DVL1 and DAAM1

Number of citations of the paper that reports this interaction (PubMedID 11779461)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		DVL1	DAAM1
Description		dishevelled segment polarity protein 1	dishevelled associated activator of morphogenesis 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse Neuronal Dense Core Vesicle Wnt Signalosome	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Motile Cilium Ciliary Basal Body Cell Projection Synapse Perinuclear Region Of Cytoplasm Presynapse Glutamatergic Synapse
	Molecular Function	Frizzled Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Small GTPase Binding Identical Protein Binding	Actin Binding Protein Binding Small GTPase Binding Identical Protein Binding
	Biological Process	Heart Looping Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Neurotransmitter Secretion Axonogenesis Axon Guidance Neuromuscular Junction Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Synaptic Vesicle Exocytosis Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Cytoplasmic Microtubule Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Receptor Clustering Positive Regulation Of Transcription By RNA Polymerase II Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Protein Stabilization Convergent Extension Involved In Organogenesis Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Dendritic Spine Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Cochlea Morphogenesis Presynapse Assembly Postsynapse Organization Regulation Of Postsynapse Organization Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Protein Localization To Presynapse Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Wnt Signaling Pathway Actin Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Presynaptic Actin Cytoskeleton Organization
Pathways		TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	PCP/CE pathway RHO GTPases Activate Formins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 28067908) Nicotine dependence ( 32281736) Ulcerative colitis ( 28067908)	Brain morphology (MOSTest) ( 32665545) Cortical surface area ( 32963231) Cortical surface area (visual PC2) ( 32198502) Cortical thickness ( 32963231) Cortical volume ( 32963231) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Inferior temporal gyrus volume ( 31530798) Left–right brain asymmetry ( 33723403) Occipital lobe volume ( 31396565) Optic disc size ( 31809533) Parietal lobe volume ( 31396565) Parkinsonism in frontotemporal lobe dementia ( 29724592) Type 2 diabetes ( 25483131)
Interacting Genes		45 interacting genes: ANXA7 ARRB1 ATN1 AXIN1 BAG3 BRD7 BUB1 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FBXW7 FRAT1 FZD7 GNAI3 HDHD2 HECW1 LRRK2 MLH3 MSH2 NCK2 NEDD4 PPM1A PSMA3 RAC1 RB1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SMYD1 SNCA TRIM69 USP13 VANGL1 VANGL2	7 interacting genes: AMBP B3GALT4 DVL1 DVL2 PRPF40A RHOA USP10
Entrez ID		1855	23002
HPRD ID		03220	09433
Ensembl ID		ENSG00000107404	ENSG00000100592
Uniprot IDs		O14640	Q9Y4D1
PDB IDs		6LCA 6LCB 6TTK	2J1D 2Z6E
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway I-SMAD Binding Regulation Of Canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Signal Transduction Heteromeric SMAD Protein Complex Regulation Of Protein Catabolic Process Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process SMAD Protein Complex Cytoplasm Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Response To Growth Factor R-SMAD Binding Positive Regulation Of Protein Metabolic Process Embryonic Pattern Specification Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Stability Cellular Response To Growth Factor Stimulus Dorsal/ventral Axis Specification Regulation Of Cellular Component Organization Cytosol Negative Regulation Of Biosynthetic Process	Wnt Signaling Pathway, Planar Cell Polarity Pathway Convergent Extension Involved In Neural Plate Elongation Non-canonical Wnt Signaling Pathway Convergent Extension Involved In Organogenesis Convergent Extension Involved In Gastrulation Positive Regulation Of Neuron Projection Arborization Epithelial Tube Morphogenesis Convergent Extension Regulation Of Neuron Projection Arborization Cochlea Morphogenesis Frizzled Binding Regulation Of Cell Morphogenesis Wnt Signaling Pathway Cytochrome C Metabolic Process Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cytoplasmic Microtubule Organization Tube Morphogenesis Mitotic Cleavage Furrow Formation Morphogenesis Of An Epithelium Outflow Tract Morphogenesis Lateral Plasma Membrane Heart Looping Embryonic Heart Tube Morphogenesis Ganglioside Galactosyltransferase Activity Clathrin-coated Vesicle Calcium Oxalate Binding Aortic Valve Formation Protein Kinase Binding Positive Regulation Of Vascular Associated Smooth Muscle Contraction Tissue Morphogenesis Endothelial Tube Lumen Extension Skeletal Muscle Satellite Cell Migration Regulation Of Cytokinesis Positive Regulation Of Protein Localization To Presynapse Canonical Wnt Signaling Pathway Negative Regulation Of Stress Granule Assembly Collagen Fibril Binding IgA Binding Beta Selection Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor Cytochrome Metabolic Process Bone Trabecula Morphogenesis Regulation Of JNK Cascade Dendritic Spine Apolipoprotein A-I-mediated Signaling Pathway Roundabout Signaling Pathway Matrix Side Of Mitochondrial Inner Membrane Organelle Organization Regulation Of Cell Division Regulation Of Systemic Arterial Blood Pressure By Endothelin
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?