DVL1 and HECW1

Number of citations of the paper that reports this interaction (PubMedID 14684739)
0

Data Source:
HPRD (in vivo, two hybrid)

		DVL1	HECW1
Description		dishevelled segment polarity protein 1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse Neuronal Dense Core Vesicle Wnt Signalosome	Cytoplasm Cytosol
	Molecular Function	Frizzled Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Small GTPase Binding Identical Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Heart Looping Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Neurotransmitter Secretion Axonogenesis Axon Guidance Neuromuscular Junction Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Synaptic Vesicle Exocytosis Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Cytoplasmic Microtubule Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Receptor Clustering Positive Regulation Of Transcription By RNA Polymerase II Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Protein Stabilization Convergent Extension Involved In Organogenesis Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Dendritic Spine Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Cochlea Morphogenesis Presynapse Assembly Postsynapse Organization Regulation Of Postsynapse Organization Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Protein Localization To Presynapse Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Dendrite Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	Degradation of DVL
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 28067908) Nicotine dependence ( 32281736) Ulcerative colitis ( 28067908)	Alzheimer's disease (cognitive decline) ( 23535033) Bone mineral density (Ward's triangle area) ( 27397699) Caudal anterior-cingulate cortex volume ( 31530798) Cerebrospinal fluid AB1-42 levels ( 26252872) Delirium ( 29631748) Diverticular disease ( 28585551) Irritable bowel syndrome ( 29673008) Lung cancer in ever smokers ( 28604730) Mercury levels ( 26025379) Obesity-related traits ( 23251661) Serum galactose-deficient IgA1 levels ( 28187132) Type 2 diabetes ( 25102180)
Interacting Genes		45 interacting genes: ANXA7 ARRB1 ATN1 AXIN1 BAG3 BRD7 BUB1 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FBXW7 FRAT1 FZD7 GNAI3 HDHD2 HECW1 LRRK2 MLH3 MSH2 NCK2 NEDD4 PPM1A PSMA3 RAC1 RB1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SMYD1 SNCA TRIM69 USP13 VANGL1 VANGL2	19 interacting genes: CACNA1A DVL1 GFI1B PRRG4 SCNN1A SCNN1B SHANK3 SSR4 TNK2 TP53 TSC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2J2 UBE2L3 USP7 VAX1
Entrez ID		1855	23072
HPRD ID		03220	11385
Ensembl ID		ENSG00000107404	ENSG00000002746
Uniprot IDs		O14640	Q76N89
PDB IDs		6LCA 6LCB 6TTK	3L4H
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway I-SMAD Binding Regulation Of Canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Signal Transduction Heteromeric SMAD Protein Complex Regulation Of Protein Catabolic Process Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process SMAD Protein Complex Cytoplasm Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Response To Growth Factor R-SMAD Binding Positive Regulation Of Protein Metabolic Process Embryonic Pattern Specification Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Stability Cellular Response To Growth Factor Stimulus Dorsal/ventral Axis Specification Regulation Of Cellular Component Organization Cytosol Negative Regulation Of Biosynthetic Process	Ubiquitin Conjugating Enzyme Activity WW Domain Binding Protein Ubiquitination Sensory Perception Of Salty Taste Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Polyubiquitination Cellular Response To Aldosterone Sodium Channel Complex Ubiquitin Protein Ligase Binding Post-translational Protein Modification Proteolysis Modification-dependent Protein Catabolic Process Regulation Of Protein Targeting To Mitochondrion Sensory Perception Of Sour Taste Cellular Response To Vasopressin TORC1 Signaling Cellular Response To Corticosteroid Stimulus Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Negative Regulation Of ATP-dependent Activity Negative Regulation Of Neuroblast Proliferation Cellular Response To Steroid Hormone Stimulus TOR Signaling Protein Stabilization Negative Regulation Of TOR Signaling Inorganic Cation Import Across Plasma Membrane Response To Nutrient Levels Ubiquitin-protein Transferase Activity Response To Aldosterone Cellular Response To Nutrient Levels Regulation Of TORC1 Signaling Dendritic Spine Morphogenesis Cellular Response To Acidic PH Negative Regulation Of Autophagy Protein K48-linked Ubiquitination Intracellular Sodium Ion Homeostasis Ubiquitin-dependent Protein Catabolic Process Sodium Ion Import Across Plasma Membrane Response To Acidic PH Protein K6-linked Ubiquitination Cellular Response To PH Negative Regulation Of Neural Precursor Cell Proliferation Multicellular Organismal-level Water Homeostasis Import Across Plasma Membrane Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization
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