AHCY and C1orf50

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology)

		AHCY	C1orf50
Name		adenosylhomocysteinase	chromosome 1 open reading frame 50
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Melanosome Extracellular Exosome	Cellular_component
	Molecular Function	Adenosylhomocysteinase Activity Protein Binding Hydrolase Activity	Protein Binding Identical Protein Binding
	Biological Process	One-carbon Metabolic Process S-adenosylmethionine Cycle	Biological_process
Pathways		Methylation Sulfur amino acid metabolism Metabolism of ingested SeMet, Sec, MeSec into H2Se Defective AHCY causes HMAHCHD	None
Drugs		(1'R,2'S)-9-(2-Hydroxy-3'-Keto-Cyclopenten-1-yl)Adenine 3'-Oxo-Adenosine D-Eritadenine Copper	None
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency	None
GWAS		Fish- and plant-related diet ( 32066663 ) Heel bone mineral density ( 30598549 ) Height ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) Vitiligo ( 27723757 ) Walking pace ( 33128006 )	No GWAS studies recorded
Interacting Genes		11 interacting genes: APPBP2 C1orf50 CEBPA FXR1 HSPA13 POT1 PXN TERF1 UBC UFL1 YWHAQ	14 interacting genes: ADCY4 AHCY APPBP2 CRX EIF2B1 EPM2AIP1 INCA1 LRP2BP MEOX1 MEOX2 NTAQ1 REL TCF4 UBC
Entrez ID		191	79078
HPRD ID		01621	14714
Ensembl ID		ENSG00000101444	ENSG00000164008
Uniprot IDs		A0A384MTQ3 P23526	Q9BV19
PDB IDs		1A7A 1LI4 3NJ4 4PFJ 4PGF 4YVF 5W49 5W4B	Not available
GO Terms Enriched among Interactors		Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Microtubule Associated Complex Negative Regulation Of Telomere Maintenance RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly UFM1 Ligase Activity Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Response To Vitamin B2 C/EBP Complex Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication UFM1 Transferase Activity Positive Regulation Of Telomeric Loop Disassembly Nucleus Negative Regulation Of Cell Cycle Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process CHOP-C/EBP Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cytoplasmic Stress Granule Positive Regulation Of Reticulophagy 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Inflammatory Response White Fat Cell Proliferation Regulation Of Telomere Maintenance	Somite Specification DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Segment Specification Somite Development Nucleus DNA-binding Transcription Factor Activity