AHCY and APPBP2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		AHCY	APPBP2
Gene Name		adenosylhomocysteinase	amyloid beta precursor protein (cytoplasmic tail) binding protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Melanosome Neuron Projection Extracellular Vesicular Exosome	Nucleus Cytoplasm Microtubule Microtubule Associated Complex Cytoplasmic Vesicle Membrane
	Molecular Function	Adenosylhomocysteinase Activity Adenyl Nucleotide Binding Identical Protein Binding	Microtubule Motor Activity Protein Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Response To Hypoxia Chronic Inflammatory Response To Antigenic Stimulus One-carbon Metabolic Process Xenobiotic Metabolic Process Response To Nutrient S-adenosylhomocysteine Catabolic Process Methylation S-adenosylmethionine Cycle Cellular Nitrogen Compound Metabolic Process Circadian Sleep/wake Cycle Small Molecule Metabolic Process Homocysteine Biosynthetic Process	Intracellular Protein Transport Metabolic Process Intracellular Transport
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Sulfur amino acid metabolism Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Metabolism of amino acids and derivatives Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Nicotinamide-Adenine-Dinucleotide (1\'r,2\'s)-9-(2-Hydroxy-3\'-Keto-Cyclopenten-1-Yl)Adenine 3\'-Oxo-Adenosine D-Eritadenine
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ANKRD40 APPBP2 C1orf50 POT1 PXN TERF1 YWHAQ	79 interactors: AHCY AIM2 AK3 ANKRD10 APP AR ARMCX5 C1orf50 C6orf226 CALM3 CCDC85C CCNL1 CDK16 CHMP5 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CTC1 DCD DHRS2 DPEP1 EID3 EPT1 ERO1L FAM19A4 FAM92A1 FSTL1 FXYD7 GALNT3 GCSAM GP9 GSTP1 HIPK4 HIST1H2AK HSPA4 KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MFSD3 MGC34796 MLLT3 MUL1 NFYA NPRL3 PCSK5 PI4KAP2 PPP1R8 PRKAA2 PRKACB PYROXD2 RASSF5 RNF128 RNF34 RRS1 SELV SLC22A6 SLC25A23 SNX5 ST8SIA5 SYNRG SYT11 TAF11 TBL3 TCF25 UBE2R2 UGGT2 WAS WDR24 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		191	10513
HPRD ID		01621	05616
Ensembl ID		ENSG00000101444	ENSG00000062725
Uniprot IDs		P23526	Q92624
PDB IDs		1A7A 1LI4 3NJ4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Positive Regulation Of Organelle Organization Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Strand Elongation Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Cellular Component Organization Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase Telomere Maintenance Via Telomere Shortening Regulation Of Organelle Organization Regulation Of Chromosome Organization Telomere Capping Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase DNA Replication Replicative Cell Aging Negative Regulation Of Transferase Activity Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Negative Regulation Of Biosynthetic Process Positive Regulation Of Microtubule Polymerization Signal Complex Assembly Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Microtubule Polymerization Focal Adhesion Assembly Positive Regulation Of Transferase Activity Cellular Component Assembly Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process	Regulation Of Defense Response To Virus By Host Response To Stress Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Homocysteine Metabolic Process Cellular Response To Organic Substance
Tagcloud ?		advantageous altered biomarkers candidates crc differentially discover earlier intensities labeled lgals1 mining nbs near nitrobenzenesulfenyl occurring pair paired peaks profiling proteome proteomic quantified ran rcn1 stroma validated vim zyx	10kb arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Difference) ?		advantageous altered biomarkers candidates crc differentially discover earlier intensities labeled lgals1 mining nbs near nitrobenzenesulfenyl occurring pair paired peaks profiling proteome proteomic quantified ran rcn1 stroma validated vim zyx	10kb arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Intersection) ?