TTR and ST3GAL3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		TTR	ST3GAL3
Gene Name		transthyretin	ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Protein Complex Extracellular Vesicular Exosome	Golgi Membrane Extracellular Region Integral Component Of Golgi Membrane Golgi Cisterna Membrane
	Molecular Function	Hormone Activity Protein Binding Identical Protein Binding Protein Heterodimerization Activity Thyroid Hormone Binding	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity
	Biological Process	Retinoid Metabolic Process Transport Phototransduction, Visible Light Extracellular Matrix Organization Retinol Metabolic Process Thyroid Hormone Transport	Carbohydrate Metabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process Protein O-linked Glycosylation Pathogenesis O-glycan Processing Keratan Sulfate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process Sialylation
Pathways		Amyloids Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Retinoid cycle disease events Non-integrin membrane-ECM interactions Diseases associated with visual transduction Retinoid metabolism and transport	Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective MGAT2 causes MGAT2-CDG (CDG-2a) O-linked glycosylation Defective CHST14 causes EDS, musculocontractural type Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases Defective ALG2 causes ALG2-CDG (CDG-1i) Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective EXT2 causes exostoses 2 Signaling by NOTCH Termination of O-glycan biosynthesis Synthesis of substrates in N-glycan biosythesis Asparagine N-linked glycosylation MPS IV - Morquio syndrome A Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Metabolism of carbohydrates O-linked glycosylation of mucins Diseases associated with N-glycosylation of proteins MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective SLC26A2 causes chondrodysplasias Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective PAPSS2 causes SEMD-PA Defective MAN1B1 causes MRT15 MPS IIIA - Sanfilippo syndrome A Pre-NOTCH Expression and Processing Defective ALG11 causes ALG11-CDG (CDG-1p) MPS IIIC - Sanfilippo syndrome C Pre-NOTCH Processing in Golgi Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome
Drugs
Diseases
GWAS		Retinol levels ( 21878437)	Aging (time to event) ( 21782286) Amyotrophic lateral sclerosis (age of onset) ( 22959728)
Protein-Protein Interactions		46 interactors: A2M ACTB AGER APOA1 ASNA1 ATF4 BAG6 C14orf1 CDR2 CHD3 CLU CPNE6 CTNND2 DDR1 EEF1A1 FEZ1 GET4 HNRNPH3 HSPG2 IKBKAP INPP5K KIAA1377 LRP2 MARK3 MT3 NECAB2 NGFR OTUB1 PHYHIP PIK3R1 PRKCI QARS RAI1 RBP4 RNF115 SDF4 SETDB1 SP110 ST13 ST3GAL3 SUMO3 TAF1C TAF5L TUBA1A VIM ZBED1	5 interactors: ACTG1 RPL8 SCAMP2 TTR ZBTB5
Entrez ID		7276	6487
HPRD ID		01447	05930
Ensembl ID		ENSG00000118271	ENSG00000126091
Uniprot IDs		E9KL36 P02766	B4DX62 Q11203
PDB IDs		1BM7 1BMZ 1BZ8 1BZD 1BZE 1DVQ 1DVS 1DVT 1DVU 1DVX 1DVY 1DVZ 1E3F 1E4H 1E5A 1ETA 1ETB 1F41 1F64 1F86 1FH2 1FHN 1G1O 1GKO 1ICT 1III 1IIK 1IJN 1QAB 1QWH 1RLB 1SOK 1SOQ 1THA 1THC 1TLM 1TSH 1TT6 1TTA 1TTB 1TTC 1TTR 1TYR 1TZ8 1U21 1X7S 1X7T 1Y1D 1Z7J 1ZCR 1ZD6 2B14 2B15 2B16 2B77 2B9A 2F7I 2F8I 2FBR 2FLM 2G3X 2G3Z 2G4E 2G4G 2G5U 2G9K 2GAB 2H4E 2M5N 2NOY 2PAB 2QEL 2QGB 2QGC 2QGD 2QGE 2ROX 2ROY 2TRH 2TRY 2WQA 3A4D 3A4E 3A4F 3B56 3BSZ 3BT0 3CBR 3CFM 3CFN 3CFQ 3CFT 3CN0 3CN1 3CN2 3CN3 3CN4 3CXF 3D2T 3D7P 3DGD 3DID 3DJR 3DJS 3DJT 3DJZ 3DK0 3DK2 3DO4 3ESN 3ESO 3ESP 3FC8 3FCB 3GLZ 3GPS 3GRB 3GRG 3GS0 3GS4 3GS7 3HJ0 3I9A 3I9I 3I9P 3IMR 3IMS 3IMT 3IMU 3IMV 3IMW 3IPB 3IPE 3KGS 3KGT 3KGU 3M1O 3NEE 3NEO 3NES 3NEX 3NG5 3OZK 3OZL 3P3R 3P3S 3P3T 3P3U 3SSG 3TCT 3TFB 3U2I 3U2J 3W3B 4ABQ 4ABU 4ABV 4ABW 4AC2 4AC4 4ACT 4ANK 4DER 4DES 4DET 4DEU 4DEW 4FI6 4FI7 4FI8 4HIQ 4HIS 4I85 4I87 4I89 4IIZ 4IK6 4IK7 4IKI 4IKJ 4IKK 4IKL 4KY2 4L1S 4L1T 4MAS 5TTR
Enriched GO Terms of Interacting Partners?		Protein Insertion Into ER Membrane Anatomical Structure Development Developmental Process Protein Stabilization Protein Metabolic Process Cellular Protein Metabolic Process Multicellular Organismal Development Regulation Of Protein Stability Nervous System Development Central Nervous System Development Regulation Of Gene Expression Protein Insertion Into Membrane System Development Cellular Localization Phototransduction, Visible Light Retinoid Metabolic Process Detection Of Abiotic Stimulus Diterpenoid Metabolic Process Detection Of Visible Light Cellular Response To Stimulus Platelet Activation Phototransduction Response To Light Stimulus Chromatin Organization Regulation Of Glucose Transport Alcohol Metabolic Process Detection Of Light Stimulus Organelle Organization Establishment Of Protein Localization To Membrane Metabolic Process Lipid Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Metabolic Process Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Cellular Metabolic Process Isoprenoid Metabolic Process Response To Organic Substance Endoplasmic Reticulum Organization Chromatin Modification Regulation Of Cellular Protein Metabolic Process Membrane Organization Response To Radiation Negative Regulation Of Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Response To Wounding Signaling Regulation Of Glucose Import Cellular Protein Modification Process
Tagcloud ?		arteriovenous carotid clamped conscious constant cooled cooling degree depend destined driving extrahypothalamic gain goats hypothalamic hypothalamus loops manipulate passage rete sbc shunt tbr temperatures termed texh thermodes thyp trunk
Tagcloud (Difference) ?		arteriovenous carotid clamped conscious constant cooled cooling degree depend destined driving extrahypothalamic gain goats hypothalamic hypothalamus loops manipulate passage rete sbc shunt tbr temperatures termed texh thermodes thyp trunk
Tagcloud (Intersection) ?