AHCY and UFL1

Number of citations: 54 (PubMedID 32545848)
Data Source: BioGRID (two hybrid)

		AHCY	UFL1
Name		adenosylhomocysteinase	UFM1 specific ligase 1
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Melanosome Extracellular Exosome	Nucleus Chromosome Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Protein-containing Complex Site Of Double-strand Break Neuron Projection
	Molecular Function	Adenosylhomocysteinase Activity Protein Binding Hydrolase Activity	Protein Binding Transferase Activity Protein Kinase Binding UFM1 Ligase Activity UFM1 Transferase Activity
	Biological Process	One-carbon Metabolic Process S-adenosylmethionine Cycle	DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Osteoblast Differentiation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA Repair DNA Damage Response Blood Circulation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Autophagy Erythrocyte Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Disassembly Regulation Of Protein Localization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NLRP3 Inflammasome Complex Assembly Regulation Of Inflammatory Response Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Hematopoietic Stem Cell Differentiation Positive Regulation Of Glial Cell Proliferation Reticulophagy Protein Ufmylation Rescue Of Stalled Ribosome Antiviral Innate Immune Response Positive Regulation Of Reticulophagy Negative Regulation Of Signal Transduction By P53 Class Mediator Response To L-glutamate Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of IRE1-mediated Unfolded Protein Response Protein K69-linked Ufmylation
Pathways		Methylation Sulfur amino acid metabolism Metabolism of ingested SeMet, Sec, MeSec into H2Se Defective AHCY causes HMAHCHD	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		(1'R,2'S)-9-(2-Hydroxy-3'-Keto-Cyclopenten-1-yl)Adenine 3'-Oxo-Adenosine D-Eritadenine Copper	None
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency	None
GWAS		Fish- and plant-related diet ( 32066663 ) Heel bone mineral density ( 30598549 ) Height ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) Vitiligo ( 27723757 ) Walking pace ( 33128006 )	Diastolic blood pressure ( 27841878 ) Headache ( 29397368 ) Language functional connectivity ( 34929384 ) Migraine ( 27322543 ) Migraine without aura ( 27322543 ) Night sleep phenotypes ( 27126917 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 ) Triglyceride levels ( 32203549 ) Walking pace ( 33128006 )
Novel Interactors		1 novel interactors: RBFOX1	None recorded
Interacting Genes		11 interacting genes: APPBP2 C1orf50 CEBPA FXR1 HSPA13 POT1 PXN TERF1 UBC UFL1 YWHAQ	17 interacting genes: AHCY AKAP17A ATP4A ENY2 FGB H2AC4 HINFP IRAK1BP1 IRF3 MT1M PPIL1 PTPRO TIPRL TP53 TSC22D3 UFC1 ZNF219
Entrez ID		191	23376
HPRD ID		01621	11109
Ensembl ID		ENSG00000101444	ENSG00000014123
Uniprot IDs		A0A384MTQ3 P23526	O94874
PDB IDs		1A7A 1LI4 3NJ4 4PFJ 4PGF 4YVF 5W49 5W4B	8B9X 8C0D 8OHD 8OJ0 8OJ5 8OJ8 8QFC 8QFD
GO Terms Enriched among Interactors		Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Microtubule Associated Complex Negative Regulation Of Telomere Maintenance RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly UFM1 Ligase Activity Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Response To Vitamin B2 C/EBP Complex Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication UFM1 Transferase Activity Positive Regulation Of Telomeric Loop Disassembly Nucleus Negative Regulation Of Cell Cycle Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process CHOP-C/EBP Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cytoplasmic Stress Granule Positive Regulation Of Reticulophagy 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Inflammatory Response White Fat Cell Proliferation Regulation Of Telomere Maintenance	None