DVL1 and LRRK2

Number of citations of the paper that reports this interaction (PMID 19625296)
24

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		DVL1	LRRK2
Gene Name		dishevelled segment polarity protein 1	leucine-rich repeat kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Cytoplasmic Membrane-bounded Vesicle Lateral Plasma Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Neuronal Cell Body Synapse	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Lysosome Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Inclusion Body Axon Dendrite Cytoplasmic Vesicle Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Dendrite Cytoplasm Neuron Projection Neuronal Cell Body Terminal Bouton Perikaryon Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Frizzled Binding Protein Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Rac GTPase Binding	SNARE Binding Glycoprotein Binding Actin Binding GTPase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Tubulin Binding Kinase Activity Rho GTPase Binding Syntaxin-1 Binding Clathrin Binding GTP-dependent Protein Kinase Activity Peroxidase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Ion Channel Binding Protein Kinase A Binding
	Biological Process	Regulation Of Neurotransmitter Levels Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Neurotransmitter Secretion Axon Guidance Heart Development Neuromuscular Junction Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Positive Regulation Of Wnt Signaling Pathway Cytoplasmic Microtubule Organization Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Receptor Clustering Positive Regulation Of Transcription, DNA-templated Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Endocytosis Autophagy Response To Oxidative Stress Small GTPase Mediated Signal Transduction Neuromuscular Junction Development Determination Of Adult Lifespan Positive Regulation Of Autophagy Regulation Of Protein Kinase A Signaling Negative Regulation Of Protein Processing Regulation Of Neuron Maturation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Olfactory Bulb Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Positive Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of GTPase Activity Cellular Response To Oxidative Stress Cellular Protein Localization Intracellular Signal Transduction Regulation Of Kidney Size Exploration Behavior Locomotory Exploration Behavior Regulation Of Locomotion Regulation Of Membrane Potential Positive Regulation Of Programmed Cell Death Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Protein Autophosphorylation Intracellular Distribution Of Mitochondria Neuron Projection Morphogenesis Regulation Of Mitochondrial Depolarization Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Dendritic Spine Morphogenesis Protein Localization To Mitochondrion Neuron Death Cellular Response To Manganese Ion Reactive Oxygen Species Metabolic Process Regulation Of Mitochondrial Fission Regulation Of Neuron Death Negative Regulation Of Neuron Death Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Autoubiquitination Regulation Of Neuroblast Proliferation Regulation Of Synaptic Vesicle Transport Negative Regulation Of Late Endosome To Lysosome Transport Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Cellular Response To Dopamine Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Peroxidase Activity
Pathways		disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Crohn's disease ( 18587394 21102463) Inflammatory bowel disease ( 23128233) Obesity-related traits ( 23251661) Parkinson's disease ( 21292315 19915576 22438815 21738487)
Protein-Protein Interactions		35 interactors: ANXA7 ARRB1 ATN1 AXIN1 BRD7 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FRAT1 HDHD2 HECW1 LRRK2 NCK2 NEDD4 PPM1A PSMA3 RAC1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 TRIM69 USP13 VANGL1 VANGL2	33 interactors: ACTB AKT1 ARFGAP1 ARHGEF7 BAG5 DVL1 DVL2 DVL3 EIF4EBP1 HSPD1 L3MBTL3 LRP6 MAP1B MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPT MBP PRKCZ PTPN23 RALYL RIPK2 SH3GL1 SH3GL2 SH3GL3 STK24 STK25 STK3 STRBP TAOK3 TRAF2 TUBA1A
Entrez ID		1855	120892
HPRD ID		03220	10613
Ensembl ID		ENSG00000107404	ENSG00000188906
Uniprot IDs		O14640 Q86TH3	Q17RV3 Q5S007
PDB IDs			2ZEJ 3D6T
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Signal Transduction Regulation Of Cellular Component Organization Regulation Of Cell Morphogenesis Regulation Of Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Embryonic Pattern Specification Positive Regulation Of Protein Catabolic Process Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Modification Process SMAD Protein Complex Assembly Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cellular Metabolic Process Signaling Regulation Of Proteasomal Protein Catabolic Process Cell Communication Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Stem Cell Differentiation Embryonic Axis Specification Regulation Of Phosphorus Metabolic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Kidney Development	Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Regulation Of JNK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of JNK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Anatomical Structure Development Signal Transduction By Phosphorylation Regulation Of Catalytic Activity Regulation Of MAP Kinase Activity Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Signaling Regulation Of Intracellular Signal Transduction Cell Communication Positive Regulation Of Catalytic Activity Positive Regulation Of Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Signal Transduction Cell Death Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Developmental Process Regulation Of Signaling Activation Of Innate Immune Response
Tagcloud ?		1p36 1q36 20p12 2q37 accumulating boy brachydactyly chr1 chr2 chr20 cnv cnvs coarctation deleted deletion digit duplications dysmorphism facial gpcpd1 hdac4 intellectual malformations p36 pcrs phenotypes simply syndromic tumorigenic	autosomal decline difficulty dj1 england g2019s gait gu hoehn idiopathic leucine motor movement parkinson pd pigd pink1 postural prkn rating schwab snca society staging udrs undefined unified updrs yahr
Tagcloud (Difference) ?		1p36 1q36 20p12 2q37 accumulating boy brachydactyly chr1 chr2 chr20 cnv cnvs coarctation deleted deletion digit duplications dysmorphism facial gpcpd1 hdac4 intellectual malformations p36 pcrs phenotypes simply syndromic tumorigenic	autosomal decline difficulty dj1 england g2019s gait gu hoehn idiopathic leucine motor movement parkinson pd pigd pink1 postural prkn rating schwab snca society staging udrs undefined unified updrs yahr
Tagcloud (Intersection) ?