AHCY

Description		adenosylhomocysteinase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Melanosome Extracellular Exosome
	Molecular Function	Adenosylhomocysteinase Activity Protein Binding Hydrolase Activity
	Biological Process	One-carbon Metabolic Process S-adenosylmethionine Cycle
Pathways		Methylation Sulfur amino acid metabolism Metabolism of ingested SeMet, Sec, MeSec into H2Se Defective AHCY causes HMAHCHD
Drugs		(1'R,2'S)-9-(2-Hydroxy-3'-Keto-Cyclopenten-1-yl)Adenine 3'-Oxo-Adenosine D-Eritadenine Copper
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		Fish- and plant-related diet ( 32066663) Heel bone mineral density ( 30598549) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Vitiligo ( 27723757) Walking pace ( 33128006)
Novel Interacting Genes		1 novel interacting genes: RBFOX1
Interacting Genes		11 interacting genes: APPBP2 C1orf50 CEBPA FXR1 HSPA13 POT1 PXN TERF1 UBC UFL1 YWHAQ
Entrez ID		191
HPRD ID		01621
Ensembl ID		ENSG00000101444
Uniprot IDs		A0A384MTQ3 P23526
PDB IDs		1A7A 1LI4 3NJ4 4PFJ 4PGF 4YVF 5W49 5W4B
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Microtubule Associated Complex Negative Regulation Of Telomere Maintenance RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly UFM1 Ligase Activity Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Response To Vitamin B2 C/EBP Complex Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication UFM1 Transferase Activity Positive Regulation Of Telomeric Loop Disassembly Nucleus Negative Regulation Of Cell Cycle Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process CHOP-C/EBP Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cytoplasmic Stress Granule Positive Regulation Of Reticulophagy 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Inflammatory Response White Fat Cell Proliferation Regulation Of Telomere Maintenance
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