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TTR and PIK3R1
Number of citations of the paper that reports this interaction (PubMedID
18624398
)
0
Data Source:
BioGRID
(two hybrid)
TTR
PIK3R1
Description
transthyretin
phosphoinositide-3-kinase regulatory subunit 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytoplasm
Protein-containing Complex
Azurophil Granule Lumen
Extracellular Exosome
Nucleus
Cytoplasm
Cis-Golgi Network
Cytosol
Plasma Membrane
Cell-cell Junction
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Membrane
Perinuclear Region Of Cytoplasm
Perinuclear Endoplasmic Reticulum Membrane
Molecular Function
Hormone Activity
Protein Binding
Hormone Binding
Identical Protein Binding
Protein-containing Complex Binding
Molecular Sequestering Activity
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
GTPase Activator Activity
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Kinase Regulator Activity
Kinase Activator Activity
Protein Phosphatase Binding
Phosphatidylinositol 3-kinase Regulator Activity
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
ErbB-3 Class Receptor Binding
Phosphatidylinositol 3-kinase Binding
Insulin Binding
Insulin Receptor Substrate Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Protein Heterodimerization Activity
Phosphatidylinositol Kinase Activity
Enzyme-substrate Adaptor Activity
Phosphatidylinositol 3-kinase Activator Activity
Biological Process
Retinoid Metabolic Process
Negative Regulation Of Glomerular Filtration
Purine Nucleobase Metabolic Process
Phototransduction, Visible Light
Intracellular Glucose Homeostasis
Negative Regulation Of Cell-matrix Adhesion
Positive Regulation Of Leukocyte Migration
Transcription By RNA Polymerase II
Protein Import Into Nucleus
Immune Response
Negative Regulation Of Cell Adhesion
Signal Transduction
Insulin Receptor Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Lamellipodium Assembly
Protein Transport
Cytokine-mediated Signaling Pathway
B Cell Differentiation
T Cell Differentiation
Osteoclast Differentiation
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Insulin Stimulus
Positive Regulation Of RNA Splicing
Regulation Of Toll-like Receptor 4 Signaling Pathway
Substrate Adhesion-dependent Cell Spreading
Cellular Response To UV
Response To Endoplasmic Reticulum Stress
Interleukin-18-mediated Signaling Pathway
Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of Apoptotic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of D-glucose Import
Phosphatidylinositol Phosphate Biosynthetic Process
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Protein Stabilization
Positive Regulation Of Filopodium Assembly
Regulation Of Stress Fiber Assembly
Negative Regulation Of Stress Fiber Assembly
Growth Hormone Receptor Signaling Pathway
T Follicular Helper Cell Differentiation
Myeloid Leukocyte Migration
Positive Regulation Of Focal Adhesion Disassembly
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Protein Localization To Plasma Membrane
Pathways
The canonical retinoid cycle in rods (twilight vision)
Non-integrin membrane-ECM interactions
Neutrophil degranulation
Retinoid metabolism and transport
Amyloid fiber formation
Defective visual phototransduction due to STRA6 loss of function
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PI3K events in ERBB4 signaling
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
GAB1 signalosome
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
PI3K events in ERBB2 signaling
PI3K/AKT activation
Signaling by ALK
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
GP1b-IX-V activation signalling
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
RET signaling
RHOA GTPase cycle
Extra-nuclear estrogen signaling
RHOB GTPase cycle
RHOC GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Activated NTRK2 signals through PI3K
RHOF GTPase cycle
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Activated NTRK3 signals through PI3K
FLT3 Signaling
FLT3 Signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by CSF1 (M-CSF) in myeloid cells
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
Signaling by FLT3 fusion proteins
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Signaling by FLT3 ITD and TKD mutants
Signaling by ALK fusions and activated point mutants
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Signaling by LTK in cancer
Signaling by LTK
Co-stimulation by ICOS
Drugs
Zinc
Copper
Tafamidis
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Revusiran
SF1126
Enzastaurin
Wortmannin
Diseases
Familial carpal tunnel syndrome
Familial amyloidosis
GWAS
Retinol levels (
21878437
)
Alzheimer's disease biomarkers (
23419831
)
Anthropometric traits (multi-trait analysis) (
30166351
)
Appendicular lean mass (
33097823
)
Basal cell carcinoma (
33549134
)
Birth weight (
31043758
)
Body fat percentage and HDL-C (pairwise) (
33619380
)
Bone mineral density (hip) (
26911590
)
Corneal astigmatism (
30306274
)
Crohn's disease (
32581322
)
Estimated glomerular filtration rate (
30604766
31152163
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
HDL cholesterol levels (
32203549
)
Height (
31562340
)
Hip minimal joint space width (
27701424
)
Intelligence (MTAG) (
29326435
)
Leg fat mass (lean adjusted) (
32719433
)
Leg fat mass and leg lean mass (pleiotropy) (
32719433
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Menarche (age at onset) (
23599027
)
Offspring birth weight (
31043758
)
Red cell distribution width (
32888494
27863252
)
Rosacea symptom severity (
29771307
)
Triglyceride levels (
32203549
29083408
)
Type 2 diabetes (adjusted for BMI) (
30297969
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
50 interacting genes:
A2M
ACTB
AGER
APOA1
ATF4
ATF5
BAG6
CDR2
CEP126
CFTR
CHD3
CLU
CPNE6
CTNND2
DDR1
EEF1A1
ELP1
ERG28
FEZ1
GET3
GET4
HNRNPH3
HSP90AA1
HSPG2
INPP5K
LRP2
MARK3
MT3
NDUFA5
NECAB2
NGFR
OTUB1
PHYHIP
PIK3R1
PRKCI
QARS1
RAI1
RBP4
RNF115
SDF4
SETDB1
SP110
ST13
ST3GAL3
SUMO3
TAF1C
TAF5L
TUBA1A
VIM
ZBED1
180 interacting genes:
ABL1
ADAM12
ADAMTS2
AGAP2
AKT1
ALK
ANK3
APPL1
AR
ARAF
ARHGAP1
ARHGAP17
ARHGAP32
AXL
BCAR1
BLK
BRCA1
CBL
CBLB
CCL14
CD19
CD22
CD28
CD2AP
CD3E
CD4
CD40
CD5
CD7
CDC42
CDH2
CHRNA7
CIP2A
CLNK
CRK
CRKL
CSF1R
CSF2RA
CTLA4
CTNNB1
CXCL2
CYP4A11
DLX2
DNM1
DOK1
EGF
EGFR
ENKUR
EPHA2
EPOR
ERAS
ERBB2
ERBB3
ERBB4
ESR1
EZR
FASLG
FBXO21
FCGR2A
FER
FES
FGFR1
FLT1
FYN
GAB1
GAB2
GAB3
GHR
GP1BA
GRB2
GSPT1
GTF2H1
HCK
HCST
HGS
HOXA1
HRAS
HTT
IFNAR1
IGF1R
IKZF3
IL13
IL1R1
IL1RAP
IL2RB
IL7R
INPP4A
INSR
IRS1
IRS2
IRS4
ITSN1
JAK1
JAK2
JAK3
KBTBD2
KHDRBS1
KIT
LAT
LCK
LNX2
LRRK2
MAPK8
MAPT
MET
MME
MST1R
MYO16
NFKBIA
NLRP6
NTRK1
NTRK2
NUP85
NYAP1
NYAP2
PASK
PDE4D
PDGFB
PDGFRA
PDGFRB
PECAM1
PFN1
PIK3AP1
PIK3CA
PIK3CB
PIK3CD
PPM1A
PRMT8
PROM1
PSEN1
PSMB5
PTEN
PTK2
PTK2B
PTPN11
PTPN6
RAC1
RASA1
RASD2
RB1
RET
RRAS2
SH3KBP1
SHB
SHC1
SLC9A2
SOCS1
SOCS6
SOCS7
SQSTM1
SRC
SSTR2
STAT3
SYK
SYN1
TEC
TEK
TGFBR1
TGFBR2
TIE1
TLR2
TNK2
TNS4
TOM1L1
TRAT1
TRIM25
TSHR
TTR
TUB
TUBA1B
TUBG1
TXK
TYK2
TYRO3
VAV1
VAV3
WAS
WASF3
WBP11
YWHAG
Entrez ID
7276
5295
HPRD ID
01447
01381
Ensembl ID
ENSG00000118271
ENSG00000145675
Uniprot IDs
E9KL36
P02766
A0A2X0SFG1
P27986
PDB IDs
1BM7
1BMZ
1BZ8
1BZD
1BZE
1DVQ
1DVS
1DVT
1DVU
1DVX
1DVY
1DVZ
1E3F
1E4H
1E5A
1ETA
1ETB
1F41
1F86
1FH2
1FHN
1G1O
1GKO
1ICT
1III
1IIK
1IJN
1QAB
1QWH
1RLB
1SOK
1SOQ
1THA
1THC
1TLM
1TSH
1TT6
1TTA
1TTB
1TTC
1TTR
1TYR
1TZ8
1U21
1X7S
1X7T
1Y1D
1Z7J
1ZCR
1ZD6
2B14
2B15
2B16
2B77
2B9A
2F7I
2F8I
2FBR
2FLM
2G3X
2G3Z
2G4E
2G4G
2G5U
2G9K
2GAB
2H4E
2M5N
2NBO
2NBP
2NOY
2PAB
2QEL
2QGB
2QGC
2QGD
2QGE
2ROX
2ROY
2TRH
2TRY
2WQA
3A4D
3A4E
3A4F
3B56
3BSZ
3BT0
3CBR
3CFM
3CFN
3CFQ
3CFT
3CN0
3CN1
3CN2
3CN3
3CN4
3CXF
3D2T
3D7P
3DGD
3DID
3DJR
3DJS
3DJT
3DJZ
3DK0
3DK2
3DO4
3ESN
3ESO
3ESP
3FC8
3FCB
3GLZ
3GPS
3GRB
3GRG
3GS0
3GS4
3GS7
3HJ0
3I9A
3I9I
3I9P
3IMR
3IMS
3IMT
3IMU
3IMV
3IMW
3IPB
3IPE
3KGS
3KGT
3KGU
3M1O
3NEE
3NEO
3NES
3NEX
3NG5
3OZK
3OZL
3P3R
3P3S
3P3T
3P3U
3SSG
3TCT
3TFB
3U2I
3U2J
3W3B
4ABQ
4ABU
4ABV
4ABW
4AC2
4AC4
4ACT
4ANK
4D7B
4DER
4DES
4DET
4DEU
4DEW
4FI6
4FI7
4FI8
4HIQ
4HIS
4HJS
4HJT
4HJU
4I85
4I87
4I89
4IIZ
4IK6
4IK7
4IKI
4IKJ
4IKK
4IKL
4KY2
4L1S
4L1T
4MAS
4MRB
4MRC
4N85
4N86
4N87
4PM1
4PME
4PMF
4PVL
4PVM
4PVN
4PWE
4PWF
4PWG
4PWH
4PWI
4PWJ
4PWK
4QRF
4QXV
4QYA
4TKW
4TL4
4TL5
4TLK
4TLS
4TLT
4TLU
4TM9
4TNE
4TNF
4TNG
4TQ8
4TQH
4TQI
4TQP
4WNJ
4WNS
4WO0
4Y9B
4Y9C
4Y9E
4Y9F
4Y9G
4YDM
4YDN
5A6I
5AKS
5AKT
5AKV
5AL0
5AL8
5AYT
5BOJ
5CLX
5CLY
5CLZ
5CM1
5CN3
5CNH
5CR1
5DEJ
5DWP
5E23
5E4A
5E4O
5EN3
5EZP
5FO2
5FW6
5FW7
5FW8
5H0V
5H0W
5H0X
5H0Y
5H0Z
5HJG
5IHH
5JID
5JIM
5JIQ
5K1J
5K1N
5L4F
5L4I
5L4J
5L4M
5LLL
5LLV
5N5Q
5N62
5N7C
5NFE
5NFW
5OQ0
5TTR
5TZL
5U48
5U49
5U4A
5U4B
5U4C
5U4D
5U4E
5U4F
5U4G
6D0W
6E6Z
6E70
6E71
6E72
6E73
6E74
6E75
6E76
6E77
6E78
6EOY
6EP1
6FFT
6FWD
6FXU
6FZL
6GR7
6GRP
6IMX
6IMY
6KGB
6R66
6R67
6R68
6R6I
6SDZ
6SUG
6SUH
6TI9
6TJN
6TXV
6TXW
6U0Q
6XTK
7ACU
7DT3
7DT5
7DT6
7DT8
7EJQ
7EJR
7ERH
7ERI
7ERJ
7ERK
7OB4
7Q3I
7Q9L
7Q9N
7Q9O
7QC5
7THA
7W9Q
7W9R
7WL6
7Y1I
7Y6J
7YBR
7YCQ
7Z60
8ADE
8AWI
8AWW
8C85
8C86
8E7D
8E7E
8E7H
8E7I
8E7J
8G9R
8GBR
8HEJ
8HY4
8I00
8I0O
8IG1
8II1
8II2
8II3
8II4
8JNU
8JOK
8JQW
8PKE
8PKF
8PKG
8PM8
8PM9
8PMA
8PMO
8T5X
8TDN
8TDO
8U52
8VE0
8VE1
8VE2
8VE3
8VE4
8VE5
8VE6
8W1N
8W2W
8W42
8W43
8W44
8W45
8W46
8W47
8W48
8WGS
8WGT
8WGU
8YQD
9BYN
9BZS
9H7A
9H7B
9H7C
9H7D
9H7E
9H7F
9H7G
9H7H
9H7I
9H7J
9H7K
9H7L
9H7M
9H7N
9H7O
9H7P
9JIQ
9JIR
9JIS
1A0N
1AZG
1H9O
1PBW
1PHT
1PIC
1PKS
1PKT
2IUG
2IUH
2IUI
2RD0
2V1Y
3HHM
3HIZ
3I5R
3I5S
4A55
4JPS
4L1B
4L23
4L2Y
4OVU
4OVV
4WAF
4YKN
4ZOP
5AUL
5FI4
5GJI
5ITD
5M6U
5SW8
5SWG
5SWO
5SWP
5SWR
5SWT
5SX8
5SX9
5SXA
5SXB
5SXC
5SXD
5SXE
5SXF
5SXI
5SXJ
5SXK
5UBT
5UK8
5UKJ
5UL1
5VLR
5XGH
5XGI
5XGJ
6NCT
6PYR
6PYU
7CIO
7LM2
7LQ1
7MYN
7MYO
7PG5
7PG6
7RNS
7TZ7
8AM0
8DCP
8DCX
8DD4
8DD8
8GUB
8H36
8H37
8ILR
8ILS
8ILV
8SBC
8SBJ
8TDU
8TGD
8TS7
8TS8
8TS9
8TSA
8TSB
8TSC
8TSD
8TU6
8V8H
8V8I
8V8J
8V8U
8V8V
8W9A
8W9B
Enriched GO Terms of Interacting Partners
?
Extracellular Exosome
Protein Carrier Chaperone
Amyloid-beta Binding
Tau Protein Binding
Tail-anchored Membrane Protein Insertion Into ER Membrane
Positive Regulation Of Transport
Cytoplasm
BAT3 Complex
Regulation Of Protein Localization
Maintenance Of Unfolded Protein
Protein Stabilization
Protein Binding
Regulation Of Protein Stability
Protein Insertion Into ER Membrane
Regulation Of Protein Localization To Nucleus
Regulation Of Macromolecule Metabolic Process
Regulation Of Cellular Localization
Regulation Of Primary Metabolic Process
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Cellular Response To Stress
Axon
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Cellular Component Organization
Cell Projection
Regulation Of Programmed Cell Death
Nitric-oxide Synthase Regulator Activity
Regulation Of Metabolic Process
Cell Projection Organization
Spherical High-density Lipoprotein Particle
Sterol Biosynthetic Process
Negative Regulation Of Programmed Cell Death
Protein-folding Chaperone Binding
Vitamin Transport
Positive Regulation Of Protein Localization
Carbohydrate Homeostasis
Glucose Homeostasis
Vagina Development
Blood Microparticle
Cellular Response To Amyloid-beta
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Brush Border
Regulation Of Multicellular Organismal Development
Response To Endoplasmic Reticulum Stress
Circadian Rhythm
Kinase Activator Activity
ATP Hydrolysis Activity
Developmental Process
Negative Regulation Of Complement Activation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Plasma Membrane
Regulation Of Signal Transduction
Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Regulation Of Immune System Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Immune System Process
Protein Kinase Activity
Regulation Of Immune Response
Kinase Activity
Positive Regulation Of Multicellular Organismal Process
Transmembrane Receptor Protein Tyrosine Kinase Activity
Immune Response-activating Cell Surface Receptor Signaling Pathway
Phosphorylation
Immune Response-regulating Signaling Pathway
Regulation Of MAPK Cascade
Positive Regulation Of Cell Population Proliferation
Protein Phosphorylation
Receptor Complex
Positive Regulation Of MAPK Cascade
Intracellular Signaling Cassette
Regulation Of Cell Population Proliferation
Regulation Of Cell Activation
Antigen Receptor-mediated Signaling Pathway
Immune Response-activating Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Immune Response
Cell Migration
Cytokine-mediated Signaling Pathway
Protein Autophosphorylation
Regulation Of Developmental Process
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell Migration
Activation Of Immune Response
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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