D7P 3DGD 3DID 3DJR 3DJS 3DJT 3DJZ 3DK0 3DK2 3DO4 3ESN 3ESO 3ESP 3FC8 3FCB 3GLZ 3GPS 3GRB 3GRG 3GS0 3GS4 3GS7 3HJ0 3I9A 3I9I 3I9P 3IMR 3IMS 3IMT 3IMU 3IMV 3IMW 3IPB 3IPE 3KGS 3KGT 3KGU 3M1O 3NEE 3NEO 3NES 3NEX 3NG5 3OZK 3OZL 3P3R 3P3S 3P3T 3P3U 3SSG 3TCT 3TFB 3U2I 3U2J 3W3B 4ABQ 4ABU 4ABV 4ABW 4AC2 4AC4 4ACT 4ANK 4D7B 4DER 4DES 4DET 4DEU 4DEW 4FI6 4FI7 4FI8 4HIQ 4HIS 4HJS 4HJT 4HJU 4I85 4I87 4I89 4IIZ 4IK6 4IK7 4IKI 4IKJ 4IKK 4IKL 4KY2 4L1S 4L1T 4MAS 4MRB 4MRC 4N85 4N86 4N87 4PM1 4PME 4PMF 4PVL 4PVM 4PVN 4PWE 4PWF 4PWG 4PWH 4PWI 4PWJ 4PWK 4QRF 4QXV 4QYA 4TKW 4TL4 4TL5 4TLK 4TLS 4TLT 4TLU 4TM9 4TNE 4TNF 4TNG 4TQ8 4TQH 4TQI 4TQP 4WNJ 4WNS 4WO0 4Y9B 4Y9C 4Y9E 4Y9F 4Y9G 4YDM 4YDN 5A6I 5AKS 5AKT 5AKV 5AL0 5AL8 5AYT 5BOJ 5CLX 5CLY 5CLZ 5CM1 5CN3 5CNH 5CR1 5DEJ 5DWP 5E23 5E4A 5E4O 5EN3 5EZP 5FO2 5FW6 5FW7 5FW8 5H0V 5H0W 5H0X 5H0Y 5H0Z 5HJG 5IHH 5JID 5JIM 5JIQ 5K1J 5K1N 5L4F 5L4I 5L4J 5L4M 5LLL 5LLV 5N5Q 5N62 5N7C 5NFE 5NFW 5OQ0 5TTR 5TZL 5U48 5U49 5U4A 5U4B 5U4C 5U4D 5U4E 5U4F 5U4G 6D0W 6E6Z 6E70 6E71 6E72 6E73 6E74 6E75 6E76 6E77 6E78 6EOY 6EP1 6FFT 6FWD 6FXU 6FZL 6GR7 6GRP 6IMX 6IMY 6KGB 6R66 6R67 6R68 6R6I 6SDZ 6SUG 6SUH 6TI9 6TJN 6TXV 6TXW 6U0Q 6XTK 7ACU 7DT3 7DT5 7DT6 7DT8 7EJQ 7EJR 7ERH 7ERI 7ERJ 7ERK 7OB4 7Q3I 7Q9L 7Q9N 7Q9O 7QC5 7THA 7W9Q 7W9R 7WL6 7Y1I 7Y6J 7YBR 7YCQ 7Z60 8ADE 8AWI 8AWW 8C85 8C86 8E7D 8E7E 8E7H 8E7I 8E7J 8G9R 8GBR 8HEJ 8HY4 8I00 8I0O 8IG1 8II1 8II2 8II3 8II4 8JNU 8JOK 8JQW 8PKE 8PKF 8PKG 8PM8 8PM9 8PMA 8PMO 8T5X 8TDN 8TDO 8U52 8VE0 8VE1 8VE2 8VE3 8VE4 8VE5 8VE6 8W1N 8W2W 8W42 8W43 8W44 8W45 8W46 8W47 8W48 8WGS 8WGT 8WGU 8YQD 9BYN 9BZS 9H7A 9H7B 9H7C 9H7D 9H7E 9H7F 9H7G 9H7H 9H7I 9H7J 9H7K 9H7L 9H7M 9H7N 9H7O 9H7P 9JIQ 9JIR 9JIS	1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW 4WZ6 5D2D 5D3E 5D3F 5TF7 5TF8 5TFA 5TFB 5TFC 5TFD 5TFF 5TFG 5TFI 5TFJ 5TGK 5UAK 6GJQ 6GJS 6GJU 6GK4 6GKD 6HEP 6MSM 6O1V 6O2P 6UK1 6WBS 6ZE1 7QI1 7SV7 7SVD 7SVR 8EIG 8EIO 8EIQ 8EJ1 8FZQ 8GLS 8UBR 8V7Z 8V81 9DW4 9DW5 9DW7 9DW8 9DW9
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Protein Carrier Chaperone Amyloid-beta Binding Tau Protein Binding Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Transport Cytoplasm BAT3 Complex Regulation Of Protein Localization Maintenance Of Unfolded Protein Protein Stabilization Protein Binding Regulation Of Protein Stability Protein Insertion Into ER Membrane Regulation Of Protein Localization To Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Localization Regulation Of Primary Metabolic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Cellular Response To Stress Axon Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Cellular Component Organization Cell Projection Regulation Of Programmed Cell Death Nitric-oxide Synthase Regulator Activity Regulation Of Metabolic Process Cell Projection Organization Spherical High-density Lipoprotein Particle Sterol Biosynthetic Process Negative Regulation Of Programmed Cell Death Protein-folding Chaperone Binding Vitamin Transport Positive Regulation Of Protein Localization Carbohydrate Homeostasis Glucose Homeostasis Vagina Development Blood Microparticle Cellular Response To Amyloid-beta Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Brush Border Regulation Of Multicellular Organismal Development Response To Endoplasmic Reticulum Stress Circadian Rhythm Kinase Activator Activity ATP Hydrolysis Activity Developmental Process Negative Regulation Of Complement Activation
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