TTR and AGER

Number of citations of the paper that reports this interaction (PubMedID 16716307)
0

Data Source:
HPRD (in vitro)

		TTR	AGER
Description		transthyretin	advanced glycosylation end-product specific receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Protein-containing Complex Azurophil Granule Lumen Extracellular Exosome	Fibrillar Center Phagocytic Cup Extracellular Region Nucleus Endosome Early Endosome Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Cell Junction Cell Projection Postsynapse
	Molecular Function	Hormone Activity Protein Binding Hormone Binding Identical Protein Binding Protein-containing Complex Binding Molecular Sequestering Activity	Amyloid-beta Binding DNA Binding RNA Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Laminin Receptor Activity Protein Binding Signaling Receptor Activity Histone Binding Identical Protein Binding S100 Protein Binding Protein-containing Complex Binding Advanced Glycation End-product Receptor Activity Molecular Adaptor Activity
	Biological Process	Retinoid Metabolic Process Negative Regulation Of Glomerular Filtration Purine Nucleobase Metabolic Process Phototransduction, Visible Light	Response To Hypoxia Microglial Cell Activation Positive Regulation Of Cytokine Production Regulation Of T Cell Mediated Cytotoxicity DNA Replication DNA Repair Phagocytosis Inflammatory Response DNA Damage Response Cell Adhesion Cell Surface Receptor Signaling Pathway Learning Or Memory Positive Regulation Of Cell Population Proliferation Response To Wounding Negative Regulation Of Biosynthetic Process Glucose Mediated Signaling Pathway Astrocyte Development Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Interleukin-10 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Activated T Cell Proliferation Transcytosis Positive Regulation Of Cell Differentiation Positive Regulation Of JNK Cascade Astrocyte Activation Regulation Of Synaptic Plasticity Regulation Of Inflammatory Response Induction Of Positive Chemotaxis Positive Regulation Of DNA Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Protein Localization To Membrane Regulation Of Spontaneous Synaptic Transmission Transport Across Blood-brain Barrier Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Depression Regulation Of P38MAPK Cascade Positive Regulation Of P38MAPK Cascade Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Blood Circulation Positive Regulation Of Endothelin Production Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Response To Amyloid-beta Cellular Response To Amyloid-beta Positive Regulation Of DNA-templated DNA Replication Positive Regulation Of Monocyte Extravasation Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Double-strand Break Repair Positive Regulation Of Dendritic Cell Differentiation
Pathways		The canonical retinoid cycle in rods (twilight vision) Non-integrin membrane-ECM interactions Neutrophil degranulation Retinoid metabolism and transport Amyloid fiber formation Defective visual phototransduction due to STRA6 loss of function	TAK1-dependent IKK and NF-kappa-B activation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs		Zinc Copper Tafamidis Zinc acetate Zinc chloride Zinc sulfate, unspecified form Revusiran
Diseases		Familial carpal tunnel syndrome Familial amyloidosis
GWAS		Retinol levels ( 21878437)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels in cardiovascular risk ( 28369058) Chronic obstructive pulmonary disease ( 33909500 30804561 28166215) Emphysema imaging phenotypes ( 26030696) FEV1 ( 30804560) Inflammatory bowel disease ( 28067908) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Percentage gas trapping ( 26030696) Prostate cancer ( 23535732) Pulmonary function ( 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Response to Pazopanib in cancer (hepatotoxicity) ( 26546620) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Soluble receptor for advanced glycation end-product levels ( 26083729) Ulcerative colitis ( 28067908)
Interacting Genes		50 interacting genes: A2M ACTB AGER APOA1 ATF4 ATF5 BAG6 CDR2 CEP126 CFTR CHD3 CLU CPNE6 CTNND2 DDR1 EEF1A1 ELP1 ERG28 FEZ1 GET3 GET4 HNRNPH3 HSP90AA1 HSPG2 INPP5K LRP2 MARK3 MT3 NDUFA5 NECAB2 NGFR OTUB1 PHYHIP PIK3R1 PRKCI QARS1 RAI1 RBP4 RNF115 SDF4 SETDB1 SP110 ST13 ST3GAL3 SUMO3 TAF1C TAF5L TUBA1A VIM ZBED1	10 interacting genes: APP C3orf52 CMTM7 CREB3 HMGB1 S100A1 S100A12 S100B S100P TTR
Entrez ID		7276	177
HPRD ID		01447	02568
Ensembl ID		ENSG00000118271	ENSG00000204305
Uniprot IDs		E9KL36 P02766	A0A1U9X785 B4DNX3 Q101R3 Q15109
PDB IDs		1BM7 1BMZ 1BZ8 1BZD 1BZE 1DVQ 1DVS 1DVT 1DVU 1DVX 1DVY 1DVZ 1E3F 1E4H 1E5A 1ETA 1ETB 1F41 1F86 1FH2 1FHN 1G1O 1GKO 1ICT 1III 1IIK 1IJN 1QAB 1QWH 1RLB 1SOK 1SOQ 1THA 1THC 1TLM 1TSH 1TT6 1TTA 1TTB 1TTC 1TTR 1TYR 1TZ8 1U21 1X7S 1X7T 1Y1D 1Z7J 1ZCR 1ZD6 2B14 2B15 2B16 2B77 2B9A 2F7I 2F8I 2FBR 2FLM 2G3X 2G3Z 2G4E 2G4G 2G5U 2G9K 2GAB 2H4E 2M5N 2NBO 2NBP 2NOY 2PAB 2QEL 2QGB 2QGC 2QGD 2QGE 2ROX 2ROY 2TRH 2TRY 2WQA 3A4D 3A4E 3A4F 3B56 3BSZ 3BT0 3CBR 3CFM 3CFN 3CFQ 3CFT 3CN0 3CN1 3CN2 3CN3 3CN4 3CXF 3D2T 3D7P 3DGD 3DID 3DJR 3DJS 3DJT 3DJZ 3DK0 3DK2 3DO4 3ESN 3ESO 3ESP 3FC8 3FCB 3GLZ 3GPS 3GRB 3GRG 3GS0 3GS4 3GS7 3HJ0 3I9A 3I9I 3I9P 3IMR 3IMS 3IMT 3IMU 3IMV 3IMW 3IPB 3IPE 3KGS 3KGT 3KGU 3M1O 3NEE 3NEO 3NES 3NEX 3NG5 3OZK 3OZL 3P3R 3P3S 3P3T 3P3U 3SSG 3TCT 3TFB 3U2I 3U2J 3W3B 4ABQ 4ABU 4ABV 4ABW 4AC2 4AC4 4ACT 4ANK 4D7B 4DER 4DES 4DET 4DEU 4DEW 4FI6 4FI7 4FI8 4HIQ 4HIS 4HJS 4HJT 4HJU 4I85 4I87 4I89 4IIZ 4IK6 4IK7 4IKI 4IKJ 4IKK 4IKL 4KY2 4L1S 4L1T 4MAS 4MRB 4MRC 4N85 4N86 4N87 4PM1 4PME 4PMF 4PVL 4PVM 4PVN 4PWE 4PWF 4PWG 4PWH 4PWI 4PWJ 4PWK 4QRF 4QXV 4QYA 4TKW 4TL4 4TL5 4TLK 4TLS 4TLT 4TLU 4TM9 4TNE 4TNF 4TNG 4TQ8 4TQH 4TQI 4TQP 4WNJ 4WNS 4WO0 4Y9B 4Y9C 4Y9E 4Y9F 4Y9G 4YDM 4YDN 5A6I 5AKS 5AKT 5AKV 5AL0 5AL8 5AYT 5BOJ 5CLX 5CLY 5CLZ 5CM1 5CN3 5CNH 5CR1 5DEJ 5DWP 5E23 5E4A 5E4O 5EN3 5EZP 5FO2 5FW6 5FW7 5FW8 5H0V 5H0W 5H0X 5H0Y 5H0Z 5HJG 5IHH 5JID 5JIM 5JIQ 5K1J 5K1N 5L4F 5L4I 5L4J 5L4M 5LLL 5LLV 5N5Q 5N62 5N7C 5NFE 5NFW 5OQ0 5TTR 5TZL 5U48 5U49 5U4A 5U4B 5U4C 5U4D 5U4E 5U4F 5U4G 6D0W 6E6Z 6E70 6E71 6E72 6E73 6E74 6E75 6E76 6E77 6E78 6EOY 6EP1 6FFT 6FWD 6FXU 6FZL 6GR7 6GRP 6IMX 6IMY 6KGB 6R66 6R67 6R68 6R6I 6SDZ 6SUG 6SUH 6TI9 6TJN 6TXV 6TXW 6U0Q 6XTK 7ACU 7DT3 7DT5 7DT6 7DT8 7EJQ 7EJR 7ERH 7ERI 7ERJ 7ERK 7OB4 7Q3I 7Q9L 7Q9N 7Q9O 7QC5 7THA 7W9Q 7W9R 7WL6 7Y1I 7Y6J 7YBR 7YCQ 7Z60 8ADE 8AWI 8AWW 8C85 8C86 8E7D 8E7E 8E7H 8E7I 8E7J 8G9R 8GBR 8HEJ 8HY4 8I00 8I0O 8IG1 8II1 8II2 8II3 8II4 8JNU 8JOK 8JQW 8PKE 8PKF 8PKG 8PM8 8PM9 8PMA 8PMO 8T5X 8TDN 8TDO 8U52 8VE0 8VE1 8VE2 8VE3 8VE4 8VE5 8VE6 8W1N 8W2W 8W42 8W43 8W44 8W45 8W46 8W47 8W48 8WGS 8WGT 8WGU 8YQD 9BYN 9BZS 9H7A 9H7B 9H7C 9H7D 9H7E 9H7F 9H7G 9H7H 9H7I 9H7J 9H7K 9H7L 9H7M 9H7N 9H7O 9H7P 9JIQ 9JIR 9JIS	2E5E 2ENS 2L7U 2LE9 2LMB 2M1K 2MJW 2MOV 3CJJ 3O3U 4LP4 4LP5 4OF5 4OFV 4OI7 4OI8 4P2Y 4XYN 4YBH 5D7F 6VXG 6XQ1 6XQ3 6XQ5 6XQ6 6XQ7 6XQ8 6XQ9 7LML 7LMW 8I9M
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Protein Carrier Chaperone Amyloid-beta Binding Tau Protein Binding Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Transport Cytoplasm BAT3 Complex Regulation Of Protein Localization Maintenance Of Unfolded Protein Protein Stabilization Protein Binding Regulation Of Protein Stability Protein Insertion Into ER Membrane Regulation Of Protein Localization To Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Localization Regulation Of Primary Metabolic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Cellular Response To Stress Axon Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Cellular Component Organization Cell Projection Regulation Of Programmed Cell Death Nitric-oxide Synthase Regulator Activity Regulation Of Metabolic Process Cell Projection Organization Spherical High-density Lipoprotein Particle Sterol Biosynthetic Process Negative Regulation Of Programmed Cell Death Protein-folding Chaperone Binding Vitamin Transport Positive Regulation Of Protein Localization Carbohydrate Homeostasis Glucose Homeostasis Vagina Development Blood Microparticle Cellular Response To Amyloid-beta Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Brush Border Regulation Of Multicellular Organismal Development Response To Endoplasmic Reticulum Stress Circadian Rhythm Kinase Activator Activity ATP Hydrolysis Activity Developmental Process Negative Regulation Of Complement Activation	RAGE Receptor Binding Calcium-dependent Protein Binding Positive Regulation Of Monocyte Chemotaxis Chemotaxis Regulation Of Monocyte Chemotaxis Locomotion Identical Protein Binding Endothelial Cell Migration Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Protein Homodimerization Activity S100 Protein Binding Extracellular Region Secretory Granule Lumen Myeloid Leukocyte Activation Transition Metal Ion Binding Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Sprouting Angiogenesis Chemoattractant Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Chemotaxis Regulation Of System Process Leukocyte Activation Regulation Of Leukocyte Migration Calcium Ion Binding Positive Chemotaxis Cell Activation Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response To Fungus Response To Fungus Positive Regulation Of Interleukin-1 Beta Production Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Regulation Of Sprouting Angiogenesis Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Deacetylase Activity Macrophage Activation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Extracellular Space Acetylcholine Receptor Activator Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?